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LY 404187 - 98%, high purity , CAS No.211311-95-4, Allosteric modulator of GluA1;Allosteric modulator of GluA2;Allosteric modulator of GluA3;Allosteric modulator of GluA4

  • Moligand™
  • ≥98%
Item Number
L274875
Grouped product items
SKUSizeAvailabilityPrice Qty
L274875-1mg
1mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$23.90
L274875-5mg
5mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$98.90
L274875-10mg
10mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$167.90
L274875-50mg
50mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$756.90
L274875-100mg
100mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$1,360.90

Novel, selective AMPA receptor positive allosteric modulator

Basic Description

Synonyms211311-95-4|N-(2-(4'-Cyano-[1,1'-biphenyl]-4-yl)propyl)propane-2-sulfonamide|LY404187|LY-404187|LY 404187|N-[2-[4-(4-cyanophenyl)phenyl]propyl]propane-2-sulfonamide|75W6I8W6OU|CHEMBL435582|N-2-(4-(4-Cyanophenyl)phenyl)propyl 2-propanesulfonamide|2-Propane
Specifications & PurityMoligand™, ≥98%
Biochemical and Physiological MechanismsNovel, selective AMPA receptor positive allosteric modulator (IC 50 values\xa0of 0.15, 0.21, 1.66 and 5.65 μ M for GluA2 i , GluA4 i , GluA3 i and GluA1 i respectively).
Storage TempStore at 2-8°C
Shipped InWet ice
GradeMoligand™
Action TypeALLOSTERIC MODULATOR
Mechanism of actionAllosteric modulator of GluA1;Allosteric modulator of GluA2;Allosteric modulator of GluA3;Allosteric modulator of GluA4
NoteRefer to SDS for further information. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description

Shipped at Room Temperature. Store at +4°C.

Associated Targets

HDAC6 Tclin Histone deacetylase 6 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

GRIA4 Tclin Glutamate receptor 4 6 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

GRIA2 Tclin Glutamate receptor 2 5 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

GRIA3 Tclin Glutamate receptor 3 2 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

GRIA1 Tclin Glutamate receptor 1 2 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

Names and Identifiers

IUPAC Name N-[2-[4-(4-cyanophenyl)phenyl]propyl]propane-2-sulfonamide
INCHI InChI=1S/C19H22N2O2S/c1-14(2)24(22,23)21-13-15(3)17-8-10-19(11-9-17)18-6-4-16(12-20)5-7-18/h4-11,14-15,21H,13H2,1-3H3
InChi Key HOQAVGZLYRYHSO-UHFFFAOYSA-N
Canonical SMILES CC(C)S(=O)(=O)NCC(C)C1=CC=C(C=C1)C2=CC=C(C=C2)C#N
Isomeric SMILES CC(C)S(=O)(=O)NCC(C)C1=CC=C(C=C1)C2=CC=C(C=C2)C#N
PubChem CID 9928016
Molecular Weight 342.46

Certificates

Certificate of Analysis(COA)

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Chemical and Physical Properties

SolubilitySoluble in DMSO to 100mM and in\xa0ethanol to 50mM

Related Documents

Solution Calculators