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Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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L274875-1mg | 1mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $23.90 | |
L274875-5mg | 5mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $98.90 | |
L274875-10mg | 10mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $167.90 | |
L274875-50mg | 50mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $756.90 | |
L274875-100mg | 100mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $1,360.90 |
Novel, selective AMPA receptor positive allosteric modulator
Synonyms | 211311-95-4|N-(2-(4'-Cyano-[1,1'-biphenyl]-4-yl)propyl)propane-2-sulfonamide|LY404187|LY-404187|LY 404187|N-[2-[4-(4-cyanophenyl)phenyl]propyl]propane-2-sulfonamide|75W6I8W6OU|CHEMBL435582|N-2-(4-(4-Cyanophenyl)phenyl)propyl 2-propanesulfonamide|2-Propane |
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Specifications & Purity | Moligand™, ≥98% |
Biochemical and Physiological Mechanisms | Novel, selective AMPA receptor positive allosteric modulator (IC 50 values\xa0of 0.15, 0.21, 1.66 and 5.65 μ M for GluA2 i , GluA4 i , GluA3 i and GluA1 i respectively). |
Storage Temp | Store at 2-8°C |
Shipped In | Wet ice |
Grade | Moligand™ |
Action Type | ALLOSTERIC MODULATOR |
Mechanism of action | Allosteric modulator of GluA1;Allosteric modulator of GluA2;Allosteric modulator of GluA3;Allosteric modulator of GluA4 |
Note | Refer to SDS for further information. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details. |
Product Description | Shipped at Room Temperature. Store at +4°C. |
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IUPAC Name | N-[2-[4-(4-cyanophenyl)phenyl]propyl]propane-2-sulfonamide |
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INCHI | InChI=1S/C19H22N2O2S/c1-14(2)24(22,23)21-13-15(3)17-8-10-19(11-9-17)18-6-4-16(12-20)5-7-18/h4-11,14-15,21H,13H2,1-3H3 |
InChi Key | HOQAVGZLYRYHSO-UHFFFAOYSA-N |
Canonical SMILES | CC(C)S(=O)(=O)NCC(C)C1=CC=C(C=C1)C2=CC=C(C=C2)C#N |
Isomeric SMILES | CC(C)S(=O)(=O)NCC(C)C1=CC=C(C=C1)C2=CC=C(C=C2)C#N |
PubChem CID | 9928016 |
Molecular Weight | 342.46 |
PubChem CID | 9928016 |
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CAS Registry No. | 211311-95-4 |
ChEMBL Ligand | CHEMBL435582 |
Wikipedia | LY-404,187 |
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Solubility | Soluble in DMSO to 100mM and in\xa0ethanol to 50mM |
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