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LY 456236 hydrochloride - 98%, high purity , CAS No.338736-46-2

≥98%

CAS#: 338736-46-2
Formula: C₁₆H₁₆ClN₃O₂
Molecular Weight: 317.77
PubChem CID: 9926998

Item Number

L274794

Grouped product items
SKU	Size	Availability	Price
L274794-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$110.90
L274794-10mg	10mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$176.90
L274794-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$411.90
L274794-50mg	50mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$699.90
L274794-100mg	100mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,119.90

mGlu 1 non competitive antagonist

View related series

GPCR/G Protein JAK/STAT Signaling mGluR EGFR Protein Tyrosine Kinase/RTK

Basic Description

Synonyms	LY 456236 HYDROCHLORIDE\|338738-57-1\|338736-46-2\|MPMQ hydrochloride\|MPMQ\|LY456236 Hydrochloride\|6-methoxy-N-(4-methoxyphenyl)quinazolin-4-amine Hydrochloride\|EU75F68HWQ\|LY456236 HCl\|LY456236\|LY 456236\|LY-456236\|UNII-EU75F68HWQ\|6-methoxy-N-(4-methoxyphenyl)
Specifications & Purity	98%
Storage Temp	Store at 2-8°C,Desiccated
Shipped In	Wet ice
Product Description	Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months. LY 456236 hydrochloride is an mGlu1 receptor antagonist with an ic50 value of 143 nM. LY456236 has selective, non-competitive and oral activity, and can inhibit the hydrolysis of inositol phosphate with IC50 of 0.145 μM. LY 456236 hydrochloride inhibited EGFR with IC50 of 0.91 μM.

Names and Identifiers

IUPAC Name	6-methoxy-N-(4-methoxyphenyl)quinazolin-4-amine;hydrochloride
INCHI	InChI=1S/C16H15N3O2.ClH/c1-20-12-5-3-11(4-6-12)19-16-14-9-13(21-2)7-8-15(14)17-10-18-16;/h3-10H,1-2H3,(H,17,18,19);1H
InChi Key	AVKFOWUSTVWZQN-UHFFFAOYSA-N
Canonical SMILES	COC1=CC=C(C=C1)NC2=NC=NC3=C2C=C(C=C3)OC.Cl
Isomeric SMILES	COC1=CC=C(C=C1)NC2=NC=NC3=C2C=C(C=C3)OC.Cl
PubChem CID	9926998
Molecular Weight	317.77

Certificates

Certificate of Analysis(COA)

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10 results found

Lot Number	Certificate Type	Date	Item
B2428450	Certificate of Analysis	Jan 22, 2024	L274794
B2428452	Certificate of Analysis	Jan 22, 2024	L274794
B2428453	Certificate of Analysis	Jan 22, 2024	L274794
B2428454	Certificate of Analysis	Jan 22, 2024	L274794
B2428457	Certificate of Analysis	Jan 22, 2024	L274794
B2428459	Certificate of Analysis	Jan 22, 2024	L274794
B2428461	Certificate of Analysis	Jan 22, 2024	L274794
B2428462	Certificate of Analysis	Jan 22, 2024	L274794
B2428463	Certificate of Analysis	Jan 22, 2024	L274794
B2428464	Certificate of Analysis	Jan 22, 2024	L274794

Solubility

Soluble in DMSO to 50 mM (with warming)

Sensitivity

Moisture sensitive

Safety and Hazards(GHS)

Pictogram(s)	GHS05, GHS07
Signal	Danger
Hazard Statements	H315:Causes skin irritation H335:May cause respiratory irritation H413:May cause long lasting harmful effects to aquatic life H302:Harmful if swallowed H318:Causes serious eye damage
Precautionary Statements	P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P273:Avoid release to the environment. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P271:Use only outdoors or in a well-ventilated area. P270:Do not eat, drink or smoke when using this product. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P362+P364:Take off contaminated clothing and wash it before reuse. P330:Rinse mouth. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P301+P317:IF SWALLOWED: Get medical help. P305+P354+P338:IF IN EYES: Immediately rinse with water for several minutes. Remove contact lenses if present and easy to do. Continue rinsing. P317:Get emergency medical help. P332+P317:If skin irritation occurs: Get medical help. P319:Get medical help if you feel unwell.

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