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LY2033298 - 95%, high purity , CAS No.886047-13-8, Allosteric modulator of M 2 receptor;Allosteric modulator of M 4 receptor

Moligand™
≥95%

CAS#: 886047-13-8
Formula: C₁₃H₁₄ClN₃O₂S
Molecular Weight: 311.79
PubChem CID: 11536903

Item Number

A195580

Grouped product items
SKU	Size	Availability	Price
A195580-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$185.90
A195580-10mg	10mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$333.90
A195580-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,176.90

Selective positive allosteric modulator of M4receptors; activein vivo; antipsychotic

View related series

M2 receptor Allosteric modulator M4 receptor Allosteric modulator

Basic Description

Synonyms	886047-13-8\|3-Amino-5-chloro-N-cyclopropyl-6-methoxy-4-methylthieno[2,3-b]pyridine-2-carboxamide\|LY2033298\|LY 2033298\|LY-2033298\|5YG6JK4ECM\|CHEMBL3770346\|3-Amino-5-chloro-N-cyclopropyl-6-methoxy-4-methyl-thieno[2,3-b]pyridine-2-carboxamide\|LY2033298;LY-20
Specifications & Purity	95%
Storage Temp	Store at -20°C,Argon charged
Shipped In	Ice chest + Ice pads
Grade	Moligand™
Action Type	ALLOSTERIC MODULATOR
Mechanism of action	Allosteric modulator of M 2 receptor;Allosteric modulator of M 4 receptor
Product Description	Product description LY2033298 is a robust allosteric potentiator with highly selective for the human M4 muscarinic acetylcholine receptor subtype. LY2033298 enhances inhibition by oxotremorine of light-induced phase shifts in hamster circadian activity rhythms.

Associated Targets

CHRM4 Tclin Muscarinic acetylcholine receptor M4 0 Activities

Discover Target: CHRM4

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CHRM2 Tclin Muscarinic acetylcholine receptor M2 1 Activities

Discover Target: CHRM2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

IUPAC Name	3-amino-5-chloro-N-cyclopropyl-6-methoxy-4-methylthieno[2,3-b]pyridine-2-carboxamide
INCHI	InChI=1S/C13H14ClN3O2S/c1-5-7-9(15)10(11(18)16-6-3-4-6)20-13(7)17-12(19-2)8(5)14/h6H,3-4,15H2,1-2H3,(H,16,18)
InChi Key	CTEGQKDJTBWFHW-UHFFFAOYSA-N
Canonical SMILES	CC1=C2C(=C(SC2=NC(=C1Cl)OC)C(=O)NC3CC3)N
Isomeric SMILES	CC1=C2C(=C(SC2=NC(=C1Cl)OC)C(=O)NC3CC3)N
PubChem CID	11536903
Molecular Weight	311.79

CAS Registry No.

886047-13-8

PubChem CID

11536903

GPCRdb Ligand

LY2033298

Certificates

Certificate of Analysis(COA)

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6 results found

Lot Number	Certificate Type	Date	Item
A2412178	Certificate of Analysis	Dec 29, 2023	A195580
A2412185	Certificate of Analysis	Dec 29, 2023	A195580
A2412186	Certificate of Analysis	Dec 29, 2023	A195580
A2412189	Certificate of Analysis	Dec 29, 2023	A195580
A2412192	Certificate of Analysis	Dec 29, 2023	A195580
A2412196	Certificate of Analysis	Dec 29, 2023	A195580

Solubility

Solvent:DMSO, Max Conc. mg/mL: 31.18, Max Conc. mM: 100; Solvent:ethanol, Max Conc. mg/mL: 6.24, Max Conc. mM: 20

Sensitivity

Moisture sensitive

Safety and Hazards(GHS)

Pictogram(s)	GHS08
Signal	Danger
Hazard Statements	H334:May cause allergy or asthma symptoms or breathing difficulties if inhaled
Precautionary Statements	P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P501:Dispose of contents/container to ... P284:[In case of inadequate ventilation] Wear respiratory protection. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P342+P316:If experiencing respiratory symptoms: Get emergence medical help immediately.

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