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LY223982 - ≥98%, high purity , CAS No.117423-74-2, Antagonist of BLT 1 receptor

Moligand™
≥98%

CAS#: 117423-74-2
Formula: C₃₀H₃₀O₇
Molecular Weight: 502.56
PubChem CID: 6444688

Item Number

L340879

Grouped product items
SKU	Size	Availability	Price
L340879-1mg	1mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$28.90
L340879-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$117.90
L340879-10mg	10mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$188.90
L340879-50mg	50mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$659.90

a potent P2Y7 (BLT1) receptor antagonist

View related series

BLT1 receptor Antagonist

Basic Description

Synonyms	LY223982\|117423-74-2\|LY-223982\|Cgs 23131\|LY 223982\|Skf 107324\|5-(3-Carboxybenzoyl)-2-((6-(4-methoxyphenyl)-5-hexenyl)oxy)benzenepropanoic acid\|CHEMBL49302\|XG52JC545T\|Benzenepropanoic acid, 5-(3-carboxybenzoyl)-2-[[(5E)-6-(4-methoxyphenyl)-5-hexen-1-yl]oxy
Specifications & Purity	Moligand™, ≥98%
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Grade	Moligand™
Action Type	ANTAGONIST
Mechanism of action	Antagonist of BLT 1 receptor
Product Description	LY223982 is a potent and specific inhibitor of leukotriene B4 receptor, with an IC50 of 13.2 nM against [3H]LTB4 binding to LTB4 receptor.

pKa

pKa: 3.81 (Predicted)

Ki Data

P2Y7: Ki= 7.8 nM (human); Leukotriene B4 receptor: Ki= 11 nM (human)

Associated Targets

CX3CR1 Tchem CX3C chemokine receptor 1 0 Activities

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GPR35 Tchem G-protein coupled receptor 35 0 Activities

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BRD4 Tchem Bromodomain-containing protein 4 0 Activities

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CDK2 Tchem Cyclin-dependent kinase 2 0 Activities

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FFAR4 Tchem Free fatty acid receptor 4 0 Activities

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FPR2 Tchem N-formyl peptide receptor 2 0 Activities

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FGFR3 Tclin Fibroblast growth factor receptor 3 0 Activities

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CSNK1D Tchem Casein kinase I isoform delta 0 Activities

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S1PR1 Tclin Sphingosine 1-phosphate receptor 1 0 Activities

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TRIM24 Tchem Transcription intermediary factor 1-alpha 0 Activities

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LTB4R Tchem Leukotriene B4 receptor 1 1 Activities

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LTB4R2 Tchem Leukotriene B4 receptor 2 0 Activities

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C5AR1 Tclin C5a anaphylatoxin chemotactic receptor 1 0 Activities

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BRPF1 Tchem Peregrin 0 Activities

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AURKA Tchem Aurora kinase A 0 Activities

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ADRB2 Tclin Beta-2 adrenergic receptor 0 Activities

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APLNR Tchem Apelin receptor 0 Activities

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ABL1 Tclin Tyrosine-protein kinase ABL1 0 Activities

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ADRA2A Tclin Alpha-2A adrenergic receptor 0 Activities

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ADGRF1 Tbio Adhesion G-protein coupled receptor F1 0 Activities

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AGTR1 Tclin Type-1 angiotensin II receptor 0 Activities

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GSK3B Tclin Glycogen synthase kinase-3 beta 0 Activities

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GPR119 Tclin Glucose-dependent insulinotropic receptor 0 Activities

Discover Target: GPR119

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GLP1R Tclin Glucagon-like peptide 1 receptor 0 Activities

Discover Target: GLP1R

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MAPK1 Tchem Mitogen-activated protein kinase 1 0 Activities

Discover Target: MAPK1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

IUPAC Name	3-[3-(2-carboxyethyl)-4-[(E)-6-(4-methoxyphenyl)hex-5-enoxy]benzoyl]benzoic acid
INCHI	InChI=1S/C30H30O7/c1-36-26-14-10-21(11-15-26)7-4-2-3-5-18-37-27-16-12-24(19-22(27)13-17-28(31)32)29(33)23-8-6-9-25(20-23)30(34)35/h4,6-12,14-16,19-20H,2-3,5,13,17-18H2,1H3,(H,31,32)(H,34,35)/b7-4+
InChi Key	SYZSSLLFRVDRHL-QPJJXVBHSA-N
Canonical SMILES	COC1=CC=C(C=C1)C=CCCCCOC2=C(C=C(C=C2)C(=O)C3=CC(=CC=C3)C(=O)O)CCC(=O)O
Isomeric SMILES	COC1=CC=C(C=C1)/C=C/CCCCOC2=C(C=C(C=C2)C(=O)C3=CC(=CC=C3)C(=O)O)CCC(=O)O
Alternate CAS	117423-74-2
PubChem CID	6444688
MeSH Entry Terms	5-(3-carboxybenzoyl)-2-((6-(4-methoxyphenyl)-5-hexenyl)oxy)benzenepropanoic acid;CGS 23131;LY 223982;LY 233978 disodium salt;LY-223982;SK and F 107324;SK and F-107324;SKF 107324
Molecular Weight	502.56

Certificates

Certificate of Analysis(COA)

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8 results found

Lot Number	Certificate Type	Date	Item
G2419192	Certificate of Analysis	Apr 11, 2024	L340879
G2419249	Certificate of Analysis	Apr 11, 2024	L340879
G2419250	Certificate of Analysis	Apr 11, 2024	L340879
G2419251	Certificate of Analysis	Apr 11, 2024	L340879
G2419252	Certificate of Analysis	Apr 11, 2024	L340879
G2419253	Certificate of Analysis	Apr 11, 2024	L340879
G2419254	Certificate of Analysis	Apr 11, 2024	L340879
G2419255	Certificate of Analysis	Apr 11, 2024	L340879

Solubility

Soluble in 1:1 DMF:PBS (pH 7.2) (0.5 mg/ml), ethanol (0.1 mg/ml), DMF (20 mg/ml), and DMSO (~20 mg/ml).

Refractive Index

n20D1.61 (Predicted)

Boil Point(°C)

~753.8° C at 760 mmHg (Predicted)

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