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Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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L412363-1mg | 1mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $161.90 | |
L412363-5mg | 5mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $344.90 | |
L412363-10mg | 10mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $546.90 | |
L412363-25mg | 25mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $885.90 | |
L412363-50mg | 50mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $1,189.90 |
FXR Agonists
Synonyms | 1103500-20-4|LY2562175|LY-2562175|TERN-101|VVA2ZDV3LX|1H-Indole-3-carboxylic acid, 6-[4-[[5-cyclopropyl-3-(2,6-dichlorophenyl)-4-isoxazolyl]methoxy]-1-piperidinyl]-1-methyl-|6-(4-((5-cyclopropyl-3-(2,6-dichlorophenyl)isoxazol-4-yl)methoxy)piperidin-1-yl)- |
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Specifications & Purity | ≥99% |
Biochemical and Physiological Mechanisms | LY2562175 is a potent and selective agonist of FXR. LY2562175 promotes transcriptional activation of human FXR in a cell-based cotransfection assay with EC50 of 193 nM. |
Storage Temp | Store at -20°C |
Shipped In | Ice chest + Ice pads |
Action Type | AGONIST |
Mechanism of action | Bile acid receptor FXR agonist |
Product Description | LY2562175 is a potent and selective FXR agonist, with an EC50 of 193 nM. Targets human FXR (cell-based cotransfection assay) 193 nM(EC50) |
ALogP | 5.5 |
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IUPAC Name | 6-[4-[[5-cyclopropyl-3-(2,6-dichlorophenyl)-1,2-oxazol-4-yl]methoxy]piperidin-1-yl]-1-methylindole-3-carboxylic acid |
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INCHI | InChI=1S/C28H27Cl2N3O4/c1-32-14-20(28(34)35)19-8-7-17(13-24(19)32)33-11-9-18(10-12-33)36-15-21-26(31-37-27(21)16-5-6-16)25-22(29)3-2-4-23(25)30/h2-4,7-8,13-14,16,18H,5-6,9-12,15H2,1H3,(H,34,35) |
InChi Key | RPVDFHPBGBMWID-UHFFFAOYSA-N |
Canonical SMILES | CN1C=C(C2=C1C=C(C=C2)N3CCC(CC3)OCC4=C(ON=C4C5=C(C=CC=C5Cl)Cl)C6CC6)C(=O)O |
Isomeric SMILES | CN1C=C(C2=C1C=C(C=C2)N3CCC(CC3)OCC4=C(ON=C4C5=C(C=CC=C5Cl)Cl)C6CC6)C(=O)O |
PubChem CID | 25204767 |
Molecular Weight | 540.44 |
Enter Lot Number to search for COA:
To view the certificate results,please click on a Lot number.For Lot numbers from past orders,please use our order status section
Lot Number | Certificate Type | Date | Item |
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G2411237 | Certificate of Analysis | Mar 15, 2024 | L412363 |
G2411268 | Certificate of Analysis | Mar 15, 2024 | L412363 |
G2411269 | Certificate of Analysis | Mar 15, 2024 | L412363 |
G2411270 | Certificate of Analysis | Mar 15, 2024 | L412363 |
G2411271 | Certificate of Analysis | Mar 15, 2024 | L412363 |
G2411272 | Certificate of Analysis | Mar 15, 2024 | L412363 |
G2411273 | Certificate of Analysis | Mar 15, 2024 | L412363 |
G2411274 | Certificate of Analysis | Mar 15, 2024 | L412363 |
G2411275 | Certificate of Analysis | Mar 15, 2024 | L412363 |
G2411276 | Certificate of Analysis | Mar 15, 2024 | L412363 |
Solubility | Solubility (25°C) In vitro DMSO: 100 mg/mL (185.03 mM); Ethanol: 1.5 mg/mL (2.77 mM); Water: Insoluble; |
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