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LY2928057 (anti-SLC40A1) (Ab175589) - SEC
The purity of LY2928057 (anti-SLC40A1) (Ab175589) is more than 95% verified by HPLC.
Purity>95% (SDS-PAGE&SEC); Endotoxin Level<1.0EU/mg; Human IgG4SP; CHO; ELISA, FACS, Functional assay, Animal Model; Unconjugated
SKU | Size | Availability | Price | Qty |
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Ab175589-100μg | 100μg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $109.90 | |
Ab175589-1mg | 1mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $519.90 | |
Ab175589-5mg | 5mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $1,399.90 | |
Ab175589-10mg | 10mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $2,239.90 |
Purity>95% (SDS-PAGE&SEC); Endotoxin Level<1.0EU/mg; Human IgG4SP; CHO; ELISA, FACS, Functional assay, Animal Model; Unconjugated
Product Name | LY2928057 (anti-SLC40A1) - Primary antibody, specific to SLC40A1, >95%, high purity, Human IgG4SP |
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Synonyms | Ferroportin 1 antibody; Ferroportin antibody; Ferroportin-1 antibody; FPN1 antibody; HFE4 antibody; IREG1 antibody; iron regulated gene 1 antibody; Iron regulated transporter 1 antibody; Iron-regulated transporter 1 antibody; MST079 antibody; MSTP079 anti |
Specifications & Purity | ExactAb™, Validated, Carrier Free, Low Endotoxin, Azide Free, Recombinant, ≥95%(SDS-PAGE&SEC), Lot by Lot |
Specificity | SLC40A1 |
Conjugation | Unconjugated |
Grade | Azide Free, Carrier Free, ExactAb™, Low Endotoxin, Recombinant, Validated |
Action Type | ANTIBODY |
Mechanism of action | Antibody of Ferroportin |
Product Description | LY2928057 (anti-SLC40A1) is a monoclonal antibody targeting SLC40A1. It has the potential to do research on mineral absorption, insulin receptor recycling, and transmembrane transporter activity. |
Isotype | Human IgG4SP |
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Light Chain Type | kappa |
SDS-PAGE | 26.7 kDa (Light Chain) & 51.9 kDa (Heavy Chain), under reducing conditions; 186.1 kDa, under non-reducing conditions. |
Purification Method | Protein A purified |
Purity | >95% |
Form | Liquid |
Concentration | Lot by Lot |
Storage Temp | Store at -80°C,Avoid repeated freezing and thawing |
Shipped In | Ice chest + Ice pads |
Stability And Storage | Store at -80℃ for 24 months. Upon delivery aliquot. Avoid freeze/thaw cycle. |
LY2928057 (anti-SLC40A1) (Ab175589) - SEC
The purity of LY2928057 (anti-SLC40A1) (Ab175589) is more than 95% verified by HPLC.
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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Enter Lot Number to search for COA:
To view the certificate results,please click on a Lot number.For Lot numbers from past orders,please use our order status section
Lot Number | Certificate Type | Date | Item |
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ZJ24F0404908 | Certificate of Analysis | Apr 25, 2024 | Ab175589 |
ZJ24F0404907 | Certificate of Analysis | Apr 25, 2024 | Ab175589 |
ZJ24F0404906 | Certificate of Analysis | Apr 25, 2024 | Ab175589 |
1. Fung E, Chua K, Ganz T, Nemeth E, Ruchala P.. (2015) Thiol-derivatized minihepcidins retain biological activity.. Bioorg Med Chem Lett, 25 (4): (763-766). [PMID:25599838] |
2. Chua K, Fung E, Micewicz ED, Ganz T, Nemeth E, Ruchala P.. (2015) Small cyclic agonists of iron regulatory hormone hepcidin.. Bioorg Med Chem Lett, 25 (21): (4961-4969). [PMID:25813158] |
3. Donovan, A A and 19 more authors.. (2000) Positional cloning of zebrafish ferroportin1 identifies a conserved vertebrate iron exporter.. Nature, (17): [PMID:10693807] |
4. Abboud, S S and Haile, D J DJ.. (2000) A novel mammalian iron-regulated protein involved in intracellular iron metabolism.. The Journal of biological chemistry, (30): [PMID:10747949] |
5. McKie, A T AT and 12 more authors.. (2000) A novel duodenal iron-regulated transporter, IREG1, implicated in the basolateral transfer of iron to the circulation.. Molecular cell, [PMID:10882071] |
6. Wiemann, S S and 23 more authors.. (2001) Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.. Genome research, [PMID:11230166] |
7. Njajou, O T OT and 11 more authors.. (2001) A mutation in SLC11A3 is associated with autosomal dominant hemochromatosis.. Nature genetics, [PMID:11431687] |
8. Montosi, G G and 9 more authors.. (2001) Autosomal-dominant hemochromatosis is associated with a mutation in the ferroportin (SLC11A3) gene.. The Journal of clinical investigation, [PMID:11518736] |
9. Wallace, Daniel F DF and 6 more authors.. (2002) Novel mutation in ferroportin1 is associated with autosomal dominant hemochromatosis.. Blood, (15): [PMID:12091366] |
10. Devalia, Vinod V and 6 more authors.. (2002) Autosomal dominant reticuloendothelial iron overload associated with a 3-base pair deletion in the ferroportin 1 gene (SLC11A3).. Blood, (15): [PMID:12091367] |
11. Roetto, Antonella A and 9 more authors.. (2002) A valine deletion of ferroportin 1: a common mutation in hemochromastosis type 4.. Blood, (15): [PMID:12123233] |
12. Cazzola, Mario M and 11 more authors.. (2002) Genetic hyperferritinaemia and reticuloendothelial iron overload associated with a three base pair deletion in the coding region of the ferroportin gene (SLC11A3).. British journal of haematology, [PMID:12406098] |
13. Hetet, Gilles G, Devaux, Isabelle I, Soufir, Nadem N, Grandchamp, Bernard B and Beaumont, Carole C.. (2003) Molecular analyses of patients with hyperferritinemia and normal serum iron values reveal both L ferritin IRE and 3 new ferroportin (slc11A3) mutations.. Blood, (1): [PMID:12730114] |
14. Rivard, Sylvain R SR and 9 more authors.. (2003) Autosomal dominant reticuloendothelial iron overload (HFE type 4) due to a new missense mutation in the FERROPORTIN 1 gene (SLC11A3) in a large French-Canadian family.. Haematologica, [PMID:12857562] |
15. Arden, K E KE and 8 more authors.. (2003) A novel mutation in ferroportin1 is associated with haemochromatosis in a Solomon Islands patient.. Gut, [PMID:12865285] |
16. Jouanolle, Anne-Marie AM and 12 more authors.. (2003) Novel mutation in ferroportin 1 gene is associated with autosomal dominant iron overload.. Journal of hepatology, [PMID:12873829] |
17. Gordeuk, Victor R VR and 16 more authors.. () Iron overload in Africans and African-Americans and a common mutation in the SCL40A1 (ferroportin 1) gene.. Blood cells, molecules & diseases, [PMID:14636642] |
18. and Pietrangelo, Antonello A.. () The ferroportin disease.. Blood cells, molecules & diseases, [PMID:14757427] |
19. Zaahl, Monique G MG and 5 more authors.. (2004) Analysis of genes implicated in iron regulation in individuals presenting with primary iron overload.. Human genetics, [PMID:15338274] |
20. Robson, K J H KJ and 7 more authors.. (2004) Recent advances in understanding haemochromatosis: a transition state.. Journal of medical genetics, [PMID:15466004] |
21. Schimanski, Lisa M LM and 10 more authors.. (2005) In vitro functional analysis of human ferroportin (FPN) and hemochromatosis-associated FPN mutations.. Blood, (15): [PMID:15692071] |
22. Cremonesi, L L and 12 more authors.. (2005) Genetic and clinical heterogeneity of ferroportin disease.. British journal of haematology, [PMID:16351644] |
23. Madejczyk, Michael S MS and Ballatori, Nazzareno N.. (2012) The iron transporter ferroportin can also function as a manganese exporter.. Biochimica et biophysica acta, [PMID:22178646] |
24. Qiao, Bo B and 6 more authors.. (2012) Hepcidin-induced endocytosis of ferroportin is dependent on ferroportin ubiquitination.. Cell metabolism, (6): [PMID:22682227] |
25. Rungaldier, Stefanie S, Oberwagner, Walter W, Salzer, Ulrich U, Csaszar, Edina E and Prohaska, Rainer R.. (2013) Stomatin interacts with GLUT1/SLC2A1, band 3/SLC4A1, and aquaporin-1 in human erythrocyte membrane domains.. Biochimica et biophysica acta, [PMID:23219802] |
26. Mitchell, Colin J CJ, Shawki, Ali A, Ganz, Tomas T, Nemeth, Elizabeta E and Mackenzie, Bryan B.. (2014) Functional properties of human ferroportin, a cellular iron exporter reactive also with cobalt and zinc.. American journal of physiology. Cell physiology, (1): [PMID:24304836] |
27. Aschemeyer, Sharraya S and 13 more authors.. (2018) Structure-function analysis of ferroportin defines the binding site and an alternative mechanism of action of hepcidin.. Blood, (22): [PMID:29237594] |
28. Zhang, De-Liang DL and 11 more authors.. (2018) Erythrocytic ferroportin reduces intracellular iron accumulation, hemolysis, and malaria risk.. Science (New York, N.Y.), (30): [PMID:29599243] |
29. Choi, Eun-Kyung EK, Nguyen, Trang-Tiffany TT, Iwase, Shigeki S and Seo, Young Ah YA.. (2019) Ferroportin disease mutations influence manganese accumulation and cytotoxicity.. FASEB journal : official publication of the Federation of American Societies for Experimental Biology, [PMID:30247984] |
30. Billesbølle, Christian B and 9 more authors.. (2020) Structure of hepcidin-bound ferroportin reveals iron homeostatic mechanisms.. Nature, [PMID:32814342] |