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LY2928057 (anti-SLC40A1) - Primary antibody, specific to SLC40A1, >95%, high purity, Human IgG4SP, Antibody of Ferroportin

  • Azide Free
  • Carrier Free
  • ExactAb™
  • Low Endotoxin
  • Recombinant
  • Validated
  • ≥95%(SDS-PAGE&SEC)
  • Lot by Lot
Features and benefits
  • Short Overview:

    Purity>95% (SDS-PAGE&SEC); Endotoxin Level<1.0EU/mg; Human IgG4SP; CHO; ELISA, FACS, Functional assay, Animal Model; Unconjugated

  • Species reactivity(Reacts with): Cynomolgus monkey,Human,Rat
  • Isotype: Human IgG4SP
    Application:
  • Animal Model
  • ELISA
  • Flow Cytometry
  • Functional Assay
Item Number
Ab175589
Grouped product items
SKUSizeAvailabilityPrice Qty
Ab175589-100μg
100μg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$109.90
Ab175589-1mg
1mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$519.90
Ab175589-5mg
5mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$1,399.90
Ab175589-10mg
10mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$2,239.90

Purity>95% (SDS-PAGE&SEC); Endotoxin Level<1.0EU/mg; Human IgG4SP; CHO; ELISA, FACS, Functional assay, Animal Model; Unconjugated

Basic Description

Product NameLY2928057 (anti-SLC40A1) - Primary antibody, specific to SLC40A1, >95%, high purity, Human IgG4SP
SynonymsFerroportin 1 antibody; Ferroportin antibody; Ferroportin-1 antibody; FPN1 antibody; HFE4 antibody; IREG1 antibody; iron regulated gene 1 antibody; Iron regulated transporter 1 antibody; Iron-regulated transporter 1 antibody; MST079 antibody; MSTP079 anti
Specifications & PurityExactAb™, Validated, Carrier Free, Low Endotoxin, Azide Free, Recombinant, ≥95%(SDS-PAGE&SEC), Lot by Lot
SpecificitySLC40A1
ConjugationUnconjugated
GradeAzide Free, Carrier Free, ExactAb™, Low Endotoxin, Recombinant, Validated
Action TypeANTIBODY
Mechanism of actionAntibody of Ferroportin
Product Description

LY2928057 (anti-SLC40A1) is a monoclonal antibody targeting SLC40A1. It has the potential to do research on mineral absorption, insulin receptor recycling, and transmembrane transporter activity.

Product Properties

IsotypeHuman IgG4SP
Light Chain Typekappa
SDS-PAGE26.7 kDa (Light Chain) & 51.9 kDa (Heavy Chain), under reducing conditions; 186.1 kDa, under non-reducing conditions.
Purification MethodProtein A purified
Purity>95%
FormLiquid
ConcentrationLot by Lot
Storage TempStore at -80°C,Avoid repeated freezing and thawing
Shipped InIce chest + Ice pads
Stability And StorageStore at -80℃ for 24 months. Upon delivery aliquot. Avoid freeze/thaw cycle.

Images

LY2928057 (anti-SLC40A1) (Ab175589) - SEC
The purity of LY2928057 (anti-SLC40A1) (Ab175589) is more than 95% verified by HPLC.

Associated Targets

SLC40A1 Tchem Solute carrier family 40 member 1 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

To view the certificate results,please click on a Lot number.For Lot numbers from past orders,please use our order status section

3 results found

Lot NumberCertificate TypeDateItem
ZJ24F0404908Certificate of AnalysisApr 25, 2024 Ab175589
ZJ24F0404907Certificate of AnalysisApr 25, 2024 Ab175589
ZJ24F0404906Certificate of AnalysisApr 25, 2024 Ab175589

Related Documents

References

1. Fung E, Chua K, Ganz T, Nemeth E, Ruchala P..  (2015)  Thiol-derivatized minihepcidins retain biological activity..  Bioorg Med Chem Lett,  25  (4): (763-766).  [PMID:25599838]
2. Chua K, Fung E, Micewicz ED, Ganz T, Nemeth E, Ruchala P..  (2015)  Small cyclic agonists of iron regulatory hormone hepcidin..  Bioorg Med Chem Lett,  25  (21): (4961-4969).  [PMID:25813158]
3. Donovan, A A and 19 more authors..  (2000)  Positional cloning of zebrafish ferroportin1 identifies a conserved vertebrate iron exporter..  Nature,    (17):   [PMID:10693807]
4. Abboud, S S and Haile, D J DJ..  (2000)  A novel mammalian iron-regulated protein involved in intracellular iron metabolism..  The Journal of biological chemistry,    (30):   [PMID:10747949]
5. McKie, A T AT and 12 more authors..  (2000)  A novel duodenal iron-regulated transporter, IREG1, implicated in the basolateral transfer of iron to the circulation..  Molecular cell,      [PMID:10882071]
6. Wiemann, S S and 23 more authors..  (2001)  Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs..  Genome research,      [PMID:11230166]
7. Njajou, O T OT and 11 more authors..  (2001)  A mutation in SLC11A3 is associated with autosomal dominant hemochromatosis..  Nature genetics,      [PMID:11431687]
8. Montosi, G G and 9 more authors..  (2001)  Autosomal-dominant hemochromatosis is associated with a mutation in the ferroportin (SLC11A3) gene..  The Journal of clinical investigation,      [PMID:11518736]
9. Wallace, Daniel F DF and 6 more authors..  (2002)  Novel mutation in ferroportin1 is associated with autosomal dominant hemochromatosis..  Blood,    (15):   [PMID:12091366]
10. Devalia, Vinod V and 6 more authors..  (2002)  Autosomal dominant reticuloendothelial iron overload associated with a 3-base pair deletion in the ferroportin 1 gene (SLC11A3)..  Blood,    (15):   [PMID:12091367]
11. Roetto, Antonella A and 9 more authors..  (2002)  A valine deletion of ferroportin 1: a common mutation in hemochromastosis type 4..  Blood,    (15):   [PMID:12123233]
12. Cazzola, Mario M and 11 more authors..  (2002)  Genetic hyperferritinaemia and reticuloendothelial iron overload associated with a three base pair deletion in the coding region of the ferroportin gene (SLC11A3)..  British journal of haematology,      [PMID:12406098]
13. Hetet, Gilles G, Devaux, Isabelle I, Soufir, Nadem N, Grandchamp, Bernard B and Beaumont, Carole C..  (2003)  Molecular analyses of patients with hyperferritinemia and normal serum iron values reveal both L ferritin IRE and 3 new ferroportin (slc11A3) mutations..  Blood,    (1):   [PMID:12730114]
14. Rivard, Sylvain R SR and 9 more authors..  (2003)  Autosomal dominant reticuloendothelial iron overload (HFE type 4) due to a new missense mutation in the FERROPORTIN 1 gene (SLC11A3) in a large French-Canadian family..  Haematologica,      [PMID:12857562]
15. Arden, K E KE and 8 more authors..  (2003)  A novel mutation in ferroportin1 is associated with haemochromatosis in a Solomon Islands patient..  Gut,      [PMID:12865285]
16. Jouanolle, Anne-Marie AM and 12 more authors..  (2003)  Novel mutation in ferroportin 1 gene is associated with autosomal dominant iron overload..  Journal of hepatology,      [PMID:12873829]
17. Gordeuk, Victor R VR and 16 more authors..  ()  Iron overload in Africans and African-Americans and a common mutation in the SCL40A1 (ferroportin 1) gene..  Blood cells, molecules & diseases,      [PMID:14636642]
18. and Pietrangelo, Antonello A..  ()  The ferroportin disease..  Blood cells, molecules & diseases,      [PMID:14757427]
19. Zaahl, Monique G MG and 5 more authors..  (2004)  Analysis of genes implicated in iron regulation in individuals presenting with primary iron overload..  Human genetics,      [PMID:15338274]
20. Robson, K J H KJ and 7 more authors..  (2004)  Recent advances in understanding haemochromatosis: a transition state..  Journal of medical genetics,      [PMID:15466004]
21. Schimanski, Lisa M LM and 10 more authors..  (2005)  In vitro functional analysis of human ferroportin (FPN) and hemochromatosis-associated FPN mutations..  Blood,    (15):   [PMID:15692071]
22. Cremonesi, L L and 12 more authors..  (2005)  Genetic and clinical heterogeneity of ferroportin disease..  British journal of haematology,      [PMID:16351644]
23. Madejczyk, Michael S MS and Ballatori, Nazzareno N..  (2012)  The iron transporter ferroportin can also function as a manganese exporter..  Biochimica et biophysica acta,      [PMID:22178646]
24. Qiao, Bo B and 6 more authors..  (2012)  Hepcidin-induced endocytosis of ferroportin is dependent on ferroportin ubiquitination..  Cell metabolism,    (6):   [PMID:22682227]
25. Rungaldier, Stefanie S, Oberwagner, Walter W, Salzer, Ulrich U, Csaszar, Edina E and Prohaska, Rainer R..  (2013)  Stomatin interacts with GLUT1/SLC2A1, band 3/SLC4A1, and aquaporin-1 in human erythrocyte membrane domains..  Biochimica et biophysica acta,      [PMID:23219802]
26. Mitchell, Colin J CJ, Shawki, Ali A, Ganz, Tomas T, Nemeth, Elizabeta E and Mackenzie, Bryan B..  (2014)  Functional properties of human ferroportin, a cellular iron exporter reactive also with cobalt and zinc..  American journal of physiology. Cell physiology,    (1):   [PMID:24304836]
27. Aschemeyer, Sharraya S and 13 more authors..  (2018)  Structure-function analysis of ferroportin defines the binding site and an alternative mechanism of action of hepcidin..  Blood,    (22):   [PMID:29237594]
28. Zhang, De-Liang DL and 11 more authors..  (2018)  Erythrocytic ferroportin reduces intracellular iron accumulation, hemolysis, and malaria risk..  Science (New York, N.Y.),    (30):   [PMID:29599243]
29. Choi, Eun-Kyung EK, Nguyen, Trang-Tiffany TT, Iwase, Shigeki S and Seo, Young Ah YA..  (2019)  Ferroportin disease mutations influence manganese accumulation and cytotoxicity..  FASEB journal : official publication of the Federation of American Societies for Experimental Biology,      [PMID:30247984]
30. Billesbølle, Christian B and 9 more authors..  (2020)  Structure of hepcidin-bound ferroportin reveals iron homeostatic mechanisms..  Nature,      [PMID:32814342]

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