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LY2940094 , CAS No.L611642, Antagonist of NOP receptor

  • Moligand™
Item Number
L611642
Grouped product items
SKUSizeAvailabilityPrice Qty
L611642-5mg
5mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$1,334.90
L611642-25mg
25mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$2,001.90
View related series
NOP receptor Antagonist

Basic Description

Synonyms1307245-86-8|LY2940094|LY-2940094|BTRX-246040|(2-(4-((2'-chloro-4',4'-difluoro-4',5'-dihydrospiro[piperidine-4,7'-thieno[2,3-c]pyran]-1-yl)methyl)-3-methyl-1H-pyrazol-1-yl)pyridin-3-yl)methanol|LY 2940094 - Bio-X|(2-(4-((2-Chloro-4,4-difluoro-spiro(5H-thi
GradeMoligand™
Action TypeANTAGONIST
Mechanism of actionAntagonist of NOP receptor

Associated Targets

OPRL1 Tchem Nociceptin receptor 1 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

Names and Identifiers

IUPAC Name [2-[4-[(2-chloro-4,4-difluorospiro[5H-thieno[2,3-c]pyran-7,4'-piperidine]-1'-yl)methyl]-3-methylpyrazol-1-yl]pyridin-3-yl]methanol
INCHI InChI=1S/C22H23ClF2N4O2S/c1-14-16(11-29(27-14)20-15(12-30)3-2-6-26-20)10-28-7-4-21(5-8-28)19-17(9-18(23)32-19)22(24,25)13-31-21/h2-3,6,9,11,30H,4-5,7-8,10,12-13H2,1H3
InChi Key NKQHBJNRBKHUQR-UHFFFAOYSA-N
Canonical SMILES OCc1cccnc1n1nc(c(c1)CN1CCC2(CC1)OCC(c1c2sc(c1)Cl)(F)F)C
Isomeric SMILES CC1=NN(C=C1CN2CCC3(CC2)C4=C(C=C(S4)Cl)C(CO3)(F)F)C5=C(C=CC=N5)CO
PubChem CID 52914971

Certificates

Certificate of Analysis(COA)

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Related Documents

References

1. Toledo MA, Pedregal C, Lafuente C, Diaz N, Martinez-Grau MA, Jiménez A, Benito A, Torrado A, Mateos C, Joshi EM et al..  (2014)  Discovery of a novel series of orally active nociceptin/orphanin FQ (NOP) receptor antagonists based on a dihydrospiro(piperidine-4,7'-thieno[2,3-c]pyran) scaffold..  J Med Chem,  57  (8): (3418-29).  [PMID:24678969]
2. Witkin JM, Rorick-Kehn LM, Benvenga MJ, Adams BL, Gleason SD, Knitowski KM, Li X, Chaney S, Falcone JF, Smith JW et al..  (2016)  Preclinical findings predicting efficacy and side-effect profile of LY2940094, an antagonist of nociceptin receptors..  Pharmacol Res Perspect,  (6): (e00275).  [PMID:28097008]
3. Post A, Smart TS, Krikke-Workel J, Dawson GR, Harmer CJ, Browning M, Jackson K, Kakar R, Mohs R, Statnick M et al..  (2016)  A Selective Nociceptin Receptor Antagonist to Treat Depression: Evidence from Preclinical and Clinical Studies..  Neuropsychopharmacology,  41  (7): (1803-12).  [PMID:26585287]
4. Post A, Smart TS, Jackson K, Mann J, Mohs R, Rorick-Kehn L, Statnick M, Anton R, O'Malley SS, Wong CJ.  (2016)  Proof-of-Concept Study to Assess the Nociceptin Receptor Antagonist LY2940094 as a New Treatment for Alcohol Dependence..  Alcohol Clin Exp Res,  40  (9): (1935-44).  [PMID:27435979]
5. Witkin JM, Wallace TL, Martin WJ.  (2019)  Therapeutic Approaches for NOP Receptor Antagonists in Neurobehavioral Disorders: Clinical Studies in Major Depressive Disorder and Alcohol Use Disorder with BTRX-246040 (LY2940094)..  Handb Exp Pharmacol,  254  (3): (399-415).  [PMID:30701317]
6. Ferrari F, Rizzo S, Ruzza C, Calo G.  (2020)  Detailed In Vitro Pharmacological Characterization of the Clinically Viable Nociceptin/Orphanin FQ Peptide Receptor Antagonist BTRX-246040..  J Pharmacol Exp Ther,  373  (1): (34-43).  [PMID:31937563]

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