LY339434 , CAS No.L611655, Agonist of GluK1;Agonist of GluK2

Item Number

L611655

Grouped product items
SKU	Size	Availability	Price	Qty
L611655-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$300.90
L611655-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,200.90

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Synonyms

LY 339434;LY-339434

Grade

Moligand™

Action Type

AGONIST

Mechanism of action

Agonist of GluK1;Agonist of GluK2

Associated Targets

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

IUPAC Name	2-amino-4-[(2E)-3-(naphthalen-2-yl)prop-2-en-1-yl]pentanedioic acid
INCHI	InChI=1S/C18H19NO4/c19-16(18(22)23)11-15(17(20)21)7-3-4-12-8-9-13-5-1-2-6-14(13)10-12/h1-6,8-10,15-16H,7,11,19H2,(H,20,21)(H,22,23)/b4-3+
InChi Key	KNAYYBRIBNEIAL-ONEGZZNKSA-N
Canonical SMILES	OC(=O)C(CC(C(=O)O)N)C/C=C/c1ccc2c(c1)cccc2
Isomeric SMILES	C1=CC=C2C=C(C=CC2=C1)/C=C/CC(CC(C(=O)O)N)C(=O)O
PubChem CID	69636646

References

1. Small B, Thomas J, Kemp M, Hoo K, Ballyk B, Deverill M, Ogden AM, Rubio A, Pedregal C, Bleakman D. (1998) LY339434, a GluR5 kainate receptor agonist.. Neuropharmacology, 37 (10-11): (1261-7). [PMID:9849663]
2. Pedregal C, Collado I, Escribano A, Ezquerra J, Domínguez C, Mateo AI, Rubio A, Baker SR, Goldsworthy J, Kamboj RK et al.. (2000) 4-Alkyl- and 4-cinnamylglutamic acid analogues are potent GluR5 kainate receptor agonists.. J Med Chem, 43 (10): (1958-68). [PMID:10821708]

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Basic Description