LY341495 - ≥98%, high purity , CAS No.201943-63-7, Antagonist of mGlu 1 receptor;Antagonist of mGlu 2 receptor;Agonist of mGlu 3 receptor;Antagonist of mGlu 3 receptor;Antagonist of mGlu 4 receptor;Antagonist of mGlu 5 receptor;Antagonist of mGlu 6 receptor;Antagonist of mGlu 7 receptor;Antagonist of mGlu
LY341495 - ≥98%, high purity , CAS No.201943-63-7, Antagonist of mGlu 1 receptor;Antagonist of mGlu 2 receptor;Agonist of mGlu 3 receptor;Antagonist of mGlu 3 receptor;Antagonist of mGlu 4 receptor;Antagonist of mGlu 5 receptor;Antagonist of mGlu 6 receptor;Antagonist of mGlu 7 receptor;Antagonist of mGlu
LY341495(LY 341495; LY-341495) is Highly potent and selective group II metabotropic glutamate receptor antagonist. (Ki/IC50 values are 2.3, 1.3, 173, 990, 6800, 8200 and 22000 nM for human mGlu2, mGlu3, mGlu8 , mGlu7a, mGlu1a, mGlu5a and mGlu4a receptors
Storage Temp
Store at -20°C
Shipped In
Ice chest + Ice pads
Grade
Moligand™
Action Type
AGONIST, ANTAGONIST
Mechanism of action
Antagonist of mGlu 1 receptor;Antagonist of mGlu 2 receptor;Agonist of mGlu 3 receptor;Antagonist of mGlu 3 receptor;Antagonist of mGlu 4 receptor;Antagonist of mGlu 5 receptor;Antagonist of mGlu 6 receptor;Antagonist of mGlu 7 receptor;Antagonist of mGlu
Note
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
1.Kingston AE, Ornstein PL, Wright RA, Johnson BG, Mayne NG, Burnett JP, Belagaje R, Wu S, Schoepp DD. (1998) LY341495 is a nanomolar potent and selective antagonist of group II metabotropic glutamate receptors.. Neuropharmacology, 37 (1):(1-12). [PMID:9680254]
2.Klar R et al.. (2015) Activation of Metabotropic Glutamate Receptor 7 Is Required for Induction of Long-Term Potentiation at SC-CA1 Synapses in the Hippocampus.. J Neurosci, 35 (19):(7600-15). [PMID:25972184]
3.Zhang P & Lisman JE. (2012) Activity-dependent regulation of synaptic strength by PSD-95 in CA1 neurons.. J Neurophysiol, 107 (4):(1058-66). [PMID:22114157]
4.Skov J et al.. (2011) Baclofen and adenosine inhibition of synaptic transmission at CA3-CA1 synapses display differential sensitivity to K+ channel blockade.. Cell Mol Neurobiol, 31 (4):(587-96). [PMID:21274618]
5.Bragina L et al.. (2015) Differential expression of metabotropic glutamate and GABA receptors at neocortical glutamatergic and GABAergic axon terminals.. Front Cell Neurosci, 9 (345). [PMID:26388733]
6.Mendis GDC et al.. (2019) Discovering the pharmacodynamics of conolidine and cannabidiol using a cultured neuronal network based workflow.. Sci Rep, 9 (121). [PMID:30644434]
7.Olofsson L et al.. (2014) Fine tuning of sub-millisecond conformational dynamics controls metabotropic glutamate receptors agonist efficacy.. Nat Commun, 5 (5206). [PMID:25323157]
8.Padamsey Z et al.. (2017) Glutamate is required for depression but not potentiation of long-term presynaptic function.. Elife, 6 [PMID:29140248]
9.Schauer C et al.. (2015) Hypothalamic gonadotropin-releasing hormone (GnRH) receptor neurons fire in synchrony with the female reproductive cycle.. J Neurophysiol, 114 (2):(1008-21). [PMID:26063780]
10.Robberechts Q et al.. (2010) Long-term depression at parallel fiber to Golgi cell synapses.. J Neurophysiol, 104 (6):(3413-23). [PMID:20861429]
11.Yamada K et al.. (2014) Neuronal activity regulates extracellular tau in vivo.. J Exp Med, 211 (3):(387-93). [PMID:24534188]
12.Avignone E et al.. (2008) Status epilepticus induces a particular microglial activation state characterized by enhanced purinergic signaling.. J Neurosci, 28 (37):(9133-44). [PMID:18784294]
13.Cuccurazzu B et al.. (2013) Upregulation of mGlu2 Receptors via NF-?B p65 Acetylation Is Involved in the Proneurogenic and Antidepressant Effects of Acetyl-L-Carnitine.. Neuropsychopharmacology, 38 (11):(2220-30). [PMID:23670591]
Solution Calculators
Molarity Calculator
Determine the necessary mass, volume, or concentration for preparing a solution.
Dilution Calculator
Determine the dilution needed to prepare a stock solution.
