Lys01 , CAS No.1391426-22-4

Item Number

L611681

Grouped product items
SKU	Size	Availability	Price	Qty
L611681-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,334.90
L611681-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$2,001.90

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Synonyms

compound 3a

Grade

Moligand™

Names and Identifiers

IUPAC Name	N-(7-chloroquinolin-4-yl)-N'-[2-[(7-chloroquinolin-4-yl)amino]ethyl]-N'-methylethane-1,2-diamine
INCHI	InChI=1S/C23H23Cl2N5/c1-30(12-10-28-20-6-8-26-22-14-16(24)2-4-18(20)22)13-11-29-21-7-9-27-23-15-17(25)3-5-19(21)23/h2-9,14-15H,10-13H2,1H3,(H,26,28)(H,27,29)
InChi Key	WDGQVCRQXSYPCW-UHFFFAOYSA-N
Canonical SMILES	CN(CCNC1=C2C=CC(=CC2=NC=C1)Cl)CCNC3=C4C=CC(=CC4=NC=C3)Cl
Isomeric SMILES	CN(CCNC1=C2C=CC(=CC2=NC=C1)Cl)CCNC3=C4C=CC(=CC4=NC=C3)Cl
PubChem CID	70673567
Molecular Weight	440.37

PubChem CID

ChEMBL Ligand

CAS Registry No.

References

1. McAfee Q, Zhang Z, Samanta A, Levi SM, Ma XH, Piao S, Lynch JP, Uehara T, Sepulveda AR, Davis LE et al.. (2012) Autophagy inhibitor Lys05 has single-agent antitumor activity and reproduces the phenotype of a genetic autophagy deficiency.. Proc Natl Acad Sci USA, 109 (21): (8253-8). [PMID:22566612]
2. Sakata Y, Yabunaka K, Kobayashi Y, Omiya H, Umezawa N, Kim HS, Wataya Y, Tomita Y, Hisamatsu Y, Kato N et al.. (2018) Potent Antimalarial Activity of Two Arenes Linked with Triamine Designed To Have Multiple Interactions with Heme.. ACS Med Chem Lett, 9 (10): (980-985). [PMID:30344903]

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Basic Description