MRTX0902 , CAS No.M612078, SOS Ras/Rac guanine nucleotide exchange factor 1

Item Number
M612078
Grouped product items
SKUSizeAvailabilityPrice Qty
M612078-5mg
5mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$750.90
M612078-25mg
25mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$2,034.90

Basic Description

SynonymsMRTX0902 | 2654743-22-1 | MRTX-0902 | CRG69FR93G | UNII-CRG69FR93G | CHEMBL5192659 | (R)-2-Methyl-3-(1-((4-methyl-7-morpholinopyrido(3,4-d)pyridazin-1-yl)amino)ethyl)benzonitrile | Benzonitrile, 2-methyl-3-((1R)-1-((4-methyl-7-(4-morpholinyl)pyrido(3,4-d)pyridazin-1-yl
Specifications & PurityMoligand™
GradeMoligand™
Mechanism of actionSOS Ras/Rac guanine nucleotide exchange factor 1

Associated Targets(Human)

SOS1 Tchem Son of sevenless homolog 1 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
EGFR Tclin Epidermal growth factor receptor erbB1 (33727 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
MIA PaCa-2 (5949 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SOS1 Tchem Son of sevenless homolog 1 (1023 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Names and Identifiers

INCHI InChI=1S/C22H24N6O/c1-14-17(12-23)5-4-6-18(14)15(2)25-22-19-11-21(28-7-9-29-10-8-28)24-13-20(19)16(3)26-27-22/h4-6,11,13,15H,7-10H2,1-3H3,(H,25,27)/t15-/m1/s1
InChi Key ILPWEAHQRAWJIU-OAHLLOKOSA-N
Canonical SMILES C[C@@H](Nc1nnc(C)c2c1cc(nc2)N1CCOCC1)c1cccc(C#N)c1C
Isomeric SMILES CC1=C(C=CC=C1[C@@H](C)NC2=NN=C(C3=CN=C(C=C32)N4CCOCC4)C)C#N
PubChem CID 156526655

Certificates

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Related Documents

References

1. Ketcham JM, Haling J, Khare S, Bowcut V, Briere DM, Burns AC, Gunn RJ, Ivetac A, Kuehler J, Kulyk S et al..  (2022)  Design and Discovery of MRTX0902, a Potent, Selective, Brain-Penetrant, and Orally Bioavailable Inhibitor of the SOS1:KRAS Protein-Protein Interaction..  J Med Chem,  129  (3): (589-97).  [PMID:35833726]
2. Hillig RC, Sautier B, Schroeder J, Moosmayer D, Hilpmann A, Stegmann CM, Werbeck ND, Briem H, Boemer U, Weiske J et al..  (2019)  Discovery of potent SOS1 inhibitors that block RAS activation via disruption of the RAS-SOS1 interaction..  Proc Natl Acad Sci USA,  116  (7): (2551-2560).  [PMID:30683722]
3. Hofmann MH, Gmachl M, Ramharter J, Savarese F, Gerlach D, Marszalek JR, Sanderson MP, Kessler D, Trapani F, Arnhof H et al..  (2021)  BI-3406, a Potent and Selective SOS1-KRAS Interaction Inhibitor, Is Effective in KRAS-Driven Cancers through Combined MEK Inhibition..  Cancer Discov,  11  (1): (142-157).  [PMID:32816843]

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