| SKU | Size | Availability | Price | Qty |
|---|---|---|---|---|
| M407956-1ml | 1ml | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $39.90 |
Fungal Inhibitors
| Specifications & Purity | 10mM in DMSO |
|---|---|
| Biochemical and Physiological Mechanisms | Magnolol (NSC 293099) is a bioactive lignin found in the bark of the Houpu magnolia (Magnolia officinalis) which shows antifungal properties. It can block TNF-α-induced NF-KB activation. |
| Storage Temp | Store at -80°C |
| Shipped In | Ice chest + Ice pads |
| Product Description | Information Magnolol Magnolol (NSC 293099) is a bioactive lignin found in the bark of the Houpu magnolia (Magnolia officinalis) which shows antifungal properties. It can block TNF-α-induced NF-KB activation. Magnolol is a bioactive lignin found in the bark of the Houpu magnolia (Magnolia officinalis) which shows antifungal properties. Magnolol preferentially increases (3)H-muscimol binding to hippocampus compared to cortex and cerebellum in vitro. Magnolol has a more potent enhancing effect on GABAA receptor alpha2 subunit. Magnolol shows significant inhibitory activities against Trichophyton mentagrophytes, Microsporium gypseum, Epidermophyton floccosum, Aspergillus niger, Cryptococcus neoformans, and Candida albicans with minimum inhibitory concentrations (MIC) in a range of 25-100 μg/ml. In vivo LD50: Mice 2200mg/kg (i.g.). cell lines：LNCaP/AR prostate cancer cell line Concentrations： Incubation Time： Powder Purity:≥99% |
| Canonical SMILES | OC1=C(C=C(CC=C)C=C1)C2=CC(=CC=C2O)CC=C |
|---|---|
| Molecular Weight | 266.33 |
Enter Lot Number to search for COA:
| Solubility | Solubility (25°C) In vitro DMSO: 100 mg/mL (148.9 mM); Ethanol: 4 mg/mL (5.95 mM); Water: Insoluble; |
|---|
| 1. Jietao Liu, Shenye Qu, Tao Wang, Bin Yang, Xiang Liu, Gaoxue Wang, Pengfei Li, Qing Yu, Fei Ling. (2024) Nanosuspensions as an approach for improved solubility and anti-Ichthyophthirius multifiliis activity of magnolol. AQUACULTURE, 579 (15): (740133). [PMID:10397721] |
| 2. Zhao Zhang, Jing Li, Gaoxue Wang, Fei Ling. (2023) The oral protective efficacy of magnolol against Aeromonas hydrophila and A. veronii infection via enhancing anti-inflammatory ability in goldfish (Carassius auratus). JOURNAL OF FISH DISEASES, 46 (12): (1413-1423). [PMID:37705318] |
| 3. Mo Feixu, Long Youhua, Li Ming, Ding Yi, Wu Shuai, Li Rongyu. (2023) Effect of enzyme-response Mag@CMCS@CPSG film on rice sheath blight disease (caused by Rhizoctonia solani) control and rice quality. Frontiers in Sustainable Food Systems, 7 [PMID:] |
| 4. Guoyu Wei, Wei Zhao, Anlong Hu, Mingjian Ren, Yunxiao Huang, Huayang Xu. (2023) Identification of a New Pathogenic fungi Causing Sorghum Leaf Spot Disease and Its Management Using Natural Product and Microorganisms. Microorganisms, 11 (6): (1431). [PMID:37374932] |
| 5. Tong Yin-Chao, Zhang Yi-Ning, Li Peng-Cheng, Cao Ya-Li, Ding Dong-Zhao, Yang Yang, Lin Qing-Yi, Gao Yi-Nuo, Sun Shao-Qiang, Fan Yun-Peng, Liu Ying-Qiu, Qing Su-Zhu, Ma Wu-Ren, Zhang Wei-Min. (2023) Detection of antibiotic-resistant canine origin Escherichia coli and the synergistic effect of magnolol in reducing the resistance of multidrug-resistant Escherichia coli. Frontiers in Veterinary Science, 10 [PMID:37008355] |
| 6. Feixu Mo, Wenzhi Li, Youhua Long, Rongyu Li, Yi Ding, Ming Li. (2023) Magnolol Loaded on Carboxymethyl Chitosan Particles Improved the Antimicrobial Resistance and Storability of Kiwifruits. Foods, 12 (6): (1149). [PMID:36981076] |
| 7. Weizhen Wang, Linan He, Zhuzhu Zhang, Wenzhi Li, Jia Chen, Tingting Chen, Youhua Long. (2023) Activity of the botanical compound thymol against kiwifruit rot caused by Fusarium tricinctum and the underlying mechanisms. PEST MANAGEMENT SCIENCE, [PMID:36864770] |
| 8. Chen Kai, Qin Ting, Pan Liangkun, Bing Xuwen, Xi Bingwen, Xie Jun. (2023) Effects of glycyrrhetinic acid β on growth and virulence of Aeromonas hydrophila. Frontiers in Microbiology, 14 [PMID:36846766] |
| 9. Ziyu Liu, Xiaoli Wang, Xingyue Zhu, Yazhou Tian, Jue Cheng, Junying Zhang. (2022) Phase Change Energy Storage Material with Photocuring, Photothermal Conversion, and Self-Cleaning Performance via a Two-Layer Structure. ACS Applied Materials & Interfaces, 14 (51): (57299–57310). [PMID:36514297] |
| 10. Xin-Yuan Jiang, Zong-Yi Ren, Nian-Kun Zhang, Ke-Chen Yang, Gao-Xue Wang, Hai-Feng Jiang. (2022) Screening and evaluating honokiol from Magnolia officinalis against Nocardia seriolae infection in largemouth bass (Micropterus Salmoides). JOURNAL OF FISH DISEASES, 45 (11): (1599-1607). [PMID:35801398] |
| 11. Ziyu Liu, Xingyue Zhu, Yazhou Tian, Kaiyun Zhou, Jue Cheng, Junying Zhang. (2022) Bio-based recyclable Form-Stable phase change material based on thermally reversible Diels–Alder reaction for sustainable thermal energy storage. CHEMICAL ENGINEERING JOURNAL, 448 (137749). [PMID:] |
| 12. Wenwen Guo, Fuwei Liang, Shun Chen, Kejing Yu, Jie Sun, Zengyuan Pang, Bin Fei. (2022) Magnolol-derived thiol-ene photo-polymerized membranes with intrinsic anti-flammability and high transparency. COMPOSITES PART B-ENGINEERING, 242 (110074). [PMID:] |
| 13. Wenwen Guo, Fuwei Liang, Shun Chen, Diantang Zhang, Wenbing Li, Kun Qian, Yang Xu, Bin Fei. (2022) Synthesis of magnolol-derived bisphosphate for fabrication of bismaleimide resins with intrinsic anti-flammability and smoke suppression. POLYMER DEGRADATION AND STABILITY, 202 (110002). [PMID:] |
| 14. Feixu Mo, Xianfeng Hu, Yi Ding, Rongyu Li, Youhua Long, Xiaomao Wu, Ming Li. (2021) Naturally produced magnolol can significantly damage the plasma membrane of Rhizoctonia solani. PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY, 178 (104942). [PMID:34446208] |
| 15. Xueying Song, Liu Liu, Xiaoxia Wu, Yongfeng Liu, Jialu Yuan. (2021) Chitosan-Based Functional Films Integrated with Magnolol: Characterization, Antioxidant and Antimicrobial Activity and Pork Preservation. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 22 (15): (7769). [PMID:34360535] |
| 16. Na Teng, Shimin Yang, Jinyue Dai, Shuaipeng Wang, Jun Zhao, Jin Zhu, Xiaoqing Liu. (2019) Making Benzoxazine Greener and Stronger: Renewable Resource, Microwave Irradiation, Green Solvent, and Excellent Thermal Properties. ACS Sustainable Chemistry & Engineering, 7 (9): (8715–8723). [PMID:] |
| 17. Jie Cheng, Shuqi Dong, Litao Yi, Di Geng, Qing Liu. (2018) Magnolol abrogates chronic mild stress-induced depressive-like behaviors by inhibiting neuroinflammation and oxidative stress in the prefrontal cortex of mice. INTERNATIONAL IMMUNOPHARMACOLOGY, 59 (61). [PMID:29627576] |
| 18. Zhihong Yao, Shishi Li, Zifei Qin, Xiaodan Hong, Yi Dai, Baojian Wu, Wencai Ye, Frank J. Gonzalez, Xinsheng Yao. (2017) Characterization of human UDP-glucuronosyltransferases responsible for glucuronidation and inhibition of norbakuchinic acid, a primary metabolite of hepatotoxicity and nephrotoxicity component bakuchiol in Psoralea corylifolia L.. RSC Advances, 7 (83): (52661-52671). [PMID:] |
| 19. Hongjun Zhang, Baoling Ju, Xiaoli Zhang, Yanfei Zhu, Ying Nie, Yuanhong Xu, Qiuxia Lei. (2017) Magnolol Attenuates Concanavalin A-induced Hepatic Fibrosis, Inhibits CD4+ T Helper 17 (Th17) Cell Differentiation and Suppresses Hepatic Stellate Cell Activation: Blockade of Smad3/Smad4 Signalling. BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY, 120 (6): (560-570). [PMID:28032440] |
| 20. Liu Guishen, Ma Yanhui, Hou Xiaodong, huang Yina, Chen Jianpeng, Zhan Guoqing, Li Chunya. (2015) Synthesis of 1-[3-(N-pyrrole)propyl]-3-[1-tert-butoxycarbonylamino-propyl]-imidazolium tetrafluoroborate ionic liquid for application in electrochemical sensing of magnolol. IONICS, 21 (9): (2567-2574). [PMID:] |
| 21. Zhenhao Li, Shun Xiao, Ni Ai, Kedi Luo, Xiaohui Fan, Yiyu Cheng. (2015) Derivative multiple reaction monitoring and single herb calibration approach for multiple components quantification of traditional Chinese medicine analogous formulae. JOURNAL OF CHROMATOGRAPHY A, 1376 (126). [PMID:25541090] |
| 22. Xinjian Song, Bing Wang, Yina Huang, Liqing Li, Ting Li, Chunya Li, Shenghui Zhang. (2014) A novel nanoporous film electrode based on electrochemical polymerization of ionic liquid and its application in sensitive determination of magnolol. TALANTA, 119 (606). [PMID:24401462] |
| 23. Xu T,Zheng Z,Guo Y,Bai LP. (2020) Semisynthesis of novel magnolol-based Mannich base derivatives that suppress cancer cells via inducing autophagy.. Eur J Med Chem, 205 (112663-112663). [PMID:32791403] |
| 1. Jietao Liu, Shenye Qu, Tao Wang, Bin Yang, Xiang Liu, Gaoxue Wang, Pengfei Li, Qing Yu, Fei Ling. (2024) Nanosuspensions as an approach for improved solubility and anti-Ichthyophthirius multifiliis activity of magnolol. AQUACULTURE, 579 (15): (740133). [PMID:10397721] |
| 2. Zhao Zhang, Jing Li, Gaoxue Wang, Fei Ling. (2023) The oral protective efficacy of magnolol against Aeromonas hydrophila and A. veronii infection via enhancing anti-inflammatory ability in goldfish (Carassius auratus). JOURNAL OF FISH DISEASES, 46 (12): (1413-1423). [PMID:37705318] |
| 3. Mo Feixu, Long Youhua, Li Ming, Ding Yi, Wu Shuai, Li Rongyu. (2023) Effect of enzyme-response Mag@CMCS@CPSG film on rice sheath blight disease (caused by Rhizoctonia solani) control and rice quality. Frontiers in Sustainable Food Systems, 7 [PMID:] |
| 4. Guoyu Wei, Wei Zhao, Anlong Hu, Mingjian Ren, Yunxiao Huang, Huayang Xu. (2023) Identification of a New Pathogenic fungi Causing Sorghum Leaf Spot Disease and Its Management Using Natural Product and Microorganisms. Microorganisms, 11 (6): (1431). [PMID:37374932] |
| 5. Tong Yin-Chao, Zhang Yi-Ning, Li Peng-Cheng, Cao Ya-Li, Ding Dong-Zhao, Yang Yang, Lin Qing-Yi, Gao Yi-Nuo, Sun Shao-Qiang, Fan Yun-Peng, Liu Ying-Qiu, Qing Su-Zhu, Ma Wu-Ren, Zhang Wei-Min. (2023) Detection of antibiotic-resistant canine origin Escherichia coli and the synergistic effect of magnolol in reducing the resistance of multidrug-resistant Escherichia coli. Frontiers in Veterinary Science, 10 [PMID:37008355] |
| 6. Feixu Mo, Wenzhi Li, Youhua Long, Rongyu Li, Yi Ding, Ming Li. (2023) Magnolol Loaded on Carboxymethyl Chitosan Particles Improved the Antimicrobial Resistance and Storability of Kiwifruits. Foods, 12 (6): (1149). [PMID:36981076] |
| 7. Weizhen Wang, Linan He, Zhuzhu Zhang, Wenzhi Li, Jia Chen, Tingting Chen, Youhua Long. (2023) Activity of the botanical compound thymol against kiwifruit rot caused by Fusarium tricinctum and the underlying mechanisms. PEST MANAGEMENT SCIENCE, [PMID:36864770] |
| 8. Chen Kai, Qin Ting, Pan Liangkun, Bing Xuwen, Xi Bingwen, Xie Jun. (2023) Effects of glycyrrhetinic acid β on growth and virulence of Aeromonas hydrophila. Frontiers in Microbiology, 14 [PMID:36846766] |
| 9. Ziyu Liu, Xiaoli Wang, Xingyue Zhu, Yazhou Tian, Jue Cheng, Junying Zhang. (2022) Phase Change Energy Storage Material with Photocuring, Photothermal Conversion, and Self-Cleaning Performance via a Two-Layer Structure. ACS Applied Materials & Interfaces, 14 (51): (57299–57310). [PMID:36514297] |
| 10. Xin-Yuan Jiang, Zong-Yi Ren, Nian-Kun Zhang, Ke-Chen Yang, Gao-Xue Wang, Hai-Feng Jiang. (2022) Screening and evaluating honokiol from Magnolia officinalis against Nocardia seriolae infection in largemouth bass (Micropterus Salmoides). JOURNAL OF FISH DISEASES, 45 (11): (1599-1607). [PMID:35801398] |
| 11. Ziyu Liu, Xingyue Zhu, Yazhou Tian, Kaiyun Zhou, Jue Cheng, Junying Zhang. (2022) Bio-based recyclable Form-Stable phase change material based on thermally reversible Diels–Alder reaction for sustainable thermal energy storage. CHEMICAL ENGINEERING JOURNAL, 448 (137749). [PMID:] |
| 12. Wenwen Guo, Fuwei Liang, Shun Chen, Kejing Yu, Jie Sun, Zengyuan Pang, Bin Fei. (2022) Magnolol-derived thiol-ene photo-polymerized membranes with intrinsic anti-flammability and high transparency. COMPOSITES PART B-ENGINEERING, 242 (110074). [PMID:] |
| 13. Wenwen Guo, Fuwei Liang, Shun Chen, Diantang Zhang, Wenbing Li, Kun Qian, Yang Xu, Bin Fei. (2022) Synthesis of magnolol-derived bisphosphate for fabrication of bismaleimide resins with intrinsic anti-flammability and smoke suppression. POLYMER DEGRADATION AND STABILITY, 202 (110002). [PMID:] |
| 14. Feixu Mo, Xianfeng Hu, Yi Ding, Rongyu Li, Youhua Long, Xiaomao Wu, Ming Li. (2021) Naturally produced magnolol can significantly damage the plasma membrane of Rhizoctonia solani. PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY, 178 (104942). [PMID:34446208] |
| 15. Xueying Song, Liu Liu, Xiaoxia Wu, Yongfeng Liu, Jialu Yuan. (2021) Chitosan-Based Functional Films Integrated with Magnolol: Characterization, Antioxidant and Antimicrobial Activity and Pork Preservation. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 22 (15): (7769). [PMID:34360535] |
| 16. Na Teng, Shimin Yang, Jinyue Dai, Shuaipeng Wang, Jun Zhao, Jin Zhu, Xiaoqing Liu. (2019) Making Benzoxazine Greener and Stronger: Renewable Resource, Microwave Irradiation, Green Solvent, and Excellent Thermal Properties. ACS Sustainable Chemistry & Engineering, 7 (9): (8715–8723). [PMID:] |
| 17. Jie Cheng, Shuqi Dong, Litao Yi, Di Geng, Qing Liu. (2018) Magnolol abrogates chronic mild stress-induced depressive-like behaviors by inhibiting neuroinflammation and oxidative stress in the prefrontal cortex of mice. INTERNATIONAL IMMUNOPHARMACOLOGY, 59 (61). [PMID:29627576] |
| 18. Zhihong Yao, Shishi Li, Zifei Qin, Xiaodan Hong, Yi Dai, Baojian Wu, Wencai Ye, Frank J. Gonzalez, Xinsheng Yao. (2017) Characterization of human UDP-glucuronosyltransferases responsible for glucuronidation and inhibition of norbakuchinic acid, a primary metabolite of hepatotoxicity and nephrotoxicity component bakuchiol in Psoralea corylifolia L.. RSC Advances, 7 (83): (52661-52671). [PMID:] |
| 19. Hongjun Zhang, Baoling Ju, Xiaoli Zhang, Yanfei Zhu, Ying Nie, Yuanhong Xu, Qiuxia Lei. (2017) Magnolol Attenuates Concanavalin A-induced Hepatic Fibrosis, Inhibits CD4+ T Helper 17 (Th17) Cell Differentiation and Suppresses Hepatic Stellate Cell Activation: Blockade of Smad3/Smad4 Signalling. BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY, 120 (6): (560-570). [PMID:28032440] |
| 20. Liu Guishen, Ma Yanhui, Hou Xiaodong, huang Yina, Chen Jianpeng, Zhan Guoqing, Li Chunya. (2015) Synthesis of 1-[3-(N-pyrrole)propyl]-3-[1-tert-butoxycarbonylamino-propyl]-imidazolium tetrafluoroborate ionic liquid for application in electrochemical sensing of magnolol. IONICS, 21 (9): (2567-2574). [PMID:] |
| 21. Zhenhao Li, Shun Xiao, Ni Ai, Kedi Luo, Xiaohui Fan, Yiyu Cheng. (2015) Derivative multiple reaction monitoring and single herb calibration approach for multiple components quantification of traditional Chinese medicine analogous formulae. JOURNAL OF CHROMATOGRAPHY A, 1376 (126). [PMID:25541090] |
| 22. Xinjian Song, Bing Wang, Yina Huang, Liqing Li, Ting Li, Chunya Li, Shenghui Zhang. (2014) A novel nanoporous film electrode based on electrochemical polymerization of ionic liquid and its application in sensitive determination of magnolol. TALANTA, 119 (606). [PMID:24401462] |
| 23. Xu T,Zheng Z,Guo Y,Bai LP. (2020) Semisynthesis of novel magnolol-based Mannich base derivatives that suppress cancer cells via inducing autophagy.. Eur J Med Chem, 205 (112663-112663). [PMID:32791403] |
