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Mal-PEG2-Val-Cit-PAB-OH - 95%, high purity , CAS No.2055041-38-6

Item Number

M596148

Grouped product items
SKU	Size	Availability	Price
M596148-10mg	10mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$361.90
M596148-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$721.90
M596148-50mg	50mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,141.90

Val-Cit

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Basic Description

Specifications & Purity	95%
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Product Description	Mal-PEG2-Val-Cit-PAB-OH is a cleavable ADC linker. The Val-Cit will specifically be cleaved by Cathepsin B. As this enzyme is only present in the lysosome, the ADC payload will be released only in the cell. The maleimide group is reactive toward thiol groups between pH 6.5 to 7.5. The hydroxyl group can be reacted to further derivatize the compound. The hydrophobic PEG chain increases the water solubility of the compound.

Molecular Weight	618.7

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Solubility	Solubility in DMSO, DMF

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