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Mal-PEG4-Val-Cit-PAB-OH - 96%, high purity , CAS No.2055041-39-7

Item Number

M596149

Grouped product items
SKU	Size	Availability	Price
M596149-50mg	50mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,351.90
M596149-100mg	100mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$2,041.90
M596149-250mg	250mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$2,941.90

Val-Cit

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Basic Description

Specifications & Purity	96%
Storage Temp	Store at -20°C
Shipped In	Dry ice
Product Description	Mal-PEG4-Val-Cit-PAB-OH is a cleavable ADC linker. The Val-Cit will specifically be cleaved by Cathepsin B. As this enzyme is only present in the lysosome, the ADC payload will be released only in the cell. The maleimide group is reactive toward thiol groups between pH 6.5 to 7.5. The hydroxyl group can be reacted to further derivatize the compound. The hydrophobic PEG chain increases the water solubility of the compound.

Molecular Weight	706.8

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Solubility	Solubility in DMSO, DCM, DMF

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