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MAP4 - ≥96%(HPLC), high purity , CAS No.157381-42-5, Antagonist of mGlu 4 receptor;Antagonist of mGlu 6 receptor;Antagonist of mGlu 7 receptor;Antagonist of mGlu 8 receptor

Moligand™
≥96%(HPLC)

CAS#: 157381-42-5
Formula: C₅H₁₂NO₅P
Molecular Weight: 197.13
PubChem CID: 1795545

Item Number

M288456

Grouped product items
SKU	Size	Availability	Price	Qty
M288456-10mg	10mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$205.90
M288456-50mg	50mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$846.90

Potent group II mGlu agonist; also group III mGlu antagonist

View related series

mGlu4 receptor Antagonist mGlu6 receptor Antagonist mGlu7 receptor Antagonist mGlu8 receptor Antagonist

Basic Description

Synonyms	MAP4\|157381-42-5\|(S)-2-Amino-2-methyl-4-phosphonobutanoic acid\|(2S)-2-amino-2-methyl-4-phosphonobutanoic acid\|L-Isovaline, 4-phosphono-\|(S)-MAP4\|Tocris-0711\|4-Phosphono-L-isovaline\|SCHEMBL179781\|GTPL1414\|CHEMBL1488784\|DTXSID40935660\|AKOS006272533\|NCGC0002
Specifications & Purity	Moligand™, ≥96%(HPLC)
Biochemical and Physiological Mechanisms	Selective group III metabotropic glutamate receptor antagonist in some electrophysiological systems. Group II/group III agonist in certain neurochemical systems.
Storage Temp	Room temperature
Shipped In	Normal
Grade	Moligand™
Action Type	ANTAGONIST
Mechanism of action	Antagonist of mGlu 4 receptor;Antagonist of mGlu 6 receptor;Antagonist of mGlu 7 receptor;Antagonist of mGlu 8 receptor

Associated Targets

CYP1A2 Tchem Cytochrome P450 1A2 0 Activities

Discover Target: CYP1A2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CYP2D6 Tclin Cytochrome P450 2D6 0 Activities

Discover Target: CYP2D6

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CYP2C19 Tchem Cytochrome P450 2C19 0 Activities

Discover Target: CYP2C19

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CYP3A4 Tclin Cytochrome P450 3A4 0 Activities

Discover Target: CYP3A4

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CYP2C9 Tchem Cytochrome P450 2C9 0 Activities

Discover Target: CYP2C9

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

KAT2A Tchem Histone acetyltransferase KAT2A 0 Activities

Discover Target: KAT2A

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

ALDH1A1 Tchem Retinal dehydrogenase 1 0 Activities

Discover Target: ALDH1A1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

MAPT Tclin Microtubule-associated protein tau 0 Activities

Discover Target: MAPT

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

GRM4 Tchem Metabotropic glutamate receptor 4 1 Activities

Discover Target: GRM4

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

GRM7 Tchem Metabotropic glutamate receptor 7 1 Activities

Discover Target: GRM7

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

GRM8 Tchem Metabotropic glutamate receptor 8 0 Activities

Discover Target: GRM8

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

GRM6 Tchem Metabotropic glutamate receptor 6 1 Activities

Discover Target: GRM6

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

IUPAC Name	(2S)-2-amino-2-methyl-4-phosphonobutanoic acid
INCHI	InChI=1S/C5H12NO5P/c1-5(6,4(7)8)2-3-12(9,10)11/h2-3,6H2,1H3,(H,7,8)(H2,9,10,11)/t5-/m0/s1
InChi Key	HONKEGXLWUDTCF-YFKPBYRVSA-N
Canonical SMILES	CC(CCP(=O)(O)O)(C(=O)O)N
Isomeric SMILES	C[C@](CCP(=O)(O)O)(C(=O)O)N
PubChem CID	1795545
Molecular Weight	197.13

CAS Registry No.

PubChem CID

ChEMBL Ligand

GPCRdb Ligand

Safety and Hazards(GHS)

Pictogram(s)	GHS07
Signal	Warning
Hazard Statements	H315:Causes skin irritation H319:Causes serious eye irritation H335:May cause respiratory irritation
Precautionary Statements	P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P271:Use only outdoors or in a well-ventilated area. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P362+P364:Take off contaminated clothing and wash it before reuse. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P337+P317:If eye irritation persists: Get medical help. P332+P317:If skin irritation occurs: Get medical help. P319:Get medical help if you feel unwell.

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