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CMGC:Containing CDK, MAPK, GSK3, CLK families
MAPK13-IN-1 , CAS No.M611730, Inhibitor of mitogen-activated protein kinase 13;Inhibitor of mitogen-activated protein kinase 14

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MAPK13-IN-1 , CAS No.M611730, Inhibitor of mitogen-activated protein kinase 13;Inhibitor of mitogen-activated protein kinase 14

Moligand™

PubChem CID: 17941505

Item Number

M611730

Grouped product items
SKU	Size	Availability	Price	Qty
M611730-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,300.90
M611730-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$2,000.90

View related series

mitogen-activated protein kinase 13 Inhibitor mitogen-activated protein kinase 14 Inhibitor

Basic Description

Synonyms	compound 61 [WO2014015056A2]
Specifications & Purity	Moligand™
Grade	Moligand™
Action Type	INHIBITOR
Mechanism of action	Inhibitor of mitogen-activated protein kinase 13;Inhibitor of mitogen-activated protein kinase 14

Associated Targets

RAF1 Tclin RAF proto-oncogene serine/threonine-protein kinase 0 Activities

Discover Target: RAF1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

MAPK13 Tchem Mitogen-activated protein kinase 13 0 Activities

Discover Target: MAPK13

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

MAPK14 Tchem Mitogen-activated protein kinase 14 0 Activities

Discover Target: MAPK14

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

IUPAC Name	1-(5-tert-butyl-2-methylpyrazol-3-yl)-3-(4-pyridin-4-yloxyphenyl)urea
INCHI	InChI=1S/C20H23N5O2/c1-20(2,3)17-13-18(25(4)24-17)23-19(26)22-14-5-7-15(8-6-14)27-16-9-11-21-12-10-16/h5-13H,1-4H3,(H2,22,23,26)
InChi Key	MHSLDASSAFCCDO-UHFFFAOYSA-N
Canonical SMILES	O=C(Nc1cc(nn1C)C(C)(C)C)Nc1ccc(cc1)Oc1ccncc1
Isomeric SMILES	CC(C)(C)C1=NN(C(=C1)NC(=O)NC2=CC=C(C=C2)OC3=CC=NC=C3)C
PubChem CID	17941505

Database links

PubChem CID	17941505
ChEMBL Ligand	CHEMBL472620
BindingDB Ligand	50249406
RCSB PDB Ligand	N61

Certificates

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References

1. Alevy YG, Patel AC, Romero AG, Patel DA, Tucker J, Roswit WT, Miller CA, Heier RF, Byers DE, Brett TJ et al.. (2012) IL-13-induced airway mucus production is attenuated by MAPK13 inhibition.. J Clin Invest, 122 (12): (4555-68). [PMID:23187130]

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