Skip to the beginning of the images gallery

MaxiPost - ≥98%(HPLC), high purity , Voltage-gated potassium channel KCNQ3/KCNQ4 activator, CAS No.187523-35-9, Voltage-gated potassium channel KCNQ3/KCNQ4 activator

Moligand™
≥98%(HPLC)

CAS#: 187523-35-9
Formula: C₁₆H₁₀ClF₄NO₂
Molecular Weight: 359.7
PubChem CID: 214350

Item Number

M287135

Grouped product items
SKU	Size	Availability	Price
M287135-1mg	1mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$50.90
M287135-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$121.90
M287135-10mg	10mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$226.90
M287135-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$376.90
M287135-50mg	50mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$840.90

Potassium channel modulator; exerts subtype-specific effects

View related series

KCa1.1 Activator Kv7.2 Activator Kv7.4 Activator Kv7.5 Activator Potassium Channel

Basic Description

Synonyms	Flindokalner\|187523-35-9\|MaxiPost\|BMS-204352\|BMS 204352\|(3S)-3-(5-Chloro-2-methoxyphenyl)-3-fluoro-6-(trifluoromethyl)-1,3-dihydro-2H-indol-2-one\|J57O328W4W\|Maxipost (TN)\|(3S)-3-(5-chloro-2-methoxyphenyl)-3-fluoro-6-(trifluoromethyl)-1H-indol-2-one\|2H-Ind
Specifications & Purity	Moligand™, ≥98%(HPLC)
Biochemical and Physiological Mechanisms	Potassium channel modulator. Acts as a positive modulator at neuronal Kv7 channels and calcium-activated K+channels (BKCa) in HEK293 cells. Displays negative modulatory activity at Kv7.1 channels (Ki= 3.7μM) and GABAAreceptors. Displays anxiolytic activit
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Grade	Moligand™
Action Type	ACTIVATOR, OPENER
Mechanism of action	Voltage-gated potassium channel KCNQ3/KCNQ4 activator

Associated Targets

HDAC6 Tclin Histone deacetylase 6 0 Activities

Discover Target: HDAC6

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

KCNQ4 Tclin Potassium voltage-gated channel subfamily KQT member 4 2 Activities

Discover Target: KCNQ4

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

KCNQ5 Tclin Potassium voltage-gated channel subfamily KQT member 5 2 Activities

Discover Target: KCNQ5

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

UGT2B7 Tchem UDP-glucuronosyltransferase 2B7 0 Activities

Discover Target: UGT2B7

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

ABCC2 Tchem Canalicular multispecific organic anion transporter 1 0 Activities

Discover Target: ABCC2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

ABCC3 Tbio Canalicular multispecific organic anion transporter 2 0 Activities

Discover Target: ABCC3

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

ABCC4 Tchem Multidrug resistance-associated protein 4 0 Activities

Discover Target: ABCC4

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

ABCB11 Tchem Bile salt export pump 0 Activities

Discover Target: ABCB11

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

KCNQ2 Tclin Potassium voltage-gated channel subfamily KQT member 2 2 Activities

Discover Target: KCNQ2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

KCND3 Tclin Potassium voltage-gated channel subfamily D member 3 0 Activities

Discover Target: KCND3

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

KCNMA1 Tclin Calcium-activated potassium channel subunit alpha-1 2 Activities

Discover Target: KCNMA1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

KCNQ3 Tclin Potassium voltage-gated channel subfamily KQT member 3 1 Activities

Discover Target: KCNQ3

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

IUPAC Name	(3S)-3-(5-chloro-2-methoxyphenyl)-3-fluoro-6-(trifluoromethyl)-1H-indol-2-one
INCHI	InChI=1S/C16H10ClF4NO2/c1-24-13-5-3-9(17)7-11(13)15(18)10-4-2-8(16(19,20)21)6-12(10)22-14(15)23/h2-7H,1H3,(H,22,23)/t15-/m0/s1
InChi Key	ULYONBAOIMCNEH-HNNXBMFYSA-N
Canonical SMILES	COC1=C(C=C(C=C1)Cl)C2(C3=C(C=C(C=C3)C(F)(F)F)NC2=O)F
Isomeric SMILES	COC1=C(C=C(C=C1)Cl)[C@]2(C3=C(C=C(C=C3)C(F)(F)F)NC2=O)F
RTECS	NM3249000
PubChem CID	214350
Molecular Weight	359.7

PubChem CID

214350

ChEMBL Ligand

CHEMBL266510

CAS Registry No.

187523-35-9

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

To view the certificate results,please click on a Lot number.For Lot numbers from past orders,please use our order status section

10 results found

Lot Number	Certificate Type	Date	Item
A2426276	Certificate of Analysis	Dec 25, 2023	M287135
A2426277	Certificate of Analysis	Dec 25, 2023	M287135
A2426278	Certificate of Analysis	Dec 25, 2023	M287135
A2426279	Certificate of Analysis	Dec 25, 2023	M287135
A2426280	Certificate of Analysis	Dec 25, 2023	M287135
A2426281	Certificate of Analysis	Dec 25, 2023	M287135
A2426282	Certificate of Analysis	Dec 25, 2023	M287135
A2426283	Certificate of Analysis	Dec 25, 2023	M287135
A2426284	Certificate of Analysis	Dec 25, 2023	M287135
A2426285	Certificate of Analysis	Dec 25, 2023	M287135

RTECS

NM3249000

RIDADR

NONHforallmodesoftransport

Solution Calculators

Molarity Calculator

Determine the necessary mass, volume, or concentration for preparing a solution.

Dilution Calculator

Determine the dilution needed to prepare a stock solution.