Maytansinoid B is a kind of ADC Cytotoxin. Maytansinoid B can be used to conjugates with antibodies to form antibody-drug conjugates (ADCs). Maytansinoids are known as antimitotic agents, binding to tubulin and inhibiting microtubule assembly. Maytansinoids induces G2/M arrest in the cell cycle to induce apoptosis.
In Vitro
Maytansinoids exhibits cytotoxic activity with 10-90 pM range across several tumor cell lines, including lymphoma lines. Maytansinoid conjugates with anti-CD9, to form SAR3419 against B-cell malignancies. MCE has not independently confirmed the accuracy of these methods. They are for reference only.
