JavaScript seems to be disabled in your browser. For the best experience on our site, be sure to turn on Javascript in your browser.

྾

MB 0223 - ≥98%(HPLC), high purity , CAS No.2247732-89-2

Item Number

M288737

Grouped product items
SKU	Size	Availability	Price	Qty
M288737-10mg	10mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$189.90
M288737-50mg	50mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$797.90

Dynamin-related GTPase DRP1 partial inhibitor

Basic Description

Synonyms	4-Methyl-1-((2-(piperidin-1-yl)thiazol-4-yl)methyl)-N-(4-(pyridin-3-yl)phenyl)-1H-pyrrole-2-carboxamide
Specifications & Purity	≥98%(HPLC)
Biochemical and Physiological Mechanisms	Dynamin-related GTPase DRP1 partial inhibitor (IC50= 1.2 μM). Selective for DRP1 over other dynamin-related GTPases, OPA1 and DYN1. Increases mitochondrial DNA levels inmfn1-knockout MEFs deficient in mitochondrial fusion.
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

IUPAC Name	4-methyl-1-[(2-piperidin-1-yl-1,3-thiazol-4-yl)methyl]-N-(4-pyridin-3-ylphenyl)pyrrole-2-carboxamide
INCHI	InChI=1S/C26H27N5OS/c1-19-14-24(25(32)28-22-9-7-20(8-10-22)21-6-5-11-27-15-21)31(16-19)17-23-18-33-26(29-23)30-12-3-2-4-13-30/h5-11,14-16,18H,2-4,12-13,17H2,1H3,(H,28,32)
InChi Key	SWLKFZCOJAYAMJ-UHFFFAOYSA-N
Canonical SMILES	CC1=CN(C(=C1)C(=O)NC2=CC=C(C=C2)C3=CN=CC=C3)CC4=CSC(=N4)N5CCCCC5
Isomeric SMILES	CC1=CN(C(=C1)C(=O)NC2=CC=C(C=C2)C3=CN=CC=C3)CC4=CSC(=N4)N5CCCCC5
PubChem CID	135368613
Molecular Weight	457.59

Enter Lot Number to search for COA:

Solubility	Solvent:DMSO, Max Conc. mg/mL: 45.76, Max Conc. mM: 100

Determine the necessary mass, volume, or concentration for preparing a solution.

Determine the dilution needed to prepare a stock solution.