MB-3 , CAS No.M611752, Inhibitor of lysine acetyltransferase 2B

Item Number

M611752

Grouped product items
SKU	Size	Availability	Price	Qty
M611752-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,300.90
M611752-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$2,000.90

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Synonyms

α-methylene-γ-butyrolactone 3

Grade

Moligand™

Action Type

INHIBITOR

Mechanism of action

Inhibitor of lysine acetyltransferase 2B

Names and Identifiers

IUPAC Name	(2S,3S)-4,5-dioxo-2-propyloxolane-3-carboxylic acid
INCHI	InChI=1S/C8H10O5/c1-2-3-4-5(7(10)11)6(9)8(12)13-4/h4-5H,2-3H2,1H3,(H,10,11)/t4-,5-/m0/s1
InChi Key	AKWJFOMNTDKSRR-WHFBIAKZSA-N
Canonical SMILES	CCC[C@@H]1OC(=O)C(=O)[C@H]1C(=O)O
Isomeric SMILES	CCC[C@H]1[C@@H](C(=O)C(=O)O1)C(=O)O
PubChem CID	91827357

References

1. Lee KK, Workman JL. (2007) Histone acetyltransferase complexes: one size doesn't fit all.. Nat Rev Mol Cell Biol, 8 (4): (284-95). [PMID:17380162]
2. Biel M, Kretsovali A, Karatzali E, Papamatheakis J, Giannis A. (2004) Design, synthesis, and biological evaluation of a small-molecule inhibitor of the histone acetyltransferase Gcn5.. Angew Chem Int Ed Engl, 43 (30): (3974-6). [PMID:15274229]
3. Holmlund T, Lindberg MJ, Grander D, Wallberg AE. (2013) GCN5 acetylates and regulates the stability of the oncoprotein E2A-PBX1 in acute lymphoblastic leukemia.. Leukemia, 27 (3): (578-85). [PMID:23044487]
4. Carroll AJ, Crist WM, Parmley RT, Roper M, Cooper MD, Finley WH. (1984) Pre-B cell leukemia associated with chromosome translocation 1;19.. Blood, 63 (3): (721-4). [PMID:6607758]
5. Dahlin JL, Nelson KM, Strasser JM, Barsyte-Lovejoy D, Szewczyk MM, Organ S, Cuellar M, Singh G, Shrimp JH, Nguyen N et al.. (2017) Assay interference and off-target liabilities of reported histone acetyltransferase inhibitors.. Nat Commun, 8 (1): (1527). [PMID:29142305]

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