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MBX-2982 - ≥98%, high purity , Glucose-dependent insulinotropic receptor agonist, CAS No.1037792-44-1, Glucose-dependent insulinotropic receptor agonist

Moligand™
≥98%

CAS#: 1037792-44-1
Formula: C₂₂H₂₄N₈OS
Molecular Weight: 448.54
PubChem CID: 25025505

Item Number

M127623

Grouped product items
SKU	Size	Availability	Price
M127623-5mg	5mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$278.90
M127623-10mg	10mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$470.90
M127623-25mg	25mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$1,059.90
M127623-50mg	50mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$1,611.90

View related series

GPR119 Agonist

Basic Description

Synonyms	MBX-2982\|1037792-44-1\|4-((4-(1H-tetrazol-1-yl)phenoxy)methyl)-2-(1-(5-ethylpyrimidin-2-yl)piperidin-4-yl)thiazole\|MBX2982\|2-[1-(5-ethylpyrimidin-2-yl)-4-piperidyl]-4-[[4-(tetrazol-1-yl)phenoxy]methyl]thiazole\|B5TRY67L51\|CHEMBL3260505\|2-[1-(5-ethylpyrimidi
Specifications & Purity	Moligand™, ≥98%
Biochemical and Physiological Mechanisms	MBX-2982 is a potential first-in-class treatment for type 2 diabetes that targets G protein-coupled receptor 119 (GPR119), a receptor that interacts with bioactive lipids known to stimulate glucose-dependent insulin secretion. Preclinical data indicate th
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Grade	Moligand™
Action Type	AGONIST
Mechanism of action	Glucose-dependent insulinotropic receptor agonist
Note	卖完停产，不再备货
Product Description	MBX-2982 is a selective, orally-available GPR119 agonist for the treatment of type 2 tiabetes.

Associated Targets

CYP1A2 Tchem Cytochrome P450 1A2 0 Activities

Discover Target: CYP1A2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CYP2D6 Tclin Cytochrome P450 2D6 0 Activities

Discover Target: CYP2D6

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CYP2C19 Tchem Cytochrome P450 2C19 0 Activities

Discover Target: CYP2C19

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CYP2A6 Tchem Cytochrome P450 2A6 0 Activities

Discover Target: CYP2A6

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CYP3A4 Tclin Cytochrome P450 3A4 0 Activities

Discover Target: CYP3A4

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

HDAC6 Tclin Histone deacetylase 6 0 Activities

Discover Target: HDAC6

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

GPR119 Tclin Glucose-dependent insulinotropic receptor 3 Activities

Discover Target: GPR119

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

KCNH2 Tclin Potassium voltage-gated channel subfamily H member 2 0 Activities

Discover Target: KCNH2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

IUPAC Name	2-[1-(5-ethylpyrimidin-2-yl)piperidin-4-yl]-4-[[4-(tetrazol-1-yl)phenoxy]methyl]-1,3-thiazole
INCHI	InChI=1S/C22H24N8OS/c1-2-16-11-23-22(24-12-16)29-9-7-17(8-10-29)21-26-18(14-32-21)13-31-20-5-3-19(4-6-20)30-15-25-27-28-30/h3-6,11-12,14-15,17H,2,7-10,13H2,1H3
InChi Key	NFTMKHWBOINJGM-UHFFFAOYSA-N
Canonical SMILES	CCC1=CN=C(N=C1)N2CCC(CC2)C3=NC(=CS3)COC4=CC=C(C=C4)N5C=NN=N5
Isomeric SMILES	CCC1=CN=C(N=C1)N2CCC(CC2)C3=NC(=CS3)COC4=CC=C(C=C4)N5C=NN=N5
PubChem CID	25025505
Molecular Weight	448.54

PubChem CID

CAS Registry No.

ChEMBL Ligand

BindingDB Ligand

GPCRdb Ligand

RCSB PDB Ligand

Certificates

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2 results found

Lot Number	Certificate Type	Date	Item
L2325085	Certificate of Analysis	Jan 03, 2024	M127623
E1709075	Certificate of Analysis	Dec 09, 2022	M127623

References

1. Alper P, Azimioara M, Cow C, Mutnick D, Nikulin V, Michellys PY, Wang Z, Reding E, Paliotti M, Li J et al.. (2014) Discovery of structurally novel, potent and orally efficacious GPR119 agonists.. Bioorg Med Chem Lett, 24 (10): (2383-7). [PMID:24751443]
2. Spasov AA, Kosolapov VA, Babkov DA, Maika OY. (2017) Effect of GRP119 Receptor Agonist, Compound MBX-2982, on Activity of Human Glucokinase.. Bull Exp Biol Med, 163 (5): (695-698). [PMID:28944428]

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