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ME 0328 - 98%, high purity , CAS No.1445251-22-8, Inhibitor of poly(ADP-ribose) polymerase 1;Inhibitor of poly (ADP-ribose) polymerase 3

Moligand™
≥98%

CAS#: 1445251-22-8
Formula: C₁₉H₁₉N₃O₂
Molecular Weight: 321.37
PubChem CID: 135566764

Item Number

M276516

Grouped product items
SKU	Size	Availability	Price
M276516-5mg	5mg	In stock	$58.90
M276516-10mg	10mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$88.90
M276516-25mg	25mg	In stock	$187.90
M276516-50mg	50mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$335.90
M276516-100mg	100mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$602.90

Cell-permeable, selective PARP-3 inhibitor

View related series

poly (ADP-ribose) polymerase 3 Inhibitor poly(ADP-ribose) polymerase 1 Inhibitor

Basic Description

Synonyms	ME0328\|1445251-22-8\|ME-0328\|3-(4-Oxo-3,4-Dihydroquinazolin-2-Yl)-N-[(1s)-1-Phenylethyl]propanamide\|(S)-3-(4-Oxo-3,4-dihydroquinazolin-2-yl)-N-(1-phenylethyl)propanamide\|3-(4-OXO-3H-QUINAZOLIN-2-YL)-N-[(1S)-1-PHENYLETHYL]PROPANAMIDE\|compound 5b [PMID 24188
Specifications & Purity	98%
Storage Temp	Store at -20°C
Shipped In	Dry ice
Grade	Moligand™
Action Type	INHIBITOR
Mechanism of action	Inhibitor of poly(ADP-ribose) polymerase 1;Inhibitor of poly (ADP-ribose) polymerase 3

Associated Targets

PARP3 Tclin Poly [ADP-ribose] polymerase 3 2 Activities

Discover Target: PARP3

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

PARP1 Tclin Poly [ADP-ribose] polymerase 1 1 Activities

Discover Target: PARP1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

IUPAC Name	3-(4-oxo-3H-quinazolin-2-yl)-N-[(1S)-1-phenylethyl]propanamide
INCHI	InChI=1S/C19H19N3O2/c1-13(14-7-3-2-4-8-14)20-18(23)12-11-17-21-16-10-6-5-9-15(16)19(24)22-17/h2-10,13H,11-12H2,1H3,(H,20,23)(H,21,22,24)/t13-/m0/s1
InChi Key	QIHBWVVVRYYYRO-ZDUSSCGKSA-N
Canonical SMILES	CC(C1=CC=CC=C1)NC(=O)CCC2=NC3=CC=CC=C3C(=O)N2
Isomeric SMILES	C[C@@H](C1=CC=CC=C1)NC(=O)CCC2=NC3=CC=CC=C3C(=O)N2
PubChem CID	135566764
Molecular Weight	321.37

PubChem CID

ChEMBL Ligand

CAS Registry No.

RCSB PDB Ligand

Certificates

Certificate of Analysis(COA)

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2 results found

Lot Number	Certificate Type	Date	Item
L2108733	Certificate of Analysis	Sep 13, 2022	M276516
L2108734	Certificate of Analysis	Sep 13, 2022	M276516

Safety and Hazards(GHS)

Pictogram(s)	GHS07
Signal	Warning
Hazard Statements	H302:Harmful if swallowed
Precautionary Statements	P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P270:Do not eat, drink or smoke when using this product. P330:Rinse mouth. P301+P317:IF SWALLOWED: Get medical help.

References

1. Lindgren AE, Karlberg T, Ekblad T, Spjut S, Thorsell AG, Andersson CD, Nhan TT, Hellsten V, Weigelt J, Linusson A et al.. (2013) Chemical probes to study ADP-ribosylation: synthesis and biochemical evaluation of inhibitors of the human ADP-ribosyltransferase ARTD3/PARP3.. J Med Chem, 56 (23): (9556-68). [PMID:24188023]

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