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Mecamylamine hydrochloride - 98%, high purity , Neuronal acetylcholine receptor; alpha3/beta4 negative allosteric modulator, CAS No.826-39-1, Neuronal acetylcholine receptor; alpha3/beta4 negative allosteric modulator

≥98%

CAS#: 826-39-1
Formula: C₁₁H₂₁N · HCl
Molecular Weight: 203.75
EC Number: 212-555-8
MDL number: MFCD00151462
PubChem CID: 13221
PubChem SID: 488181815

Item Number

M136896

Grouped product items
SKU	Size	Availability	Price
M136896-5mg	5mg	In stock	$38.90
M136896-25mg	25mg	In stock	$147.90
M136896-100mg	100mg	In stock	$532.90

Non-competitive antagonist of nicotinic receptors

Basic Description

Synonyms	MECAMYLAMINE HYDROCHLORIDE\|826-39-1\|Inversine\|Mevasin\|Mekamin hydrochloride\|Vecamyl\|Mecamine hydrochloride\|Mecamylamine HCl\|Mevasine\|Mecamylamine (hydrochloride)\|N,2,3,3-Tetramethylbicyclo[2.2.1]heptan-2-amine hydrochloride\|EINECS 212-555-8\|Mecamylamine,
Specifications & Purity	≥98%
Biochemical and Physiological Mechanisms	Non-competitive nicotine acetylcholine receptor antagonists preferentially block nicotine receptors in the autonomic ganglia and cross the blood-brain barrier.
Shipped In	Normal
Action Type	NEGATIVE ALLOSTERIC MODULATOR
Mechanism of action	Neuronal acetylcholine receptor; alpha3/beta4 negative allosteric modulator
Note	Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Toxic, refer to SDS for further information. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description	Mecamylamine Hydrochloride is a noncompetitive and nonselective antagonist of AChRs. The compound preferentially blocks nicotinic receptors at autonomic ganglia and is able to cross the blood brain barrier. Once across the blood brain barrier Mecamylamine Hydrochloride can selectively antagonize neuronal AChRs. Mecamylamine Hydrochloride is an inhibitor of AChR α 3, AChR α 4, AChR α 7 and AChRβ2. A noncompetitive nicotinic AChR inhibitor.

Associated Targets

SLCO1B1 Tchem Solute carrier organic anion transporter family member 1B1 0 Activities

Discover Target: SLCO1B1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

SLCO1B3 Tchem Solute carrier organic anion transporter family member 1B3 0 Activities

Discover Target: SLCO1B3

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

POLI Tchem DNA polymerase iota 0 Activities

Discover Target: POLI

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

Pubchem Sid	488181815
Pubchem Sid Url	https://pubchem.ncbi.nlm.nih.gov/substance/488181815
IUPAC Name	N,2,3,3-tetramethylbicyclo[2.2.1]heptan-2-amine;hydrochloride
INCHI	InChI=1S/C11H21N.ClH/c1-10(2)8-5-6-9(7-8)11(10,3)12-4;/h8-9,12H,5-7H2,1-4H3;1H
InChi Key	PKVZBNCYEICAQP-UHFFFAOYSA-N
Canonical SMILES	CC1(C2CCC(C2)C1(C)NC)C.Cl
Isomeric SMILES	CC1(C2CCC(C2)C1(C)NC)C.Cl
WGK Germany	3
RTECS	RB6900000
PubChem CID	13221
Molecular Weight	203.75

Certificates

Certificate of Analysis(COA)

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5 results found

Lot Number	Certificate Type	Date	Item
C2330752	Certificate of Analysis	Mar 17, 2023	M136896
C2330753	Certificate of Analysis	Mar 17, 2023	M136896
C2330754	Certificate of Analysis	Mar 17, 2023	M136896
C2330758	Certificate of Analysis	Mar 17, 2023	M136896
C2330779	Certificate of Analysis	Mar 17, 2023	M136896

Safety and Hazards(GHS)

Pictogram(s)	GHS06, GHS07
Signal	Danger
Hazard Statements	H315:Causes skin irritation H319:Causes serious eye irritation H335:May cause respiratory irritation H301:Toxic if swallowed
Precautionary Statements	P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P271:Use only outdoors or in a well-ventilated area. P270:Do not eat, drink or smoke when using this product. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P362+P364:Take off contaminated clothing and wash it before reuse. P330:Rinse mouth. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P301+P316:IF SWALLOWED: Get emergency medical help immediately. P337+P317:If eye irritation persists: Get medical help. P332+P317:If skin irritation occurs: Get medical help. P319:Get medical help if you feel unwell.
WGK Germany	3
RTECS	RB6900000

References

1. Gawel K et al.. (2016) Acquisition and reinstatement of ethanol-induced conditioned place preference in rats: Effects of the cholinesterase inhibitors donepezil and rivastigmine.. J Psychopharmacol, 30 (7): (676-87). [PMID:27097732]
2. Luo R et al.. (2013) Direct and GABA-mediated indirect effects of nicotinic ACh receptor agonists on striatal neurones.. J Physiol, 591 (Pt 1): (203-17). [PMID:23045343]
3. Singh NS et al.. (2013) Nicotinic acetylcholine receptor antagonists alter the function and expression of serine racemase in PC-12 and 1321N1 cells.. Cell Signal, 25 (12): (2634-45). [PMID:24012499]

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