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Meclizine 2HCl - ≥98%, high purity , CAS No.1104-22-9
Human pregnane X receptor agonist; H1antagonist
Basic Description Synonyms Meclizine dihydrochloride|1104-22-9|Meclizine hydrochloride|Meclozine dihydrochloride|Bonamine|1-((4-Chlorophenyl)(phenyl)methyl)-4-(3-methylbenzyl)piperazine dihydrochloride|Ancolan dihydrochloride|Meclizine 2HCl|Diadril|Vertizine|Taizer|V-Cline|Meclizin Specifications & Purity ≥98% Biochemical and Physiological Mechanisms Human pregnane X receptor (hPXR) agonist; stronger activator of hPXR than rat PXR. Increases hPXR target gene expression in human hepatocyte primary cultures. Also acts as a histamine H1receptor antagonist. Confers neuroprotection in models of polyQ toxic Storage Temp Store at 2-8°C Shipped In Wet ice Note 25g卖完停产，不再备货 Product Description Meclizine is a histamine H1 receptor antagonist used to treat nausea and motion sickness, has anti-histamine, anti-muscarinic and anti-oxidative phosphorylation properties, also an agonist ligand for mCAR (constitutive androstane receptor) and an inverse agonist for hCAR.
Names and Identifiers IUPAC Name 1-[(4-chlorophenyl)-phenylmethyl]-4-[(3-methylphenyl)methyl]piperazine;dihydrochloride INCHI InChI=1S/C25H27ClN2.2ClH/c1-20-6-5-7-21(18-20)19-27-14-16-28(17-15-27)25(22-8-3-2-4-9-22)23-10-12-24(26)13-11-23;;/h2-13,18,25H,14-17,19H2,1H3;2*1H InChi Key VCTHNOIYJIXQLV-UHFFFAOYSA-N Canonical SMILES CC1=CC(=CC=C1)CN2CCN(CC2)C(C3=CC=CC=C3)C4=CC=C(C=C4)Cl.Cl.Cl Isomeric SMILES CC1=CC(=CC=C1)CN2CCN(CC2)C(C3=CC=CC=C3)C4=CC=C(C=C4)Cl.Cl.Cl WGK Germany 3 RTECS TL2005000 PubChem CID 64713 Molecular Weight 463.87
Chemical and Physical Properties Solubility Solvent:DMSO, Max Conc. mg/mL: 23.19, Max Conc. mM: 50 Sensitivity Heat Sensitive Melt Point(°C) 210-213°C
Safety and Hazards(GHS) Pictogram(s) GHS08 , GHS07 Signal Warning Hazard Statements H302: Harmful if swallowed
H361: Suspected of damaging fertility or the unborn child
Precautionary Statements P280: Wear protective gloves/protective clothing/eye protection/face protection.
P405: Store locked up.
P501: Dispose of contents/container to ...
P264: Wash hands [and …] thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P330: Rinse mouth.
P203: Obtain, read and follow all safety instructions before use.
P301+P317: IF SWALLOWED: Get medical help.
P318: if exposed or concerned, get medical advice.
WGK Germany 3 RTECS TL2005000
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