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MEDI-3617 (anti-ANGPT2) - Primary antibody, specific to ANGPT2, Human IgG2, INHIBITOR of Angiopoietin-2 inhibitor

  • Azide Free
  • Carrier Free
  • ExactAb™
  • Low Endotoxin
  • RValidatedant
  • Validated
  • ≥95%(SDS-PAGE&SEC)
  • Lot by Lot
Features and benefits
  • Short Overview:

    Purity≥95% (SDS-PAGE&SEC); Endotoxin Level≤1.0EU/mg; Human IgG2SA; CHO; ELISA, FACS, Functional assay, Animal Model; Unconjugated

  • Species reactivity(Reacts with): Human
  • Isotype: Human IgG2SA
    Application:
  • Animal Model
  • ELISA
  • Flow Cytometry
  • Functional Assay
Item Number
Ab183134
Grouped product items
SKUSizeAvailabilityPrice Qty
Ab183134-100μg
100μg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$109.90
Ab183134-1mg
1mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$519.90
Ab183134-5mg
5mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$1,399.90
Ab183134-10mg
10mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$2,239.90

Purity≥95% (SDS-PAGE&SEC); Endotoxin Level≤1.0EU/mg; Human IgG2SA; CHO; ELISA, FACS, Functional assay, Animal Model; Unconjugated

Basic Description

Product NameMEDI-3617 (anti-ANGPT2) - Primary antibody, specific to ANGPT2, Human IgG2
Specifications & PurityCarrier Free, Low Endotoxin, Azide Free, Validated, RValidatedant, ExactAb™, ≥95%(SDS-PAGE&SEC), Lot by Lot
SpecificityANGPT2
ConjugationUnconjugated
GradeAzide Free, Carrier Free, ExactAb™, Low Endotoxin, RValidatedant, Validated
Action TypeINHIBITOR
Mechanism of actionINHIBITOR of Angiopoietin-2 inhibitor
Product Description

MEDI-3617 (anti-ANGPT2) is a human monoclonal antibody directed against the angiogenic cytokines angiopoietin-2 (Angpt2). MEDI-3617 (anti-ANGPT2) in combination with tremelimumab is used to treat advanced melanoma.
Purity
≥95% (SDS-PAGE&SEC)
Endotoxin Level
≤1.0EU/mg
Protein Function
Can induce tyrosine phosphorylation of TIE2. Binds to TIE2 receptor and counteracts blood vessel maturation/stability mediated by angiopoietin-1. Its function may be context-dependent. In the absence of angiogenic inducers, such as VEGF, ANG2-mediated loosening of cell-matrix contacts may induce endothelial cell apoptosis with consequent vascular regression. In concert with VEGF, it may facilitate endothelial cell migration and proliferation, thus serving as a permissive angiogenic signal.

Product Properties

IsotypeHuman IgG2SA
Light Chain Typekappa
Purification MethodProtein A purified
FormLiquid
ConcentrationLot by Lot
Storage TempStore at -80°C,Avoid repeated freezing and thawing
Shipped InIce chest + Ice pads
Stability And StorageStore at -80℃ for 24 months. Upon delivery aliquot. Avoid freeze/thaw cycle.

Images

MEDI-3617 (anti-ANGPT2) (Ab183134) - ELISA
Immobilized human ANGPT2-chis at 2.0 μg/mL can bind MEDI-3617 (anti-ANGPT2) (Ab183134) with the EC50 of 31.65 ng/mL.

MEDI-3617 (anti-ANGPT2) (Ab183134) - SEC
The purity of MEDI-3617 (anti-ANGPT2) (Ab183134) is more than 95% verified by HPLC.

Associated Targets

ANGPT2 Tclin Angiopoietin-2 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

Certificates

Certificate of Analysis(COA)

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Related Documents

Solution Calculators