melphalan flufenamide , CAS No.380449-51-4

Item Number

M611785

Grouped product items
SKU	Size	Availability	Price	Qty
M611785-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,300.90
M611785-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$2,000.90

Basic Description

Synonyms	Melphalan flufenamide \| Melflufen \| Prodrug J-1 \| Prodrug J 1 \| J-1 (prodrug) \| 380449-51-4 \| J 1 (prodrug) \| UNII-F70C5K4786 \| F70C5K4786 \| Melphalan flufenamide [USAN:INN] \| WHO 9493 \| 380449-51-4 (free base) \| J-1 \| L-Phenylalanine, 4-(bis(2-chloroethyl)amino)-l-phenylalanyl-4-
Specifications & Purity	Moligand™
Grade	Moligand™

Names and Identifiers

IUPAC Name	ethyl (2S)-2-[[(2S)-2-amino-3-[4-[bis(2-chloroethyl)amino]phenyl]propanoyl]amino]-3-(4-fluorophenyl)propanoate
INCHI	InChI=1S/C24H30Cl2FN3O3/c1-2-33-24(32)22(16-18-3-7-19(27)8-4-18)29-23(31)21(28)15-17-5-9-20(10-6-17)30(13-11-25)14-12-26/h3-10,21-22H,2,11-16,28H2,1H3,(H,29,31)/t21-,22-/m0/s1
InChi Key	YQZNKYXGZSVEHI-VXKWHMMOSA-N
Canonical SMILES	ClCCN(c1ccc(cc1)C[C@@H](C(=O)N[C@H](C(=O)OCC)Cc1ccc(cc1)F)N)CCCl
Isomeric SMILES	CCOC(=O)[C@H](CC1=CC=C(C=C1)F)NC(=O)[C@H](CC2=CC=C(C=C2)N(CCCl)CCCl)N
PubChem CID	9935639

PubChem CID

CAS Registry No.

ChEMBL Ligand

References

1. Delforoush M, Strese S, Wickström M, Larsson R, Enblad G, Gullbo J. (2016) In vitro and in vivo activity of melflufen (J1)in lymphoma.. BMC Cancer, 16 (3): (263). [PMID:27044263]
2. Oriol A, Larocca A, Leleu X, Hajek R, Hassoun H, Rodríguez-Otero P, Paner A, Schjesvold FH, Gullbo J, Richardson PG. (2020) Melflufen for relapsed and refractory multiple myeloma.. Expert Opin Investig Drugs, 29 (10): (1069-1078). [PMID:32924646]
3. Richardson PG, Oriol A, Larocca A, Bladé J, Cavo M, Rodriguez-Otero P, Leleu X, Nadeem O, Hiemenz JW, Hassoun H et al.. (2021) Melflufen and Dexamethasone in Heavily Pretreated Relapsed and Refractory Multiple Myeloma.. J Clin Oncol, 39 (7): (757-767). [PMID:33296242]
4. Dhillon S. (2021) Melphalan Flufenamide (Melflufen): First Approval.. Drugs, 81 (8): (963-969). [PMID:33961277]
5. Byrgazov K, Besse A, Kraus M, Slipicevic A, Lehmann F, Driessen C, Besse L. (2021) Novel Peptide-drug Conjugate Melflufen Efficiently Eradicates Bortezomib-resistant Multiple Myeloma Cells Including Tumor-initiating Myeloma Progenitor Cells.. Hemasphere, 5 (7): (e602). [PMID:34136753]

Solution Calculators

Determine the necessary mass, volume, or concentration for preparing a solution.

Determine the dilution needed to prepare a stock solution.

Basic Description