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M423151-1ml

1ml

Available within 4-8 weeks(?)

$27.90

Basic Description

Synonyms	Succimer \| meso-2,3-Dimercaptosuccinic acid \| 304-55-2 \| Dim-sa \| meso-Dimercaptosuccinic acid \| DMSA \| Chemet \| (2R,3S)-rel-2,3-Dimercaptosuccinic acid \| Succimero \| Succimerum \| Butanedioic acid, 2,3-dimercapto-, (2R,3S)-rel- \| DMS-A \| Ro 1-7977 \| Dimercaptosuccinic acid \| (R,S)
Specifications & Purity	10mM in DMSO
Biochemical and Physiological Mechanisms	Lead chelating agent and ROS° scavenger. Hypotensive effect in vitro . Reduces oxidative stress and apoptosis in vivo . Orally active. Active in vivo and in vitro .
Storage Temp	Store at -80°C
Shipped In	Ice chest + Ice pads
Product Description	DMSA (Meso-2,3-dimercaptosuccinic acid) is a potent lead chelating agent found to be a scavenger of reactive oxygen species (ROS). Murine experiments have shown that this compound also lowers blood pressure in rat arterial hypertension via a decrease in total cell calcium levels. It has also been observed that DMSA upregulates mRNA expression of macrophage-1 antigen, L-, E-, and P-selectin, as well as causing an increase in TNFα (tumor necrosis factor-α) concentrations in murine lung. Mechanistic studies suggest that DMSA is metabolized into mixed disulfides of cysteine, which are active chelating agents. A water-soluble chelating agent.

Product Properties

ALogP	0.1

Associated Targets(Human)

F2 Tclin Thrombin (11687 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

ESR1 Tclin Estrogen receptor alpha (17718 Activities)

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PGR Tclin Progesterone receptor (8562 Activities)

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CHRM2 Tclin Muscarinic acetylcholine receptor M2 (10671 Activities)

Discover Target: CHRM2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

HTR1A Tclin Serotonin 1a (5-HT1a) receptor (14969 Activities)

Discover Target: HTR1A

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

ADRA2A Tclin Alpha-2a adrenergic receptor (9450 Activities)

Discover Target: ADRA2A

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

AR Tclin Androgen Receptor (11781 Activities)

Discover Target: AR

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

CHRM1 Tclin Muscarinic acetylcholine receptor M1 (12690 Activities)

Discover Target: CHRM1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

GABRA1 Tclin GABA receptor alpha-1 subunit (399 Activities)

Discover Target: GABRA1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

MAOA Tclin Monoamine oxidase A (11911 Activities)

Discover Target: MAOA

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

DRD1 Tclin Dopamine D1 receptor (9720 Activities)

Discover Target: DRD1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

ACHE Tclin Acetylcholinesterase (18204 Activities)

Discover Target: ACHE

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

PTGS1 Tclin Cyclooxygenase-1 (9233 Activities)

Discover Target: PTGS1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

SLC6A2 Tclin Norepinephrine transporter (10102 Activities)

Discover Target: SLC6A2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

ADORA1 Tclin Adenosine A1 receptor (17603 Activities)

Discover Target: ADORA1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

SLC6A4 Tclin Serotonin transporter (12625 Activities)

Discover Target: SLC6A4

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ADRA1A Tclin Alpha-1a adrenergic receptor (8359 Activities)

Discover Target: ADRA1A

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

OPRM1 Tclin Mu opioid receptor (19785 Activities)

Discover Target: OPRM1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

DRD3 Tclin Dopamine D3 receptor (14368 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

SLC6A3 Tclin Dopamine transporter (10535 Activities)

Discover Target: SLC6A3

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

KCNH2 Tclin HERG (29587 Activities)

Discover Target: KCNH2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

PDE3A Tclin Phosphodiesterase 3A (3309 Activities)

Discover Target: PDE3A

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

HTR2B Tclin Serotonin 2b (5-HT2b) receptor (10323 Activities)

Discover Target: HTR2B

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

TBXA2R Tclin Thromboxane A2 receptor (5717 Activities)

Discover Target: TBXA2R

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

PDE4A Tclin Phosphodiesterase 4A (1943 Activities)

Discover Target: PDE4A

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

HRH3 Tclin Histamine H3 receptor (10389 Activities)

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Homo sapiens (32628 Activities)

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ABCB11 Tchem Bile salt export pump (2311 Activities)

Discover Target: ABCB11

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Associated Targets(non-human)

Hdac6 Histone deacetylase 6 (222 Activities)

Discover Target: Hdac6

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

rep Replicase polyprotein 1ab (378 Activities)

Discover Target: rep

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

groL GroEL/GroES (1042 Activities)

Discover Target: groL

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

SARS-CoV-2 (38078 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Names and Identifiers

IUPAC Name	(2S,3R)-2,3-bis(sulfanyl)butanedioic acid
INCHI	InChI=1S/C4H6O4S2/c5-3(6)1(9)2(10)4(7)8/h1-2,9-10H,(H,5,6)(H,7,8)/t1-,2+
InChi Key	ACTRVOBWPAIOHC-XIXRPRMCSA-N
Canonical SMILES	C(C(C(=O)O)S)(C(=O)O)S
Isomeric SMILES	[C@@H]([C@@H](C(=O)O)S)(C(=O)O)S
WGK Germany	2
RTECS	WM7650000
PubChem CID	2724354
Molecular Weight	182.22
Beilstein	1725150
Reaxy-Rn	1725150

Certificates

Certificate of Analysis(COA)

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Chemical and Physical Properties

Sensitivity	air sensitive
Melt Point(°C)	196-198°C

Safety and Hazards(GHS)

Pictogram(s)	GHS08, GHS07
Signal	Warning
Hazard Statements	H315:Causes skin irritation H319:Causes serious eye irritation H335:May cause respiratory irritation H361:Suspected of damaging fertility or the unborn child
Precautionary Statements	P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P271:Use only outdoors or in a well-ventilated area. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P362+P364:Take off contaminated clothing and wash it before reuse. P203:Obtain, read and follow all safety instructions before use. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P318:if exposed or concerned, get medical advice. P337+P317:If eye irritation persists: Get medical help. P332+P317:If skin irritation occurs: Get medical help. P319:Get medical help if you feel unwell.
WGK Germany	2
RTECS	WM7650000
Reaxy-Rn	1725150

Citations of This Product

1. Zhuhui Chen, Yue Xiong, Ranran Ma, Pei Chen, Le Duan, Shuying Yang, Ineza Urujeni Gisèle, Linjun You, Deli Xiao. (2023) A novel magnetic fluid for ultra-fast and highly efficient extraction of N1-methylnicotinamide in urine samples. NEW JOURNAL OF CHEMISTRY, 47 (16): (7862-7872). [PMID:]
2. Yanjun Huang, Qingdi Kong, Xiaojie Zhang, Hong Peng. (2022) DMSA-incorporated silsesquioxane-based hybrid polymer for selective adsorption of Pb(II) from wastewater. JOURNAL OF MOLECULAR LIQUIDS, 368 (120723). [PMID:]
3. Min Chen, Jun Wang, Qianbo Zhang, Jinsheng Zhang, Zhiming Chen, Rongguo Sun. (2023) Reversible detection of Hg(II) in pure water based on thymine modified nitrogen, sulfur co-doped carbon dots combined with antidote. SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY, 286 (121998). [PMID:36279800]
4. Zhongyuan Chen, Yueting Peng, Yichao Li, Xiaoxue Xie, Xiaodan Wei, Geng Yang, Hanxi Zhang, Ningxi Li, Tingting Li, Xiang Qin, Shun Li, Chunhui Wu, Fengming You, Hong Yang, Yiyao Liu. (2021) Aptamer-Dendrimer Functionalized Magnetic Nano-Octahedrons: Theranostic Drug/Gene Delivery Platform for Near-Infrared/Magnetic Resonance Imaging-Guided Magnetochemotherapy. ACS Nano, 15 (10): (16683–16696). [PMID:34586789]
5. Zhongyuan Chen,Yueting Peng,Xiaoxue Xie,Yi Feng,Tingting Li,Shun Li,Xiang Qin,Hong Yang,Chunhui Wu,Chuan Zheng,Jie Zhu,Fengming You,Yiyao Liu. (2019-09-20) Dendrimer-Functionalized Superparamagnetic Nanobeacons for Real-Time Detection and Depletion of HSP90α mRNA and MR Imaging.. Theranostics, 9 ((20)): (5784-5796). [PMID:31534519]

References

1. Zhuhui Chen, Yue Xiong, Ranran Ma, Pei Chen, Le Duan, Shuying Yang, Ineza Urujeni Gisèle, Linjun You, Deli Xiao. (2023) A novel magnetic fluid for ultra-fast and highly efficient extraction of N1-methylnicotinamide in urine samples. NEW JOURNAL OF CHEMISTRY, 47 (16): (7862-7872). [PMID:]
2. Yanjun Huang, Qingdi Kong, Xiaojie Zhang, Hong Peng. (2022) DMSA-incorporated silsesquioxane-based hybrid polymer for selective adsorption of Pb(II) from wastewater. JOURNAL OF MOLECULAR LIQUIDS, 368 (120723). [PMID:]
3. Min Chen, Jun Wang, Qianbo Zhang, Jinsheng Zhang, Zhiming Chen, Rongguo Sun. (2023) Reversible detection of Hg(II) in pure water based on thymine modified nitrogen, sulfur co-doped carbon dots combined with antidote. SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY, 286 (121998). [PMID:36279800]
4. Zhongyuan Chen, Yueting Peng, Yichao Li, Xiaoxue Xie, Xiaodan Wei, Geng Yang, Hanxi Zhang, Ningxi Li, Tingting Li, Xiang Qin, Shun Li, Chunhui Wu, Fengming You, Hong Yang, Yiyao Liu. (2021) Aptamer-Dendrimer Functionalized Magnetic Nano-Octahedrons: Theranostic Drug/Gene Delivery Platform for Near-Infrared/Magnetic Resonance Imaging-Guided Magnetochemotherapy. ACS Nano, 15 (10): (16683–16696). [PMID:34586789]
5. Zhongyuan Chen,Yueting Peng,Xiaoxue Xie,Yi Feng,Tingting Li,Shun Li,Xiang Qin,Hong Yang,Chunhui Wu,Chuan Zheng,Jie Zhu,Fengming You,Yiyao Liu. (2019-09-20) Dendrimer-Functionalized Superparamagnetic Nanobeacons for Real-Time Detection and Depletion of HSP90α mRNA and MR Imaging.. Theranostics, 9 ((20)): (5784-5796). [PMID:31534519]

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meso-2,3-Dimercaptosuccinic acid - 10mM in DMSO, high purity