Lead chelating agent and ROS° scavenger. Hypotensive effect in vitro . Reduces oxidative stress and apoptosis in vivo . Orally active. Active in vivo and in vitro .
Storage Temp
Store at -80°C
Shipped In
Ice chest + Ice pads
Product Description
DMSA (Meso-2,3-dimercaptosuccinic acid) is a potent lead chelating agent found to be a scavenger of reactive oxygen species (ROS). Murine experiments have shown that this compound also lowers blood pressure in rat arterial hypertension via a decrease in total cell calcium levels. It has also been observed that DMSA upregulates mRNA expression of macrophage-1 antigen, L-, E-, and P-selectin, as well as causing an increase in TNFα (tumor necrosis factor-α) concentrations in murine lung. Mechanistic studies suggest that DMSA is metabolized into mixed disulfides of cysteine, which are active chelating agents. A water-soluble chelating agent.
1.Zhuhui Chen, Yue Xiong, Ranran Ma, Pei Chen, Le Duan, Shuying Yang, Ineza Urujeni Gisèle, Linjun You, Deli Xiao. (2023) A novel magnetic fluid for ultra-fast and highly efficient extraction of N1-methylnicotinamide in urine samples. NEW JOURNAL OF CHEMISTRY, 47 (16):(7862-7872). [PMID:]
2.Yanjun Huang, Qingdi Kong, Xiaojie Zhang, Hong Peng. (2022) DMSA-incorporated silsesquioxane-based hybrid polymer for selective adsorption of Pb(II) from wastewater. JOURNAL OF MOLECULAR LIQUIDS, 368 (120723). [PMID:]
3.Min Chen, Jun Wang, Qianbo Zhang, Jinsheng Zhang, Zhiming Chen, Rongguo Sun. (2023) Reversible detection of Hg(II) in pure water based on thymine modified nitrogen, sulfur co-doped carbon dots combined with antidote. SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY, 286 (121998). [PMID:36279800]
5.Zhongyuan Chen,Yueting Peng,Xiaoxue Xie,Yi Feng,Tingting Li,Shun Li,Xiang Qin,Hong Yang,Chunhui Wu,Chuan Zheng,Jie Zhu,Fengming You,Yiyao Liu. (2019-09-20) Dendrimer-Functionalized Superparamagnetic Nanobeacons for Real-Time Detection and Depletion of HSP90α mRNA and MR Imaging.. Theranostics, 9 ((20)):(5784-5796). [PMID:31534519]
References
1.Zhuhui Chen, Yue Xiong, Ranran Ma, Pei Chen, Le Duan, Shuying Yang, Ineza Urujeni Gisèle, Linjun You, Deli Xiao. (2023) A novel magnetic fluid for ultra-fast and highly efficient extraction of N1-methylnicotinamide in urine samples. NEW JOURNAL OF CHEMISTRY, 47 (16):(7862-7872). [PMID:]
2.Yanjun Huang, Qingdi Kong, Xiaojie Zhang, Hong Peng. (2022) DMSA-incorporated silsesquioxane-based hybrid polymer for selective adsorption of Pb(II) from wastewater. JOURNAL OF MOLECULAR LIQUIDS, 368 (120723). [PMID:]
3.Min Chen, Jun Wang, Qianbo Zhang, Jinsheng Zhang, Zhiming Chen, Rongguo Sun. (2023) Reversible detection of Hg(II) in pure water based on thymine modified nitrogen, sulfur co-doped carbon dots combined with antidote. SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY, 286 (121998). [PMID:36279800]
