Methyl-β-cyclodextrin (MβCD) is a macrocyclic compound that can form inclusion complexes with a number of guest molecules. It shows higher solubility in aqueous solutions and greater solubilizing and complexing power compared to the parent β-cyclodextrin. MβCD can be used to enhance the enzyme activity and enantioselectivity of subtilizing enzyme in organic solvents.
Application: Methyl-β-cyclodextrin is a cholesterol-removing agent mainly used for lipid raft disruption.[4] It may also be used for detergent removal from protein-lipid-detergent ternary mixture to produce 2D membrane protein crystals due to its high solubility and affinity for detergents generally used in membrane protein chemistry. Methyl-β-cyclodextrin may be used as: A buffer additive for the effective separation of aminophospholipids by modified micellar electrokinetic capillary chromatography (MEKC) coupled with laser-induced fluorescence detection. A mobile phase additive for the analysis of R,S-naproxen mixtures in commercial tablet formulations by conventional and nano-liquid chromatography (nano-LC). An analytical standard for the determination of the analyte in biological samples by high performance liquid chromatography (HPLC). A chiral selector for the resolution of repaglinide enantiomers in pharmaceutical formulations by capillary electrophoresis.
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