Grouped product items

SKU

Size

Availability

Price

Qty

M102717-1g

In stock

$9.90

M102717-5g

In stock

$15.90

M102717-25g

25g

In stock

$20.90

M102717-100g

100g

In stock

$42.90

M102717-500g

500g

Available within 4-8 weeks(?)

$189.90

Basic Description

Synonyms	Methylene Blue trihydrate\|7220-79-3\|Methylthionine chloride\|C.I. Basic Blue 9 trihydrate\|Phenothiazin-5-ium, 3,7-bis(dimethylamino)-, chloride, trihydrate\|Basic Blue 9 trihydrate\|3,7-Bis(dimethylamino)phenothiazin-5-ium chloride trihydrate\|7220-79-3 (hdyr
Specifications & Purity	Purifed, Biological stain, ≥90%(HPLC)
Shipped In	Normal
Grade	Purifed, 生物染色剂
Product Description	Methylene Blue acts as a GCS (guanylyl cyclase) inhibitor, biological stain and redox indicator. Methylene Blue inhibits tau filament formation. Additionally, Methylene Blue is also reported to inhibit NOSs (nitric oxide synthase). Methylene Blue is widely used to inhibit cGMP-mediated processes. Methylene Blue has been observed to dose-dependently induce cytotoxicity in U-373 MG human astrocytoma and SK-N-MC human neuroblastoma cells. Furthermore Methylene Blue is reported to bind to the M2 subtype of muscarinic receptors in rat cardiac myocytes, and thus exhibit antimuscarinic effects on IK, ACh and ICa. Methylene Blue has also been reported to inhibit endothelium-dependent relaxation of isolated blood vessels. An inhibitor of cGMP-mediated processes and guanylyl cyclase, a useful stain, and a redox indicator

Associated Targets

CYP3A4 Tclin Cytochrome P450 3A4 0 Activities

Discover Target: CYP3A4

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

ESR1 Tclin Estrogen receptor 0 Activities

Discover Target: ESR1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

NR3C1 Tclin Glucocorticoid receptor 0 Activities

Discover Target: NR3C1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

HSPD1 Tbio 60 kDa heat shock protein, mitochondrial 0 Activities

Discover Target: HSPD1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

RUNX1 Tbio Runt-related transcription factor 1 0 Activities

Discover Target: RUNX1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

RORC Tchem Nuclear receptor ROR-gamma 0 Activities

Discover Target: RORC

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

HIF1A Tchem Hypoxia-inducible factor 1-alpha 0 Activities

Discover Target: HIF1A

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

HSD17B10 Tchem 3-hydroxyacyl-CoA dehydrogenase type-2 0 Activities

Discover Target: HSD17B10

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

TNF Tclin Tumor necrosis factor 0 Activities

Discover Target: TNF

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

SMN1 Tchem Survival motor neuron protein 0 Activities

Discover Target: SMN1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

TST Tchem Thiosulfate sulfurtransferase 0 Activities

Discover Target: TST

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

HPGD Tchem 15-hydroxyprostaglandin dehydrogenase [NAD(+)] 0 Activities

Discover Target: HPGD

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

RECQL Tbio ATP-dependent DNA helicase Q1 0 Activities

Discover Target: RECQL

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

ALOX15 Tchem Arachidonate 15-lipoxygenase 0 Activities

Discover Target: ALOX15

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

NR1H4 Tclin Bile acid receptor 0 Activities

Discover Target: NR1H4

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

NR1I2 Tchem Nuclear receptor subfamily 1 group I member 2 0 Activities

Discover Target: NR1I2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

TDP1 Tchem Tyrosyl-DNA phosphodiesterase 1 0 Activities

Discover Target: TDP1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

APEX1 Tchem DNA-(apurinic or apyrimidinic site) lyase 0 Activities

Discover Target: APEX1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

ALDH1A1 Tchem Retinal dehydrogenase 1 0 Activities

Discover Target: ALDH1A1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

THRB Tclin Thyroid hormone receptor beta 0 Activities

Discover Target: THRB

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

TP53 Tchem Cellular tumor antigen p53 0 Activities

Discover Target: TP53

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

PPARD Tchem Peroxisome proliferator-activated receptor delta 0 Activities

Discover Target: PPARD

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

PPARG Tclin Peroxisome proliferator-activated receptor gamma 0 Activities

Discover Target: PPARG

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

NFE2L2 Tchem Nuclear factor erythroid 2-related factor 2 0 Activities

Discover Target: NFE2L2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CXCL8 Tchem Interleukin-8 0 Activities

Discover Target: CXCL8

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

MAPK1 Tchem Mitogen-activated protein kinase 1 0 Activities

Discover Target: MAPK1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

Pubchem Sid	488187373
Pubchem Sid Url	https://pubchem.ncbi.nlm.nih.gov/substance/488187373
IUPAC Name	[7-(dimethylamino)phenothiazin-3-ylidene]-dimethylazanium;chloride;trihydrate
INCHI	InChI=1S/C16H18N3S.ClH.3H2O/c1-18(2)11-5-7-13-15(9-11)20-16-10-12(19(3)4)6-8-14(16)17-13;;;;/h5-10H,1-4H3;1H;3*1H2/q+1;;;;/p-1
InChi Key	XQAXGZLFSSPBMK-UHFFFAOYSA-M
Canonical SMILES	CN(C)C1=CC2=C(C=C1)N=C3C=CC(=[N+](C)C)C=C3S2.O.O.O.[Cl-]
Isomeric SMILES	CN(C)C1=CC2=C(C=C1)N=C3C=CC(=[N+](C)C)C=C3S2.O.O.O.[Cl-]
WGK Germany	2
PubChem CID	104827
Molecular Weight	373.9
Beilstein	3599847

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

To view the certificate results,please click on a Lot number.For Lot numbers from past orders,please use our order status section

13 results found

Lot Number	Certificate Type	Date	Item
G2110313	Certificate of Analysis	Apr 07, 2024	M102717
C2112287	Certificate of Analysis	Dec 15, 2023	M102717
C2112288	Certificate of Analysis	Dec 15, 2023	M102717
D23211055	Certificate of Analysis	Feb 03, 2023	M102717
D23211056	Certificate of Analysis	Feb 03, 2023	M102717
D23211117	Certificate of Analysis	Feb 03, 2023	M102717
D23211335	Certificate of Analysis	Feb 03, 2023	M102717
D23211413	Certificate of Analysis	Feb 03, 2023	M102717
D23211398	Certificate of Analysis	Jan 09, 2023	M102717
I2224445	Certificate of Analysis	Jul 01, 2022	M102717
I2224446	Certificate of Analysis	Jul 01, 2022	M102717
I2224447	Certificate of Analysis	Jul 01, 2022	M102717
I2224448	Certificate of Analysis	Jul 01, 2022	M102717

Chemical and Physical Properties

Solubility	Soluble in water (50 mg/ml), ethanol (70 mg/ml), alcohol, and chloroform. Insoluble in ether.
Melt Point(°C)	235°C

Safety and Hazards(GHS)

Pictogram(s)	GHS08, GHS07
Signal	Warning
Hazard Statements	H315:Causes skin irritation H319:Causes serious eye irritation H335:May cause respiratory irritation H373:Causes damage to organs through prolonged or repeated exposure H302:Harmful if swallowed
Precautionary Statements	P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P260:Do not breathe dust/fume/gas/mist/vapors/spray. P271:Use only outdoors or in a well-ventilated area. P270:Do not eat, drink or smoke when using this product. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P362+P364:Take off contaminated clothing and wash it before reuse. P330:Rinse mouth. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P301+P317:IF SWALLOWED: Get medical help. P337+P317:If eye irritation persists: Get medical help. P332+P317:If skin irritation occurs: Get medical help. P319:Get medical help if you feel unwell.
WGK Germany	2

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Methylene blue - Pure,for Biological Stain,≥90.0% (HPLC), high purity , CAS No.7220-79-3

Basic Description

Associated Targets

CYP3A4 Tclin Cytochrome P450 3A4 0 Activities

ESR1 Tclin Estrogen receptor 0 Activities

NR3C1 Tclin Glucocorticoid receptor 0 Activities

HSPD1 Tbio 60 kDa heat shock protein, mitochondrial 0 Activities

RUNX1 Tbio Runt-related transcription factor 1 0 Activities

RORC Tchem Nuclear receptor ROR-gamma 0 Activities

HIF1A Tchem Hypoxia-inducible factor 1-alpha 0 Activities

HSD17B10 Tchem 3-hydroxyacyl-CoA dehydrogenase type-2 0 Activities

TNF Tclin Tumor necrosis factor 0 Activities

SMN1 Tchem Survival motor neuron protein 0 Activities

TST Tchem Thiosulfate sulfurtransferase 0 Activities

HPGD Tchem 15-hydroxyprostaglandin dehydrogenase [NAD(+)] 0 Activities

RECQL Tbio ATP-dependent DNA helicase Q1 0 Activities

ALOX15 Tchem Arachidonate 15-lipoxygenase 0 Activities

NR1H4 Tclin Bile acid receptor 0 Activities

NR1I2 Tchem Nuclear receptor subfamily 1 group I member 2 0 Activities

TDP1 Tchem Tyrosyl-DNA phosphodiesterase 1 0 Activities

APEX1 Tchem DNA-(apurinic or apyrimidinic site) lyase 0 Activities

ALDH1A1 Tchem Retinal dehydrogenase 1 0 Activities

THRB Tclin Thyroid hormone receptor beta 0 Activities

TP53 Tchem Cellular tumor antigen p53 0 Activities

PPARD Tchem Peroxisome proliferator-activated receptor delta 0 Activities

PPARG Tclin Peroxisome proliferator-activated receptor gamma 0 Activities

NFE2L2 Tchem Nuclear factor erythroid 2-related factor 2 0 Activities

CXCL8 Tchem Interleukin-8 0 Activities

MAPK1 Tchem Mitogen-activated protein kinase 1 0 Activities

Names and Identifiers

Certificates

Certificate of Analysis(COA)

more

Chemical and Physical Properties

Safety and Hazards(GHS)

Related Documents

Alternative Products

Solution Calculators

Molarity Calculator

Dilution Calculator

Reconstitution Calculator