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Metolazone - 98%, high purity , Thiazide-sensitive sodium-chloride cotransporter inhibitor, CAS No.17560-51-9, Thiazide-sensitive sodium-chloride cotransporter inhibitor
Potent peripheral-type benzodiazepine receptor inhibitor
Basic Description Synonyms metolazone|17560-51-9|Zaroxolyn|Mykrox|Diulo|Oldren|Metenix|Metalozone|Microx|Metolazona|Metolazonum|metozalone|Xuret|7-Chloro-2-methyl-4-oxo-3-(o-tolyl)-1,2,3,4-tetrahydroquinazoline-6-sulfonamide|Metolazonum [INN-Latin]|Metolazona [INN-Spanish]|SR-720-2 Specifications & Purity Moligand™, ≥98% Biochemical and Physiological Mechanisms Potent peripheral-type benzodiazepine receptor (PBR) inhibitor (IC 50 = 1 μM). Sodium and phosphate transport inhibitor in proximal tubule. Diuretic and antihypertensive agent. Active in vivo and in vitro Storage Temp Store at -20°C,Desiccated Shipped In Ice chest + Ice pads Grade Moligand™ Action Type INHIBITOR Mechanism of action Thiazide-sensitive sodium-chloride cotransporter inhibitor Note Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details. Product Description Product Describtion:
Metolazone (SR-720-22) is primarily used to treat congestive heart failure and high blood pressure.
Names and Identifiers IUPAC Name 7-chloro-2-methyl-3-(2-methylphenyl)-4-oxo-1,2-dihydroquinazoline-6-sulfonamide INCHI InChI=1S/C16H16ClN3O3S/c1-9-5-3-4-6-14(9)20-10(2)19-13-8-12(17)15(24(18,22)23)7-11(13)16(20)21/h3-8,10,19H,1-2H3,(H2,18,22,23) InChi Key AQCHWTWZEMGIFD-UHFFFAOYSA-N Canonical SMILES CC1NC2=CC(=C(C=C2C(=O)N1C3=CC=CC=C3C)S(=O)(=O)N)Cl Isomeric SMILES CC1NC2=CC(=C(C=C2C(=O)N1C3=CC=CC=C3C)S(=O)(=O)N)Cl PubChem CID 4170 Molecular Weight 365.83
Chemical and Physical Properties Solubility Soluble in DMSO to 100 mM and in ethanol to 10 mM
Safety and Hazards(GHS) Pictogram(s) GHS07 Signal Warning Hazard Statements H315: Causes skin irritation
H319: Causes serious eye irritation
H335: May cause respiratory irritation
Precautionary Statements P261: Avoid breathing dust/fume/gas/mist/vapors/spray.
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352: IF ON SKIN: wash with plenty of water.
P321: Specific treatment (see ... on this label).
P405: Store locked up.
P501: Dispose of contents/container to ...
P264: Wash hands [and …] thoroughly after handling.
P271: Use only outdoors or in a well-ventilated area.
P304+P340: IF INHALED: Remove person to fresh air and keep comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P362+P364: Take off contaminated clothing and wash it before reuse.
P264+P265: Wash hands [and …] thoroughly after handling. Do not touch eyes.
P337+P317: If eye irritation persists: Get medical help.
P332+P317: If skin irritation occurs: Get medical help.
P319: Get medical help if you feel unwell.
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