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Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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SKU | Size | Availability | Price | Qty |
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M275487-1mg | 1mg | In stock | $119.90 | |
M275487-5mg | 5mg | In stock | $266.90 | |
M275487-10mg | 10mg | In stock | $424.90 | |
M275487-25mg | 25mg | In stock | $956.90 | |
M275487-50mg | 50mg | In stock | $1,721.90 | |
M275487-100mg | 100mg | In stock | $3,098.90 |
Potent, reversible proteasome inhibitor
Synonyms | MG-115 | Z-LL-Nva-CHO | 133407-86-0 | MG115 | benzyl N-[(2S)-4-methyl-1-[[(2S)-4-methyl-1-oxo-1-[[(2S)-1-oxopentan-2-yl]amino]pentan-2-yl]amino]-1-oxopentan-2-yl]carbamate | Cbz-Leu-Leu-norvalinal | Carbobenzoxy-L-leucyl-L-leucyl-L-norvalinal | carbobenzoxy-leucyl-leuc |
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Specifications & Purity | Moligand™, ≥95% |
Biochemical and Physiological Mechanisms | Potent, reversible 20S and 26S proteasome inhibitor (K i values are 21 and 35 nM, respectively). Inhibits chymotrypsin-like activity. Shows proapoptotic effect in vitro . |
Storage Temp | Store at -20°C,Desiccated |
Shipped In | Ice chest + Ice pads |
Grade | Moligand™ |
Note | Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one week. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details. |
Product Description | Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. |
Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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IUPAC Name | benzyl N-[(2S)-4-methyl-1-[[(2S)-4-methyl-1-oxo-1-[[(2S)-1-oxopentan-2-yl]amino]pentan-2-yl]amino]-1-oxopentan-2-yl]carbamate |
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INCHI | InChI=1S/C25H39N3O5/c1-6-10-20(15-29)26-23(30)21(13-17(2)3)27-24(31)22(14-18(4)5)28-25(32)33-16-19-11-8-7-9-12-19/h7-9,11-12,15,17-18,20-22H,6,10,13-14,16H2,1-5H3,(H,26,30)(H,27,31)(H,28,32)/t20-,21-,22-/m0/s1 |
InChi Key | QEJRGURBLQWEOU-FKBYEOEOSA-N |
Canonical SMILES | CCCC(C=O)NC(=O)C(CC(C)C)NC(=O)C(CC(C)C)NC(=O)OCC1=CC=CC=C1 |
Isomeric SMILES | CCC[C@@H](C=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)OCC1=CC=CC=C1 |
PubChem CID | 9868928 |
Molecular Weight | 461.59 |
PubChem CID | 9868928 |
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CAS Registry No. | 133407-86-0 |
ChEMBL Ligand | CHEMBL4518490 |
Enter Lot Number to search for COA:
To view the certificate results,please click on a Lot number.For Lot numbers from past orders,please use our order status section
Lot Number | Certificate Type | Date | Item |
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F2305512 | Certificate of Analysis | May 10, 2024 | M275487 |
F2305506 | Certificate of Analysis | May 10, 2024 | M275487 |
F2305510 | Certificate of Analysis | Apr 11, 2024 | M275487 |
F2305508 | Certificate of Analysis | Apr 11, 2024 | M275487 |
F2305504 | Certificate of Analysis | Apr 11, 2024 | M275487 |
F2305502 | Certificate of Analysis | Apr 11, 2024 | M275487 |
F2305501 | Certificate of Analysis | Mar 19, 2024 | M275487 |
F2305503 | Certificate of Analysis | Mar 19, 2024 | M275487 |
F2305505 | Certificate of Analysis | Mar 19, 2024 | M275487 |
F2305507 | Certificate of Analysis | Mar 19, 2024 | M275487 |
F2305509 | Certificate of Analysis | Mar 19, 2024 | M275487 |
F2305511 | Certificate of Analysis | Mar 19, 2024 | M275487 |
Solubility | Soluble in DMSO |
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1. Mori S, Tanaka K, Omura S, Saito Y. (1995) Degradation process of ligand-stimulated platelet-derived growth factor beta-receptor involves ubiquitin-proteasome proteolytic pathway.. J Biol Chem, 270 (49): (29447-52). [PMID:7493983] |
2. Hirakawa T et al.. (2019) LSD1-LIKE1-Mediated H3K4me2 Demethylation Is Required for Homologous Recombination Repair.. Plant Physiol, 181 (2): (499-509). [PMID:31366719] |