MG-115 - ≥95%, high purity , CAS No.133407-86-0

Item Number
M275487
Grouped product items
SKUSizeAvailabilityPrice Qty
M275487-1mg
1mg
In stock
$119.90
M275487-5mg
5mg
In stock
$266.90
M275487-10mg
10mg
In stock
$424.90
M275487-25mg
25mg
In stock
$956.90
M275487-50mg
50mg
In stock
$1,721.90
M275487-100mg
100mg
In stock
$3,098.90

Potent, reversible proteasome inhibitor

Basic Description

SynonymsMG-115 | Z-LL-Nva-CHO | 133407-86-0 | MG115 | benzyl N-[(2S)-4-methyl-1-[[(2S)-4-methyl-1-oxo-1-[[(2S)-1-oxopentan-2-yl]amino]pentan-2-yl]amino]-1-oxopentan-2-yl]carbamate | Cbz-Leu-Leu-norvalinal | Carbobenzoxy-L-leucyl-L-leucyl-L-norvalinal | carbobenzoxy-leucyl-leuc
Specifications & PurityMoligand™, ≥95%
Biochemical and Physiological MechanismsPotent, reversible 20S and 26S proteasome inhibitor (K i values are 21 and 35 nM, respectively). Inhibits chymotrypsin-like activity. Shows proapoptotic effect in vitro .
Storage TempStore at -20°C,Desiccated
Shipped InIce chest + Ice pads
GradeMoligand™
NoteWherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one week. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description

Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.

Associated Targets(non-human)

rep Replicase polyprotein 1ab (378 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Names and Identifiers

IUPAC Name benzyl N-[(2S)-4-methyl-1-[[(2S)-4-methyl-1-oxo-1-[[(2S)-1-oxopentan-2-yl]amino]pentan-2-yl]amino]-1-oxopentan-2-yl]carbamate
INCHI InChI=1S/C25H39N3O5/c1-6-10-20(15-29)26-23(30)21(13-17(2)3)27-24(31)22(14-18(4)5)28-25(32)33-16-19-11-8-7-9-12-19/h7-9,11-12,15,17-18,20-22H,6,10,13-14,16H2,1-5H3,(H,26,30)(H,27,31)(H,28,32)/t20-,21-,22-/m0/s1
InChi Key QEJRGURBLQWEOU-FKBYEOEOSA-N
Canonical SMILES CCCC(C=O)NC(=O)C(CC(C)C)NC(=O)C(CC(C)C)NC(=O)OCC1=CC=CC=C1
Isomeric SMILES CCC[C@@H](C=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)OCC1=CC=CC=C1
PubChem CID 9868928
Molecular Weight 461.59

Certificates

Certificate of Analysis(COA)

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12 results found

Lot NumberCertificate TypeDateItem
F2305512Certificate of AnalysisMay 10, 2024 M275487
F2305506Certificate of AnalysisMay 10, 2024 M275487
F2305510Certificate of AnalysisApr 11, 2024 M275487
F2305508Certificate of AnalysisApr 11, 2024 M275487
F2305504Certificate of AnalysisApr 11, 2024 M275487
F2305502Certificate of AnalysisApr 11, 2024 M275487
F2305501Certificate of AnalysisMar 19, 2024 M275487
F2305503Certificate of AnalysisMar 19, 2024 M275487
F2305505Certificate of AnalysisMar 19, 2024 M275487
F2305507Certificate of AnalysisMar 19, 2024 M275487
F2305509Certificate of AnalysisMar 19, 2024 M275487
F2305511Certificate of AnalysisMar 19, 2024 M275487

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Chemical and Physical Properties

SolubilitySoluble in DMSO

Related Documents

References

1. Mori S, Tanaka K, Omura S, Saito Y.  (1995)  Degradation process of ligand-stimulated platelet-derived growth factor beta-receptor involves ubiquitin-proteasome proteolytic pathway..  J Biol Chem,  270  (49): (29447-52).  [PMID:7493983]
2. Hirakawa T et al..  (2019)  LSD1-LIKE1-Mediated H3K4me2 Demethylation Is Required for Homologous Recombination Repair..  Plant Physiol,  181  (2): (499-509).  [PMID:31366719]

Solution Calculators