Determine the necessary mass, volume, or concentration for preparing a solution.
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
---|
SKU | Size | Availability | Price | Qty |
---|---|---|---|---|
M349090-10mg | 10mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $122.90 | |
M349090-50mg | 50mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $520.90 |
a muscarinic receptor agonist
Synonyms | MILAMELINE|139886-32-1|Milameline [INN]|UNII-R9X77R42FN|R9X77R42FN|PD-129409|(E)-1,2,5,6-Tetrahydro-1-methyl-3-pyridinecarboxaldehyde O-methyloxime|PD-129,409|(E)-N-methoxy-1-(1-methyl-3,6-dihydro-2H-pyridin-5-yl)methanimine|3-Pyridinecarboxaldehyde, 1,2, |
---|---|
Specifications & Purity | Moligand™, ≥99% |
Storage Temp | Store at -20°C,Desiccated |
Shipped In | Ice chest + Ice pads |
Grade | Moligand™ |
Action Type | AGONIST |
Mechanism of action | Agonist of M 1 receptor;Agonist of M 3 receptor;Agonist of M 4 receptor;Agonist of M 5 receptor |
Product Description | Milameline hydrochloride is a muscarinic receptor agonist that displays roughly equal affinity at all receptor subtypes (Ki values are 2.3, 2.4, 3.6, 3.8 and 4.3 μM for mAChR M1, mAChR M2, mAChR M3, mAChR M4, mAChR M5 (hM1, hM2, hM3, hM4 and hM5 receptors) respectively). Cognitive enhancer; reverses spatial memory deficits in rats. |
Ki Data | hM1 receptor: Ki= 2.3 μM; hM2 receptor: Ki= 2.4 μM; hM3 receptor: Ki= 3.6 μM; hM4 receptor: Ki= 3.8 μM; hM5 receptor: Ki= 4.3 μM |
---|
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
---|
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
---|
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
---|
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
---|
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
---|
IUPAC Name | (E)-N-methoxy-1-(1-methyl-3,6-dihydro-2H-pyridin-5-yl)methanimine |
---|---|
INCHI | InChI=1S/C8H14N2O/c1-10-5-3-4-8(7-10)6-9-11-2/h4,6H,3,5,7H2,1-2H3/b9-6+ |
InChi Key | YMMXHEYLRHNXAB-RMKNXTFCSA-N |
Canonical SMILES | CN1CCC=C(C1)C=NOC |
Isomeric SMILES | CN1CCC=C(C1)/C=N/OC |
RTECS | US4356000 |
PubChem CID | 9571002 |
Molecular Weight | 190.67 |
PubChem CID | 9571002 |
---|---|
BindingDB Ligand | 50282491 |
Wikipedia | Milameline |
CAS Registry No. | 139886-32-1 |
ChEMBL Ligand | CHEMBL151938 |
GPCRdb Ligand | milameline |
Enter Lot Number to search for COA:
Solubility | Soluble in water (100 mM). |
---|---|
Refractive Index | n20D~1.50 (Predicted) |
Pictogram(s) | GHS06 |
---|---|
Signal | Danger |
Hazard Statements | H301:Toxic if swallowed |
Precautionary Statements | P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P270:Do not eat, drink or smoke when using this product. P330:Rinse mouth. P301+P316:IF SWALLOWED: Get emergency medical help immediately. |
RTECS | US4356000 |