Click Here for 5% Off Your First Aladdin Purchase!

Milameline hydrochloride - ≥99%, high purity , CAS No.139886-32-1, Agonist of M 1 receptor;Agonist of M 3 receptor;Agonist of M 4 receptor;Agonist of M 5 receptor

  • Moligand™
  • ≥99%
Item Number
M349090
Grouped product items
SKUSizeAvailabilityPrice Qty
M349090-10mg
10mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$122.90
M349090-50mg
50mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$520.90

a muscarinic receptor agonist

Basic Description

SynonymsMILAMELINE|139886-32-1|Milameline [INN]|UNII-R9X77R42FN|R9X77R42FN|PD-129409|(E)-1,2,5,6-Tetrahydro-1-methyl-3-pyridinecarboxaldehyde O-methyloxime|PD-129,409|(E)-N-methoxy-1-(1-methyl-3,6-dihydro-2H-pyridin-5-yl)methanimine|3-Pyridinecarboxaldehyde, 1,2,
Specifications & PurityMoligand™, ≥99%
Storage TempStore at -20°C,Desiccated
Shipped InIce chest + Ice pads
GradeMoligand™
Action TypeAGONIST
Mechanism of actionAgonist of M 1 receptor;Agonist of M 3 receptor;Agonist of M 4 receptor;Agonist of M 5 receptor
Product Description

Milameline hydrochloride is a muscarinic receptor agonist that displays roughly equal affinity at all receptor subtypes (Ki values are 2.3, 2.4, 3.6, 3.8 and 4.3 μM for mAChR M1, mAChR M2, mAChR M3, mAChR M4, mAChR M5 (hM1, hM2, hM3, hM4 and hM5 receptors) respectively). Cognitive enhancer; reverses spatial memory deficits in rats.

Product Properties

Ki DatahM1 receptor: Ki= 2.3 μM; hM2 receptor: Ki= 2.4 μM; hM3 receptor: Ki= 3.6 μM; hM4 receptor: Ki= 3.8 μM; hM5 receptor: Ki= 4.3 μM

Associated Targets

CHRM5 Tclin Muscarinic acetylcholine receptor M5 1 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

CHRM3 Tclin Muscarinic acetylcholine receptor M3 1 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

CHRM4 Tclin Muscarinic acetylcholine receptor M4 1 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

CHRM2 Tclin Muscarinic acetylcholine receptor M2 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

CHRM1 Tclin Muscarinic acetylcholine receptor M1 2 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

Names and Identifiers

IUPAC Name (E)-N-methoxy-1-(1-methyl-3,6-dihydro-2H-pyridin-5-yl)methanimine
INCHI InChI=1S/C8H14N2O/c1-10-5-3-4-8(7-10)6-9-11-2/h4,6H,3,5,7H2,1-2H3/b9-6+
InChi Key YMMXHEYLRHNXAB-RMKNXTFCSA-N
Canonical SMILES CN1CCC=C(C1)C=NOC
Isomeric SMILES CN1CCC=C(C1)/C=N/OC
RTECS US4356000
PubChem CID 9571002
Molecular Weight 190.67

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

Chemical and Physical Properties

SolubilitySoluble in water (100 mM).
Refractive Indexn20D~1.50 (Predicted)

Safety and Hazards(GHS)

Pictogram(s) GHS06
Signal Danger
Hazard Statements

H301:Toxic if swallowed

Precautionary Statements

P321:Specific treatment (see ... on this label).

P405:Store locked up.

P501:Dispose of contents/container to ...

P264:Wash hands [and …] thoroughly after handling.

P270:Do not eat, drink or smoke when using this product.

P330:Rinse mouth.

P301+P316:IF SWALLOWED: Get emergency medical help immediately.

RTECS US4356000

Related Documents

Solution Calculators