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Minocycline hydrochloride - ≥98%, high purity , CAS No.13614-98-7

8 Citations

≥98%

CAS#: 13614-98-7
Formula: C₂₃H₂₇N₃O₇.HCl
Molecular Weight: 493.94
EC Number: 237-099-7
MDL number: MFCD00083669
PubChem CID: 54685925

Item Number

M102970

Grouped product items
SKU	Size	Availability	Price
M102970-250mg	250mg	In stock	$42.90
M102970-1g	1g	In stock	$131.90
M102970-5g	5g	In stock	$445.90
M102970-25g	25g	In stock	$2,004.90
M102970-100g	100g	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$7,217.90

Antibiotic. Demonstrates multiple effects.

View related series

Tetracycline antibiotics Tetracyclines

Basic Description

Synonyms	Minocycline, Hydrochloride \| Minocyclinhydrochlorid \| BCP06597 \| PD003090 \| M2288 \| Vectrin \| MLS002548863 \| Q2342917 \| ZILXI \| DTXSID8044545 \| (4S,4aS,5aR,12aS)-4,7-bis(dimethylamino)-3,10,12,12a-tetrahydroxy-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetr
Specifications & Purity	≥98%
Storage Temp	Store at 2-8°C
Shipped In	Wet ice
Product Description	Minocycline hydrochloride has been used: · to prepare nanoliposomes to check its effect on macrophages · for the inhibition of neuroinflammation and neuropathic pain · to treat glioma in murine GL261 glioma cells

Names and Identifiers

IUPAC Name	(4S,4aS,5aR,12aR)-4,7-bis(dimethylamino)-1,10,11,12a-tetrahydroxy-3,12-dioxo-4a,5,5a,6-tetrahydro-4H-tetracene-2-carboxamide;hydrochloride
INCHI	InChI=1S/C23H27N3O7.ClH/c1-25(2)12-5-6-13(27)15-10(12)7-9-8-11-17(26(3)4)19(29)16(22(24)32)21(31)23(11,33)20(30)14(9)18(15)28;/h5-6,9,11,17,27-28,31,33H,7-8H2,1-4H3,(H2,24,32);1H/t9-,11-,17-,23-;/m0./s1
InChi Key	WTJXVDPDEQKTCV-VQAITOIOSA-N
Canonical SMILES	CN(C)C1C2CC3CC4=C(C=CC(=C4C(=C3C(=O)C2(C(=C(C1=O)C(=O)N)O)O)O)O)N(C)C.Cl
Isomeric SMILES	CN(C)[C@H]1[C@@H]2C[C@@H]3CC4=C(C=CC(=C4C(=C3C(=O)[C@@]2(C(=C(C1=O)C(=O)N)O)O)O)O)N(C)C.Cl
WGK Germany	3
RTECS	QI7630500
PubChem CID	54685925
Molecular Weight	493.94
Reaxy-Rn	4836328

Certificates

Certificate of Analysis(COA)

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Find and download the COA for your product by matching the lot number on the packaging.

14 results found

Lot Number	Certificate Type	Date	Item
E2409275	Certificate of Analysis	May 20, 2024	M102970
E2409276	Certificate of Analysis	May 20, 2024	M102970
E2409277	Certificate of Analysis	May 20, 2024	M102970
E2409278	Certificate of Analysis	May 20, 2024	M102970
A2426057	Certificate of Analysis	Nov 17, 2022	M102970
L2202568	Certificate of Analysis	Nov 17, 2022	M102970
L2202569	Certificate of Analysis	Nov 17, 2022	M102970
L2202573	Certificate of Analysis	Nov 17, 2022	M102970
L2202574	Certificate of Analysis	Nov 17, 2022	M102970
L2202577	Certificate of Analysis	Nov 17, 2022	M102970
I2213215	Certificate of Analysis	Sep 20, 2022	M102970
K2210240	Certificate of Analysis	Sep 20, 2022	M102970
H2210043	Certificate of Analysis	Aug 16, 2022	M102970
F1822053	Certificate of Analysis	Apr 26, 2022	M102970

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Chemical and Physical Properties

Solubility	Freely soluble in water
Sensitivity	Heat sensitive
Specific Rotation[α]	-170 to -180 deg(C=0.5、0.1mol/L HCl)
Flash Point(°F)	230°F
Flash Point(°C)	>110℃
Boil Point(°C)	813℃
Melt Point(°C)	205-210℃

Safety and Hazards(GHS)

Pictogram(s)	GHS07
Signal	Warning
Hazard Statements	H315:Causes skin irritation H319:Causes serious eye irritation H335:May cause respiratory irritation H362:May cause harm to breast-fed children
Precautionary Statements	P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P260:Do not breathe dust/fume/gas/mist/vapors/spray. P271:Use only outdoors or in a well-ventilated area. P270:Do not eat, drink or smoke when using this product. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P362+P364:Take off contaminated clothing and wash it before reuse. P263:Avoid contact during pregnancy/while nursing. P203:Obtain, read and follow all safety instructions before use. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P318:if exposed or concerned, get medical advice. P337+P317:If eye irritation persists: Get medical help. P332+P317:If skin irritation occurs: Get medical help. P319:Get medical help if you feel unwell.
WGK Germany	3
RTECS	QI7630500
Reaxy-Rn	4836328
Merck Index	6202

Citations of This Product

1. Ting Zhu, Jinyang Chen, Shasha Zeng, Jintao Chen, Chunjiao Qi. (2023) Highly Stable Fluorescent-Traffic-Light Sensor for Point-of-Care Detection of Tetracycline. ACS Sensors, 8 (11): (4272–4280). [PMID:37862265]
2. Fei Tong, Pei Wang, Ziqiang Chen, Yifan Liu, Lianguo Wang, Jun Guo, Zhihua Li, Hu Cai, Junchao Wei. (2023) Combined Ferromagnetic Nanoparticles for Effective Periodontal Biofilm Eradication in Rat Model. International Journal of Nanomedicine, [PMID:37192894]
3. Keke Huang, Xin Liu, Ziru Lv, Di Zhang, Yuling Zhou, Zhiqing Lin, Juan Guo. (2023) MMP9-Responsive Graphene Oxide Quantum Dot-Based Nano-in-Micro Drug Delivery System for Combinatorial Therapy of Choroidal Neovascularization. Small, (2207335). [PMID:36871144]
4. Jinyu An, Xue Jiang, Zhe Wang, Yingqiao Li, Zhiru Zou, Qian Wu, Le Tong, Xifan Mei, He Tian, Chao Wu. (2022) Codelivery of minocycline hydrochloride and dextran sulfate via bionic liposomes for the treatment of spinal cord injury. INTERNATIONAL JOURNAL OF PHARMACEUTICS, 628 (122285). [PMID:36244559]
5. Ling Yang, Jing Yang, Hua Liu, Jingbin Lan, Ying Xu, Xiaobo Wu, Yushan Mao, Dongming Wu, Kejian Pan, Tao Zhang. (2022) Minocycline binds and inhibits LYN activity to prevent STAT3-meditated metastasis of colorectal cancer. International Journal of Biological Sciences, 18 (6): ( 2540–2552). [PMID:35414768]
6. Yule Wang, Huimin Wu, Zhu Han, Hongda Sheng, Yuhan Wu, Yingchao Wang, Xinran Guo, Yan Zhu, Xuecai Li, Yi Wang. (2022) Guhong injection promotes post-stroke functional recovery via attenuating cortical inflammation and apoptosis in subacute stage of ischemic stroke. PHYTOMEDICINE, 99 (154034). [PMID:35276592]
7. Lijuan Yang, Lumin Zeng, Yongqing Tao, Dandan Wang, Kailian Zhang, Meng Tian, Zhining Xia, Die Gao. (2022) Galli Gigerii Endothelium Corneum derived fluorescent carbon dots and their application as sensing platform for nitroimidazoles and cell imaging. MICROCHEMICAL JOURNAL, 174 (107089). [PMID:]
8. Chengzhi Zhou, Yanlong Sun, Fan Zhang, Yuandong Wu. (2021) Degradation of Minocycline by the Adsorption–Catalysis Multifunctional PVDF–PVP–TiO2 Membrane: Degradation Kinetics, Photocatalytic Efficiency, and Toxicity of Products. International Journal of Environmental Research and Public Health, 18 (23): (12339). [PMID:34886061]

References

1. Otsu Y et al.. (2018) Functional Principles of Posterior Septal Inputs to the Medial Habenula.. Cell Rep, 22 (3): (693-705). [PMID:29346767]
2. Li TF et al.. (2016) Ester Hydrolysis Differentially Reduces Aconitine-Induced Anti-hypersensitivity and Acute Neurotoxicity: Involvement of Spinal Microglial Dynorphin Expression and Implications for Aconitum Processing.. Front Pharmacol, 7 (367). [PMID:27761113]
3. M Ohhira,M Yamada,Y Murazumi,M Ohhira,Y Takasugi,M Namiki,T Suzuki. (1995-01-01) [Intracystic infusion therapy of minocycline hydrochloride for benign hepatic cysts].. Nihon Ronen Igakkai zasshi. Japanese journal of geriatrics, 32 ((1)): (33-38). [PMID:7739142]
4. Weidun Alan Guo. (2012-07-07) The search for a magic bullet to fight multiple organ failure secondary to ischemia/reperfusion injury and abdominal compartment syndrome.. The Journal of surgical research, 184 ((2)): (792-793). [PMID:22765997]
5. Shaofeng Pu,Yongming Xu,Dongping Du,Meirong Yang,Xin Zhang,Junzhen Wu,Wei Jiang. (2012-11-01) Minocycline attenuates mechanical allodynia and expression of spinal NMDA receptor 1 subunit in rat neuropathic pain model.. Journal of physiology and biochemistry, 69 ((3)): (349-357). [PMID:23111678]
6. Christine L Miller. (2013-02-01) On the mechanism of action of antipsychotic drugs: a chemical reaction not receptor blockade.. Current drug discovery technologies, 10 ((3)): (195-208). [PMID:23363232]
7. Christopher L Cunningham,Verónica Martínez-Cerdeño,Stephen C Noctor. (2013-03-08) Microglia regulate the number of neural precursor cells in the developing cerebral cortex.. The Journal of neuroscience : the official journal of the Society for Neuroscience, 33 ((10)): (4216-4233). [PMID:23467340]
8. Jin-Shing Chen,Wing-Kai Chan,Kung-Tsao Tsai,Hsao-Hsun Hsu,Chien-Yu Lin,Ang Yuan,Wen-Jone Chen,Hong-Shiee Lai,Pan-Chyr Yang. (2013-03-16) Simple aspiration and drainage and intrapleural minocycline pleurodesis versus simple aspiration and drainage for the initial treatment of primary spontaneous pneumothorax: an open-label, parallel-group, prospective, randomised, controlled trial.. Lancet (London, England), 381 ((9874)): (1277-1282). [PMID:23489754]
9. Pyng Lee. (2013-03-16) Primary spontaneous pneumothorax: to pleurodese or not?. Lancet (London, England), 381 ((9874)): (1252-1254). [PMID:23489755]
10. Xuqing Liu,Huanxing Su,Tak-Ho Chu,Anchen Guo,Wutian Wu. (2013-03-23) Minocycline inhibited the pro-apoptotic effect of microglia on neural progenitor cells and protected their neuronal differentiation in vitro.. Neuroscience letters, 542 (30-36). [PMID:23518153]
11. Leandro F S Bastos,Adriana M Godin,Yingning Zhang,Suwatchai Jarussophon,Bruno C S Ferreira,Renes R Machado,Steven F Maier,Yasuo Konishi,Rossimiriam P de Freitas,Bernd L Fiebich,Linda R Watkins,Márcio M Coelho,Márcio F D Moraes. (2013-03-26) A minocycline derivative reduces nerve injury-induced allodynia, LPS-induced prostaglandin E2 microglial production and signaling via toll-like receptors 2 and 4.. Neuroscience letters, 543 (157-162). [PMID:23523650]
12. J Mark Jackson,Leon H Kircik,Douglas J Lorenz. (2013-04-03) Efficacy of extended-release 45 mg oral minocycline and extended-release 45 mg oral minocycline plus 15% azelaic acid in the treatment of acne rosacea.. Journal of drugs in dermatology : JDD, 12 ((3)): (292-298). [PMID:23545911]
13. Tatsuhide Tanaka,Koichi Murakami,Yoshio Bando,Shigetaka Yoshida. (2013-05-08) Minocycline reduces remyelination by suppressing ciliary neurotrophic factor expression after cuprizone-induced demyelination.. Journal of neurochemistry, 127 ((2)): (259-270). [PMID:23647102]
14. M V Ghica,M G Albu,L Popa,St Moisescu. (2013-06-28) Response surface methodology and Taguchi approach to assess the combined effect of formulation factors on minocycline delivery from collagen sponges.. Die Pharmazie, 68 ((5)): (340-348). [PMID:23802431]
15. Kenji Hashimoto,Tamaki Ishima,Yuko Fujita,Lin Zhang. (2013-07-03) [Antibiotic drug minocycline: a potential therapeutic drug for methamphetamine-related disorders].. Nihon Arukoru Yakubutsu Igakkai zasshi = Japanese journal of alcohol studies & drug dependence, 48 ((2)): (118-125). [PMID:23808319]
16. Ana Belen Lopez-Rodriguez,Eleni Siopi,David P Finn,Catherine Marchand-Leroux,Luis M Garcia-Segura,Mehrnaz Jafarian-Tehrani,Maria-Paz Viveros. (2013-08-21) CB1 and CB2 cannabinoid receptor antagonists prevent minocycline-induced neuroprotection following traumatic brain injury in mice.. Cerebral cortex (New York, N.Y. : 1991), 25 ((1)): (35-45). [PMID:23960212]
17. Justin Schwartz,Ekhson Holmuhamedov,Xun Zhang,Gregory L Lovelace,Charles D Smith,John J Lemasters. (2013-09-10) Minocycline and doxycycline, but not other tetracycline-derived compounds, protect liver cells from chemical hypoxia and ischemia/reperfusion injury by inhibition of the mitochondrial calcium uniporter.. Toxicology and applied pharmacology, 273 ((1)): (172-179). [PMID:24012766]
18. Min Jung Kwon,Jinha Kim,Haeyoung Shin,Soo Ryeong Jeong,Young Mi Kang,Jun Young Choi,Dong Hoon Hwang,Byung Gon Kim. (2013-09-21) Contribution of macrophages to enhanced regenerative capacity of dorsal root ganglia sensory neurons by conditioning injury.. The Journal of neuroscience : the official journal of the Society for Neuroscience, 33 ((38)): (15095-15108). [PMID:24048840]
19. Scott A Davis,Steven R Feldman. (2013-11-01) Patterns of ambulatory care usage and leading treatments for rosacea.. The Journal of dermatological treatment, 25 ((4)): (275-277). [PMID:24171399]
20. Alfred D Kinana,Attilio V Vargiu,Hiroshi Nikaido. (2013-11-12) Some ligands enhance the efflux of other ligands by the Escherichia coli multidrug pump AcrB.. Biochemistry, 52 ((46)): (8342-8351). [PMID:24205856]
21. Maneesh Singh,Pratibha Singh,Dolores Vaira,Mathieu Amand,Souad Rahmouni,Michel Moutschen. (2014-01-15) Minocycline attenuates HIV-1 infection and suppresses chronic immune activation in humanized NOD/LtsZ-scidIL-2Rγ(null) mice.. Immunology, 142 ((4)): (562-572). [PMID:24409837]
22. Thomas Schmitz,Grietje Krabbe,Georg Weikert,Till Scheuer,Friederike Matheus,Yan Wang,Susanne Mueller,Helmut Kettenmann,Vitali Matyash,Christoph Bührer,Stefanie Endesfelder. (2014-02-05) Minocycline protects the immature white matter against hyperoxia.. Experimental neurology, 254 (153-165). [PMID:24491957]
23. Julia L Drewes,Gregory L Szeto,Elizabeth L Engle,Zhaohao Liao,Gene M Shearer,M Christine Zink,David R Graham. (2014-04-16) Attenuation of pathogenic immune responses during infection with human and simian immunodeficiency virus (HIV/SIV) by the tetracycline derivative minocycline.. PloS one, 9 ((4)): (e94375-e94375). [PMID:24732038]
24. Giampaolo Bucaneve,Alessandra Micozzi,Marco Picardi,Stelvio Ballanti,Nicola Cascavilla,Prassede Salutari,Giorgina Specchia,Rosa Fanci,Mario Luppi,Laura Cudillo,Renato Cantaffa,Giuseppe Milone,Monica Bocchia,Giovanni Martinelli,Massimo Offidani,Anna Chierichini,Francesco Fabbiano,Giovanni Quarta,Valeria Primon,Bruno Martino,Annunziata Manna,Eliana Zuffa,Antonella Ferrari,Giuseppe Gentile,Robin Foà,Albano Del Favero. (2014-04-16) Results of a multicenter, controlled, randomized clinical trial evaluating the combination of piperacillin/tazobactam and tigecycline in high-risk hematologic patients with cancer with febrile neutropenia.. Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 32 ((14)): (1463-1471). [PMID:24733807]
25. Wen-tao Ni,Bei-bei Liang,Yun Cai,Yin-ping Liu,Nan Bai,Jun-chang Cui,Rui Wang. (2014-05-09) A pharmacodynamic simulation to evaluate tigecycline in treatment of nosocomial pneumonia caused by multidrug-resistant Acinetobacter baumannii.. Pakistan journal of pharmaceutical sciences, 27 ((3)): (463-467). [PMID:24811802]
26. Joanna Mika,Katarzyna Popiolek-Barczyk,Ewelina Rojewska,Wioletta Makuch,Katarzyna Starowicz,Barbara Przewlocka. (2014-08-12) Delta-opioid receptor analgesia is independent of microglial activation in a rat model of neuropathic pain.. PloS one, 9 ((8)): (e104420-e104420). [PMID:25105291]
27. Larry Wong,Joseph D Done,Anthony J Schaeffer,Praveen Thumbikat. (2014-09-30) Experimental autoimmune prostatitis induces microglial activation in the spinal cord.. The Prostate, 75 ((1)): (50-59). [PMID:25263093]
28. Simon Gritsch,Jianning Lu,Sebastian Thilemann,Simone Wörtge,Wiebke Möbius,Julia Bruttger,Khalad Karram,Torben Ruhwedel,Michaela Blanfeld,Daniel Vardeh,Ari Waisman,Klaus-Armin Nave,Rohini Kuner. (2014-12-02) Oligodendrocyte ablation triggers central pain independently of innate or adaptive immune responses in mice.. Nature communications, 5 (5472-5472). [PMID:25434649]
29. Nico T Mutters,Guido Werner,Evelina Tacconelli,Alexander Mischnik. (2015-01-13) [Treatment options for serious infections caused by vancomycin-resistant enterococci].. Deutsche medizinische Wochenschrift (1946), 140 ((1)): (42-45). [PMID:25580973]
30. Wonil Lee,Minho Moon,Hyo Geun Kim,Tae Hee Lee,Myung Sook Oh. (2015-05-24) Heat stress-induced memory impairment is associated with neuroinflammation in mice.. Journal of neuroinflammation, 12 (102-102). [PMID:26001832]
31. Mona Fares,Manuchehr Abedi-Valugerdi,Moustapha Hassan,Zuzana Potácová. (2015-05-30) DNA damage, lysosomal degradation and Bcl-xL deamidation in doxycycline- and minocycline-induced cell death in the K562 leukemic cell line.. Biochemical and biophysical research communications, 463 ((3)): (268-274). [PMID:26022120]
32. Anna M W Taylor,Annie Castonguay,Alison J Taylor,Niall P Murphy,Atefeh Ghogha,Christopher Cook,Lihua Xue,Mary C Olmstead,Yves De Koninck,Christopher J Evans,Catherine M Cahill. (2015-06-05) Microglia disrupt mesolimbic reward circuitry in chronic pain.. The Journal of neuroscience : the official journal of the Society for Neuroscience, 35 ((22)): (8442-8450). [PMID:26041913]
33. Anne C Solga,Winnie W Pong,Keun-Young Kim,Patrick J Cimino,Joseph A Toonen,Jason Walker,Todd Wylie,Vincent Magrini,Malachi Griffith,Obi L Griffith,Amy Ly,Mark H Ellisman,Elaine R Mardis,David H Gutmann. (2015-11-21) RNA Sequencing of Tumor-Associated Microglia Reveals Ccl5 as a Stromal Chemokine Critical for Neurofibromatosis-1 Glioma Growth.. Neoplasia (New York, N.Y.), 17 ((10)): (776-788). [PMID:26585233]
34. Hongsheng Miao,Runming Li,Cong Han,Xiuzhen Lu,Hang Zhang. (2018-05-24) Minocycline promotes posthemorrhagic neurogenesis via M2 microglia polarization via upregulation of the TrkB/BDNF pathway in rats.. Journal of neurophysiology, 120 ((3)): (1307-1317). [PMID:29790836]
35. Teresa Fernandez-Zafra,Tianle Gao,Alexandra Jurczak,Katalin Sandor,Zoe Hore,Nilesh M Agalave,Jie Su,Johanna Estelius,Jon Lampa,Tomas Hokfelt,Zsuzsanna Wiesenfeld-Hallin,Xiaojun Xu,Franziska Denk,Camilla I Svensson. (2018-09-25) Exploring the transcriptome of resident spinal microglia after collagen antibody-induced arthritis.. Pain, 160 ((1)): (224-236). [PMID:30247264]
36. Zsuzsanna Winkler,Dániel Kuti,Ágnes Polyák,Balázs Juhász,Krisztina Gulyás,Nikolett Lénárt,Ádám Dénes,Szilamér Ferenczi,Krisztina J Kovács. (2019-04-19) Hypoglycemia-activated Hypothalamic Microglia Impairs Glucose Counterregulatory Responses.. Scientific reports, 9 ((1)): (6224-6224). [PMID:30996341]
37. Koichiro Haruwaka,Ako Ikegami,Yoshihisa Tachibana,Nobuhiko Ohno,Hiroyuki Konishi,Akari Hashimoto,Mami Matsumoto,Daisuke Kato,Riho Ono,Hiroshi Kiyama,Andrew J Moorhouse,Junichi Nabekura,Hiroaki Wake. (2019-12-22) Dual microglia effects on blood brain barrier permeability induced by systemic inflammation.. Nature communications, 10 ((1)): (5816-5816). [PMID:31862977]
38. Shao-Yu Guan,Kun Zhang,Xin-Shang Wang,Le Yang,Bin Feng,Dan-Dan Tian,Mei-Rong Gao,Shui-Bing Liu,An Liu,Ming-Gao Zhao. (2020-01-23) Anxiolytic effects of polydatin through the blockade of neuroinflammation in a chronic pain mouse model.. Molecular pain, 16 (1744806919900717-1744806919900717). [PMID:31964240]
39. Fei Lin,Yuxin Zheng,Linghui Pan,Zhiyi Zuo. (2020-03-26) Attenuation of noisy environment-induced neuroinflammation and dysfunction of learning and memory by minocycline during perioperative period in mice.. Brain research bulletin, 159 (16-24). [PMID:32208177]
40. Xinxin Zhou,Lei Tao,Mengru Zhao,Shengjun Wu,Enoch Obeng,Dan Wang,Wenping Zhang. (2020-05-02) Wnt/β-catenin signaling regulates brain-derived neurotrophic factor release from spinal microglia to mediate HIV1 gp120-induced neuropathic pain.. Molecular pain, 16 (1744806920922100-1744806920922100). [PMID:32354292]
41. Bo Wang,Xiao Huang,Xiao Pan,Ting Zhang,Cheng Hou,Wen-Jun Su,Lin-Lin Liu,Jia-Mei Li,Yun-Xia Wang. (2020-06-20) Minocycline prevents the depressive-like behavior through inhibiting the release of HMGB1 from microglia and neurons.. Brain, behavior, and immunity, 88 (132-143). [PMID:32553784]
42. Koichi Sato,Ayaka Tobo,Chihiro Mogi,Masayuki Tobo,Nobuhiro Yamane,Masahiko Tosaka,Hideaki Tomura,Dong-Soon Im,Fumikazu Okajima. (2020-10-16) The protective role of proton-sensing TDAG8 in the brain injury in a mouse ischemia reperfusion model.. Scientific reports, 10 ((1)): (17193-17193). [PMID:33057165]
43. Sergio M Borghi,Victor Fattori,Thacyana T Carvalho,Vera L H Tatakihara,Tiago H Zaninelli,Felipe A Pinho-Ribeiro,Camila R Ferraz,Larissa Staurengo-Ferrari,Rubia Casagrande,Wander R Pavanelli,Fernando Q Cunha,Thiago M Cunha,Phileno Pinge-Filho,Waldiceu A Verri. (2021-02-13) Experimental Trypanosoma cruzi Infection Induces Pain in Mice Dependent on Early Spinal Cord Glial Cells and NFκB Activation and Cytokine Production.. Frontiers in immunology, 11 (539086-539086). [PMID:33574810]
44. R J Tamargo,R A Bok,H Brem. (1991-01-15) Angiogenesis inhibition by minocycline.. Cancer research, 51 ((2)): (672-675). [PMID:1702361]
45. S Gilbertson-Beadling,E A Powers,M Stamp-Cole,P S Scott,T L Wallace,J Copeland,G Petzold,M Mitchell,S Ledbetter,R Poorman. (1995-01-01) The tetracycline analogs minocycline and doxycycline inhibit angiogenesis in vitro by a non-metalloproteinase-dependent mechanism.. Cancer chemotherapy and pharmacology, 36 ((5)): (418-424). [PMID:7543375]
46. Shamama Javed,Kanchan Kohli. (2010-10-19) Local delivery of minocycline hydrochloride: a therapeutic paradigm in periodontal diseases.. Current drug delivery, 7 ((5)): (398-406). [PMID:20950268]
47. Mohamed Hamed Al-Agamy. (2013-03-05) Phenotypic and molecular characterization of extended-spectrum β-lactamases and AmpC β-lactamases in Klebsiella pneumoniae.. Pakistan journal of pharmaceutical sciences, 26 ((2)): (291-298). [PMID:23455199]
48. Satoshi Ikegaya,Hiromichi Iwasaki,Nobuhiro Takada,Seigo Yamamoto,Takanori Ueda. (2013-04-17) Tsutsugamushi disease caused by Shimokoshi-type Orientia tsutsugamushi: the first report in Western Japan.. The American journal of tropical medicine and hygiene, 88 ((6)): (1217-1219). [PMID:23589529]
49. Jaclyn L Kovach,Bradley T Kovach. (2013-05-24) Minocycline-induced scleral and dermal pigmentation.. JAMA ophthalmology, 131 ((5)): (608-608). [PMID:23699840]
50. Maik M A Worlitzer,Thomas Viel,Andreas H Jacobs,Jens C Schwamborn. (2013-06-06) The majority of newly generated cells in the adult mouse substantia nigra express low levels of Doublecortin, but their proliferation is unaffected by 6-OHDA-induced nigral lesion or Minocycline-mediated inhibition of neuroinflammation.. The European journal of neuroscience, 38 ((5)): (2684-2692). [PMID:23734736]
51. Hui-Wen Tseng,Hui-Hwa Tseng,Chieh-Shan Wu. (2013-06-15) Confluent and reticulate papillomatosis treated with minocycline and tazarotene.. Cutis, 91 ((4)): (194-197). [PMID:23763080]
52. Alkystis Phinikaridou,Marcelo E Andia,Gabriella Passacquale,Albert Ferro,Rene M Botnar. (2013-09-28) Noninvasive MRI monitoring of the effect of interventions on endothelial permeability in murine atherosclerosis using an albumin-binding contrast agent.. Journal of the American Heart Association, 2 ((5)): (e000402-e000402). [PMID:24072533]
53. Feng Hu,Min-Chi Ku,Darko Markovic,Omar Dildar a Dzaye,Seija Lehnardt,Michael Synowitz,Susanne A Wolf,Helmut Kettenmann. (2014-04-23) Glioma-associated microglial MMP9 expression is upregulated by TLR2 signaling and sensitive to minocycline.. International journal of cancer, 135 ((11)): (2569-2578). [PMID:24752463]
54. Vishnusai Chauhan,Catherine McDougall. (2014-07-22) Black bones: minocycline-induced bone pigmentation.. The Medical journal of Australia, 201 ((2)): (114-114). [PMID:25045993]
55. Kazuko Ishiguro,Jumpei Washio,Keiichi Sasaki,Nobuhiro Takahashi. (2015-05-20) Real-time monitoring of the metabolic activity of periodontopathic bacteria.. Journal of microbiological methods, 115 (22-26). [PMID:25986950]
56. Irene Sanchez-Brualla,Aina Calls-Cobos,Esther Udina. (2018-05-02) Minocycline Does Not Reduce the Regenerative Capacity of Peripheral Motor and Sensory Neurons after a Conditioning Injury in Mice.. Anatomical record (Hoboken, N.J. : 2007), 301 ((10)): (1638-1645). [PMID:29710422]
57. Xiaoxia Huang,Jinyuan Li,Jin Xie,Yang Li,Yan Gao,Xiaohui Li,Xueqin Xu,Ruoshi Shi,Wanjun Yao,Changbin Ke. (2018-06-18) Neuronal complement cascade drives bone cancer pain via C3R mediated microglial activation.. Brain research, 1698 (81-88). [PMID:29909203]
58. Mariana Alves,Laura De Diego Garcia,Giorgia Conte,Eva M Jimenez-Mateos. (2019-05-03) Context-Specific Switch from Anti- to Pro-epileptogenic Function of the P2Y1 Receptor in Experimental Epilepsy.. The Journal of neuroscience : the official journal of the Society for Neuroscience, 39 ((27)): (5377-5392). [PMID:31048325]
59. Mariana Alves,Jonathon Smith,Tobias Engel. (2020-02-06) Differential Expression of the Metabotropic P2Y Receptor Family in the Cortex Following Status Epilepticus and Neuroprotection via P2Y1 Antagonism in Mice.. Frontiers in pharmacology, 10 (1558-1558). [PMID:32009961]
60. Jessie Goins,Nicholas Henkel,Aminata P Coulibaly,Lori G Isaacson. (2020-04-27) Activated Microglia in the Rat Spinal Cord Following Peripheral Axon Injury Promote Glial and Neuronal Plasticity Which is Necessary for Long-Term Neuronal Survival.. Cellular and molecular neurobiology, 41 ((2)): (309-326). [PMID:32335774]
61. Tian Yuan,Krishna Manohar,Rocco Latorre,Albert Orock,Beverley Greenwood-Van Meerveld. (2020-05-15) Inhibition of Microglial Activation in the Amygdala Reverses Stress-Induced Abdominal Pain in the Male Rat.. Cellular and molecular gastroenterology and hepatology, 10 ((3)): (527-543). [PMID:32408032]
62. Zhehao Xu,Zhiqiang Qin,Jingcheng Zhang,Yue Wang. (2020-06-26) Microglia-mediated chronic psoriatic itch induced by imiquimod.. Molecular pain, 16 (1744806920934998-1744806920934998). [PMID:32580615]
63. Juhee Kim,Jong-Heon Kim,Ji Yeon Do,Jung Yi Lee,Ryoji Yanai,In-Kyu Lee,Kyoungho Suk,Dong Ho Park. (2021-03-16) Key Role of Microglial Matrix Metalloproteinases in Choroidal Neovascularization.. Frontiers in cellular neuroscience, 15 (638098-638098). [PMID:33716674]
64. Diego Romero-Miguel,Marta Casquero-Veiga,Karina S MacDowell,Sonia Torres-Sanchez,José Antonio Garcia-Partida,Nicolás Lamanna-Rama,Ana Romero-Miranda,Esther Berrocoso,Juan C Leza,Manuel Desco,María Luisa Soto-Montenegro. (2021-06-25) A Characterization of the Effects of Minocycline Treatment During Adolescence on Structural, Metabolic, and Oxidative Stress Parameters in a Maternal Immune Stimulation Model of Neurodevelopmental Brain Disorders.. The international journal of neuropsychopharmacology, 24 ((9)): (734-748). [PMID:34165516]
65. Jian Wang,Xiao-Chen Wu,Ming-Ming Zhang,Jia-Hao Ren,Yi Sun,Jing-Zhen Liu,Xi-Qiang Wu,Si-Yi He,Yun-Qing Li,Jin-Bao Zhang. (2021-10-06) Spinal cord stimulation reduces cardiac pain through microglial deactivation in rats with chronic myocardial ischemia.. Molecular medicine reports, 24 ((6)): [PMID:34608504]
66. Ting Zhu, Jinyang Chen, Shasha Zeng, Jintao Chen, Chunjiao Qi. (2023) Highly Stable Fluorescent-Traffic-Light Sensor for Point-of-Care Detection of Tetracycline. ACS Sensors, 8 (11): (4272–4280). [PMID:37862265]
67. Fei Tong, Pei Wang, Ziqiang Chen, Yifan Liu, Lianguo Wang, Jun Guo, Zhihua Li, Hu Cai, Junchao Wei. (2023) Combined Ferromagnetic Nanoparticles for Effective Periodontal Biofilm Eradication in Rat Model. International Journal of Nanomedicine, [PMID:37192894]
68. Keke Huang, Xin Liu, Ziru Lv, Di Zhang, Yuling Zhou, Zhiqing Lin, Juan Guo. (2023) MMP9-Responsive Graphene Oxide Quantum Dot-Based Nano-in-Micro Drug Delivery System for Combinatorial Therapy of Choroidal Neovascularization. Small, (2207335). [PMID:36871144]
69. Jinyu An, Xue Jiang, Zhe Wang, Yingqiao Li, Zhiru Zou, Qian Wu, Le Tong, Xifan Mei, He Tian, Chao Wu. (2022) Codelivery of minocycline hydrochloride and dextran sulfate via bionic liposomes for the treatment of spinal cord injury. INTERNATIONAL JOURNAL OF PHARMACEUTICS, 628 (122285). [PMID:36244559]
70. Ling Yang, Jing Yang, Hua Liu, Jingbin Lan, Ying Xu, Xiaobo Wu, Yushan Mao, Dongming Wu, Kejian Pan, Tao Zhang. (2022) Minocycline binds and inhibits LYN activity to prevent STAT3-meditated metastasis of colorectal cancer. International Journal of Biological Sciences, 18 (6): ( 2540–2552). [PMID:35414768]
71. Yule Wang, Huimin Wu, Zhu Han, Hongda Sheng, Yuhan Wu, Yingchao Wang, Xinran Guo, Yan Zhu, Xuecai Li, Yi Wang. (2022) Guhong injection promotes post-stroke functional recovery via attenuating cortical inflammation and apoptosis in subacute stage of ischemic stroke. PHYTOMEDICINE, 99 (154034). [PMID:35276592]
72. Lijuan Yang, Lumin Zeng, Yongqing Tao, Dandan Wang, Kailian Zhang, Meng Tian, Zhining Xia, Die Gao. (2022) Galli Gigerii Endothelium Corneum derived fluorescent carbon dots and their application as sensing platform for nitroimidazoles and cell imaging. MICROCHEMICAL JOURNAL, 174 (107089). [PMID:]
73. Chengzhi Zhou, Yanlong Sun, Fan Zhang, Yuandong Wu. (2021) Degradation of Minocycline by the Adsorption–Catalysis Multifunctional PVDF–PVP–TiO2 Membrane: Degradation Kinetics, Photocatalytic Efficiency, and Toxicity of Products. International Journal of Environmental Research and Public Health, 18 (23): (12339). [PMID:34886061]

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