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Minocycline hydrochloride - ≥98%, high purity , CAS No.13614-98-7

11 Citations

≥98%

CAS#: 13614-98-7
Formula: C₂₃H₂₇N₃O₇.HCl
Molecular Weight: 493.94
EC Number: 237-099-7
MDL number: MFCD00083669
PubChem CID: 54685925

Item Number

M102970

Grouped product items
SKU	Size	Availability	Price
M102970-250mg	250mg	In stock	$42.90
M102970-1g	1g	In stock	$131.90
M102970-5g	5g	In stock	$445.90
M102970-25g	25g	In stock	$2,004.90
M102970-100g	100g	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$7,217.90

Antibiotic. Demonstrates multiple effects.

View related series

Anti-infection Antibiotic Apoptosis Bacterial Calcium Channel HIF/HIF Prolyl-Hydroxylase MDM-2/p53 Membrane Transporter/Ion Channel Metabolic Enzyme/Protease Neuronal Signaling Potassium Channel Tetracycline antibiotics Tetracyclines

Basic Description

Synonyms	Minocycline, Hydrochloride \| Minocyclinhydrochlorid \| BCP06597 \| PD003090 \| M2288 \| Vectrin \| MLS002548863 \| Q2342917 \| ZILXI \| DTXSID8044545 \| (4S,4aS,5aR,12aS)-4,7-bis(dimethylamino)-3,10,12,12a-tetrahydroxy-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetr
Specifications & Purity	≥98%
Biochemical and Physiological Mechanisms	Minocycline is a tetracycline antibiotic with neuroprotective, antiapoptotic, anti-inflammatory and antimicrobial effects. Minocycline acts as a matrix metalloproteinase (MMP) inhibitor; attenuates disease severity in mouse models of multiple sclerosis. M
Storage Temp	Store at 2-8°C
Shipped In	Wet ice
Note	Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description	Minocycline hydrochloride has been used: · to prepare nanoliposomes to check its effect on macrophages · for the inhibition of neuroinflammation and neuropathic pain · to treat glioma in murine GL261 glioma cells

Names and Identifiers

IUPAC Name	(4S,4aS,5aR,12aR)-4,7-bis(dimethylamino)-1,10,11,12a-tetrahydroxy-3,12-dioxo-4a,5,5a,6-tetrahydro-4H-tetracene-2-carboxamide;hydrochloride
INCHI	InChI=1S/C23H27N3O7.ClH/c1-25(2)12-5-6-13(27)15-10(12)7-9-8-11-17(26(3)4)19(29)16(22(24)32)21(31)23(11,33)20(30)14(9)18(15)28;/h5-6,9,11,17,27-28,31,33H,7-8H2,1-4H3,(H2,24,32);1H/t9-,11-,17-,23-;/m0./s1
InChi Key	WTJXVDPDEQKTCV-VQAITOIOSA-N
Canonical SMILES	CN(C)C1C2CC3CC4=C(C=CC(=C4C(=C3C(=O)C2(C(=C(C1=O)C(=O)N)O)O)O)O)N(C)C.Cl
Isomeric SMILES	CN(C)[C@H]1[C@@H]2C[C@@H]3CC4=C(C=CC(=C4C(=C3C(=O)[C@@]2(C(=C(C1=O)C(=O)N)O)O)O)O)N(C)C.Cl
WGK Germany	3
RTECS	QI7630500
PubChem CID	54685925
Molecular Weight	493.94
Reaxy-Rn	4836328

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

Find and download the COA for your product by matching the lot number on the packaging.

14 results found

Lot Number	Certificate Type	Date	Item
E2409275	Certificate of Analysis	May 20, 2024	M102970
E2409276	Certificate of Analysis	May 20, 2024	M102970
E2409277	Certificate of Analysis	May 20, 2024	M102970
E2409278	Certificate of Analysis	May 20, 2024	M102970
A2426057	Certificate of Analysis	Nov 17, 2022	M102970
L2202568	Certificate of Analysis	Nov 17, 2022	M102970
L2202569	Certificate of Analysis	Nov 17, 2022	M102970
L2202573	Certificate of Analysis	Nov 17, 2022	M102970
L2202574	Certificate of Analysis	Nov 17, 2022	M102970
L2202577	Certificate of Analysis	Nov 17, 2022	M102970
I2213215	Certificate of Analysis	Sep 20, 2022	M102970
K2210240	Certificate of Analysis	Sep 20, 2022	M102970
H2210043	Certificate of Analysis	Aug 16, 2022	M102970
F1822053	Certificate of Analysis	Apr 26, 2022	M102970

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Chemical and Physical Properties

Solubility	Freely soluble in water
Sensitivity	Heat sensitive
Specific Rotation[α]	-170 to -180 deg(C=0.5、0.1mol/L HCl)
Flash Point(°F)	230°F
Flash Point(°C)	>110℃
Boil Point(°C)	813℃
Melt Point(°C)	205-210℃

Safety and Hazards(GHS)

Pictogram(s)	GHS07
Signal	Warning
Hazard Statements	H315:Causes skin irritation H319:Causes serious eye irritation H335:May cause respiratory irritation H362:May cause harm to breast-fed children
Precautionary Statements	P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P260:Do not breathe dust/fume/gas/mist/vapors/spray. P271:Use only outdoors or in a well-ventilated area. P270:Do not eat, drink or smoke when using this product. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P362+P364:Take off contaminated clothing and wash it before reuse. P263:Avoid contact during pregnancy/while nursing. P203:Obtain, read and follow all safety instructions before use. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P318:if exposed or concerned, get medical advice. P337+P317:If eye irritation persists: Get medical help. P332+P317:If skin irritation occurs: Get medical help. P319:Get medical help if you feel unwell.
WGK Germany	3
RTECS	QI7630500
Reaxy-Rn	4836328
Merck Index	6202

Citations of This Product

How to Cite Aladdin Scientific Products?

1. Ting Zhu, Jinyang Chen, Shasha Zeng, Jintao Chen, Chunjiao Qi. (2023) Highly Stable Fluorescent-Traffic-Light Sensor for Point-of-Care Detection of Tetracycline. ACS Sensors, 8 (11): (4272–4280). [PMID:37862265] [10.1021/acssensors.3c01620]
2. Fei Tong, Pei Wang, Ziqiang Chen, Yifan Liu, Lianguo Wang, Jun Guo, Zhihua Li, Hu Cai, Junchao Wei. (2023) Combined Ferromagnetic Nanoparticles for Effective Periodontal Biofilm Eradication in Rat Model. International Journal of Nanomedicine, [PMID:37192894] [10.2147/IJN.S402410]
3. Keke Huang, Xin Liu, Ziru Lv, Di Zhang, Yuling Zhou, Zhiqing Lin, Juan Guo. (2023) MMP9-Responsive Graphene Oxide Quantum Dot-Based Nano-in-Micro Drug Delivery System for Combinatorial Therapy of Choroidal Neovascularization. Small, (2207335). [PMID:36871144] [10.1002/smll.202207335]
4. Jinyu An, Xue Jiang, Zhe Wang, Yingqiao Li, Zhiru Zou, Qian Wu, Le Tong, Xifan Mei, He Tian, Chao Wu. (2022) Codelivery of minocycline hydrochloride and dextran sulfate via bionic liposomes for the treatment of spinal cord injury. INTERNATIONAL JOURNAL OF PHARMACEUTICS, 628 (122285). [PMID:36244559] [10.1016/j.ijpharm.2022.122285]
5. Ling Yang, Jing Yang, Hua Liu, Jingbin Lan, Ying Xu, Xiaobo Wu, Yushan Mao, Dongming Wu, Kejian Pan, Tao Zhang. (2022) Minocycline binds and inhibits LYN activity to prevent STAT3-meditated metastasis of colorectal cancer. International Journal of Biological Sciences, 18 (6): ( 2540–2552). [PMID:35414768] [10.7150/ijbs.70708]
6. Yule Wang, Huimin Wu, Zhu Han, Hongda Sheng, Yuhan Wu, Yingchao Wang, Xinran Guo, Yan Zhu, Xuecai Li, Yi Wang. (2022) Guhong injection promotes post-stroke functional recovery via attenuating cortical inflammation and apoptosis in subacute stage of ischemic stroke. PHYTOMEDICINE, 99 (154034). [PMID:35276592] [10.1016/j.phymed.2022.154034]
7. Lijuan Yang, Lumin Zeng, Yongqing Tao, Dandan Wang, Kailian Zhang, Meng Tian, Zhining Xia, Die Gao. (2022) Galli Gigerii Endothelium Corneum derived fluorescent carbon dots and their application as sensing platform for nitroimidazoles and cell imaging. MICROCHEMICAL JOURNAL, 174 (107089). [PMID:] [10.1016/j.microc.2021.107089]
8. Chengzhi Zhou, Yanlong Sun, Fan Zhang, Yuandong Wu. (2021) Degradation of Minocycline by the Adsorption–Catalysis Multifunctional PVDF–PVP–TiO2 Membrane: Degradation Kinetics, Photocatalytic Efficiency, and Toxicity of Products. International Journal of Environmental Research and Public Health, 18 (23): (12339). [PMID:34886061] [10.3390/ijerph182312339]
9. Lijuan Yang, Jing Zeng, Tian Quan, Shaochi Liu, Linlin Deng, Xun Kang, Zhining Xia, Die Gao. (2021) Liquid-liquid extraction and purification of oil red O derived nitrogen-doped highly photoluminescent carbon dots and their application as multi-functional sensing platform for Cu2+ and tetracycline antibiotics. MICROCHEMICAL JOURNAL, 168 (106391). [PMID:] [10.1016/j.microc.2021.106391]
10. Xiao-Juan Wang, Gao-Feng Shu, Xiao-Ling Xu, Chen-Han Peng, Chen-Ying Lu, Xing-Yao Cheng, Xiang-Chao Luo, Jie Li, Jing Qi, Xu-Qi Kang, Fei-Yang Jin, Min-Jiang Chen, Xiao-Ying Ying, Jian You, Yong-Zhong Du, Jian-Song Ji. (2019) Combinational protective therapy for spinal cord injury medicated by sialic acid-driven and polyethylene glycol based micelles. BIOMATERIALS, 217 (119326). [PMID:31288173] [10.1016/j.biomaterials.2019.119326]
11. Yi Quan, Tan Fang-hui, Tan Jia-an, Chen Xiu-hui, Xiao Qing, Liu Ying-hua, Zhang Gui-ping, Luo Jian-dong. (2019) Minocycline protects against myocardial ischemia/reperfusion injury in rats by upregulating MCPIP1 to inhibit NF-κB activation. ACTA PHARMACOLOGICA SINICA, 40 (8): (1019-1028). [PMID:30792486] [10.1038/s41401-019-0214-z]

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