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Minocycline hydrochloride - 2mM in Water, high purity , CAS No.13614-98-7

10 Citations
  • 2mM in Water
Item Number
M421372
Grouped product items
SKUSizeAvailabilityPrice Qty
M421372-1ml
1ml
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$69.90
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Antibiotic. Demonstrates multiple effects.

Basic Description

SynonymsMINOCYCLINE HYDROCHLORIDE | 13614-98-7 | Minocycline HCl | Arestin | Solodyn | Minomycin | Minocin | Dynacin | Periocline | Ximino | Minocycline (hydrochloride) | Vectrin | Minomax | (4S,4aS,5aR,12aS)-4,7-bis(dimethylamino)-3,10,12,12a-tetrahydroxy-1,11-dioxo-1,4,4a,5,5a,6,11,12a-
Specifications & Purity2mM in Water
Biochemical and Physiological MechanismsMinocycline is a tetracycline antibiotic with neuroprotective, antiapoptotic, anti-inflammatory and antimicrobial effects. Minocycline acts as a matrix metalloproteinase (MMP) inhibitor; attenuates disease severity in mouse models of multiple sclerosis. M
Storage TempStore at -80°C
Shipped InIce chest + Ice pads
Product Description

Minocycline hydrochloride has been used: · to prepare nanoliposomes to check its effect on macrophages · for the inhibition of neuroinflammation and neuropathic pain · to treat glioma in murine GL261 glioma cells

Names and Identifiers

IUPAC Name (4S,4aS,5aR,12aR)-4,7-bis(dimethylamino)-1,10,11,12a-tetrahydroxy-3,12-dioxo-4a,5,5a,6-tetrahydro-4H-tetracene-2-carboxamide;hydrochloride
INCHI InChI=1S/C23H27N3O7.ClH/c1-25(2)12-5-6-13(27)15-10(12)7-9-8-11-17(26(3)4)19(29)16(22(24)32)21(31)23(11,33)20(30)14(9)18(15)28;/h5-6,9,11,17,27-28,31,33H,7-8H2,1-4H3,(H2,24,32);1H/t9-,11-,17-,23-;/m0./s1
InChi Key WTJXVDPDEQKTCV-VQAITOIOSA-N
Canonical SMILES CN(C)C1C2CC3CC4=C(C=CC(=C4C(=C3C(=O)C2(C(=C(C1=O)C(=O)N)O)O)O)O)N(C)C.Cl
Isomeric SMILES CN(C)[C@H]1[C@@H]2C[C@@H]3CC4=C(C=CC(=C4C(=C3C(=O)[C@@]2(C(=C(C1=O)C(=O)N)O)O)O)O)N(C)C.Cl
WGK Germany 3
RTECS QI7630500
PubChem CID 54685925
Molecular Weight 493.94
Reaxy-Rn 4836328

Certificates

Certificate of Analysis(COA)

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Chemical and Physical Properties

SensitivityHeat sensitive
Specific Rotation[α]-170 to -180 deg(C=0.5、0.1mol/L HCl)
Flash Point(°F)230°F
Flash Point(°C)>110℃
Boil Point(°C)813℃
Melt Point(°C)205-210℃

Safety and Hazards(GHS)

Pictogram(s) GHS07
Signal Warning
Hazard Statements

H315:Causes skin irritation

H319:Causes serious eye irritation

H335:May cause respiratory irritation

H362:May cause harm to breast-fed children

Precautionary Statements

P261:Avoid breathing dust/fume/gas/mist/vapors/spray.

P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing.

P280:Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352:IF ON SKIN: wash with plenty of water.

P321:Specific treatment (see ... on this label).

P405:Store locked up.

P501:Dispose of contents/container to ...

P264:Wash hands [and …] thoroughly after handling.

P260:Do not breathe dust/fume/gas/mist/vapors/spray.

P271:Use only outdoors or in a well-ventilated area.

P270:Do not eat, drink or smoke when using this product.

P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing.

P403+P233:Store in a well-ventilated place. Keep container tightly closed.

P362+P364:Take off contaminated clothing and wash it before reuse.

P263:Avoid contact during pregnancy/while nursing.

P203:Obtain, read and follow all safety instructions before use.

P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes.

P318:if exposed or concerned, get medical advice.

P337+P317:If eye irritation persists: Get medical help.

P332+P317:If skin irritation occurs: Get medical help.

P319:Get medical help if you feel unwell.

WGK Germany 3
RTECS QI7630500
Reaxy-Rn 4836328
Merck Index 6202

Related Documents

 SDS

 Specification Sheet

Citations of This Product

How to Cite Aladdin Scientific Products?
1. Ting Zhu, Jinyang Chen, Shasha Zeng, Jintao Chen, Chunjiao Qi.  (2023)  Highly Stable Fluorescent-Traffic-Light Sensor for Point-of-Care Detection of Tetracycline.  ACS Sensors,  8  (11): (4272–4280).  [PMID:37862265] [10.1021/acssensors.3c01620]
2. Fei Tong, Pei Wang, Ziqiang Chen, Yifan Liu, Lianguo Wang, Jun Guo, Zhihua Li, Hu Cai, Junchao Wei.  (2023)  Combined Ferromagnetic Nanoparticles for Effective Periodontal Biofilm Eradication in Rat Model.  International Journal of Nanomedicine,      [PMID:37192894] [10.2147/IJN.S402410]
3. Keke Huang, Xin Liu, Ziru Lv, Di Zhang, Yuling Zhou, Zhiqing Lin, Juan Guo.  (2023)  MMP9-Responsive Graphene Oxide Quantum Dot-Based Nano-in-Micro Drug Delivery System for Combinatorial Therapy of Choroidal Neovascularization.  Small,    (2207335).  [PMID:36871144] [10.1002/smll.202207335]
4. Jinyu An, Xue Jiang, Zhe Wang, Yingqiao Li, Zhiru Zou, Qian Wu, Le Tong, Xifan Mei, He Tian, Chao Wu.  (2022)  Codelivery of minocycline hydrochloride and dextran sulfate via bionic liposomes for the treatment of spinal cord injury.  INTERNATIONAL JOURNAL OF PHARMACEUTICS,  628  (122285).  [PMID:36244559] [10.1016/j.ijpharm.2022.122285]
5. Ling Yang, Jing Yang, Hua Liu, Jingbin Lan, Ying Xu, Xiaobo Wu, Yushan Mao, Dongming Wu, Kejian Pan, Tao Zhang.  (2022)  Minocycline binds and inhibits LYN activity to prevent STAT3-meditated metastasis of colorectal cancer.  International Journal of Biological Sciences,  18  (6): ( 2540–2552).  [PMID:35414768] [10.7150/ijbs.70708]
6. Yule Wang, Huimin Wu, Zhu Han, Hongda Sheng, Yuhan Wu, Yingchao Wang, Xinran Guo, Yan Zhu, Xuecai Li, Yi Wang.  (2022)  Guhong injection promotes post-stroke functional recovery via attenuating cortical inflammation and apoptosis in subacute stage of ischemic stroke.  PHYTOMEDICINE,  99  (154034).  [PMID:35276592] [10.1016/j.phymed.2022.154034]
7. Chengzhi Zhou, Yanlong Sun, Fan Zhang, Yuandong Wu.  (2021)  Degradation of Minocycline by the Adsorption–Catalysis Multifunctional PVDF–PVP–TiO2 Membrane: Degradation Kinetics, Photocatalytic Efficiency, and Toxicity of Products.  International Journal of Environmental Research and Public Health,  18  (23): (12339).  [PMID:34886061] [10.3390/ijerph182312339]
8. Lijuan Yang, Jing Zeng, Tian Quan, Shaochi Liu, Linlin Deng, Xun Kang, Zhining Xia, Die Gao.  (2021)  Liquid-liquid extraction and purification of oil red O derived nitrogen-doped highly photoluminescent carbon dots and their application as multi-functional sensing platform for Cu2+ and tetracycline antibiotics.  MICROCHEMICAL JOURNAL,  168  (106391).  [PMID:] [10.1016/j.microc.2021.106391]
9. Xiao-Juan Wang, Gao-Feng Shu, Xiao-Ling Xu, Chen-Han Peng, Chen-Ying Lu, Xing-Yao Cheng, Xiang-Chao Luo, Jie Li, Jing Qi, Xu-Qi Kang, Fei-Yang Jin, Min-Jiang Chen, Xiao-Ying Ying, Jian You, Yong-Zhong Du, Jian-Song Ji.  (2019)  Combinational protective therapy for spinal cord injury medicated by sialic acid-driven and polyethylene glycol based micelles.  BIOMATERIALS,  217  (119326).  [PMID:31288173] [10.1016/j.biomaterials.2019.119326]
10. Yi Quan, Tan Fang-hui, Tan Jia-an, Chen Xiu-hui, Xiao Qing, Liu Ying-hua, Zhang Gui-ping, Luo Jian-dong.  (2019)  Minocycline protects against myocardial ischemia/reperfusion injury in rats by upregulating MCPIP1 to inhibit NF-κB activation.  ACTA PHARMACOLOGICA SINICA,  40  (8): (1019-1028).  [PMID:30792486] [10.1038/s41401-019-0214-z]

References

1. Ting Zhu, Jinyang Chen, Shasha Zeng, Jintao Chen, Chunjiao Qi.  (2023)  Highly Stable Fluorescent-Traffic-Light Sensor for Point-of-Care Detection of Tetracycline.  ACS Sensors,  8  (11): (4272–4280).  [PMID:37862265] [10.1021/acssensors.3c01620]
2. Fei Tong, Pei Wang, Ziqiang Chen, Yifan Liu, Lianguo Wang, Jun Guo, Zhihua Li, Hu Cai, Junchao Wei.  (2023)  Combined Ferromagnetic Nanoparticles for Effective Periodontal Biofilm Eradication in Rat Model.  International Journal of Nanomedicine,      [PMID:37192894] [10.2147/IJN.S402410]
3. Keke Huang, Xin Liu, Ziru Lv, Di Zhang, Yuling Zhou, Zhiqing Lin, Juan Guo.  (2023)  MMP9-Responsive Graphene Oxide Quantum Dot-Based Nano-in-Micro Drug Delivery System for Combinatorial Therapy of Choroidal Neovascularization.  Small,    (2207335).  [PMID:36871144] [10.1002/smll.202207335]
4. Jinyu An, Xue Jiang, Zhe Wang, Yingqiao Li, Zhiru Zou, Qian Wu, Le Tong, Xifan Mei, He Tian, Chao Wu.  (2022)  Codelivery of minocycline hydrochloride and dextran sulfate via bionic liposomes for the treatment of spinal cord injury.  INTERNATIONAL JOURNAL OF PHARMACEUTICS,  628  (122285).  [PMID:36244559] [10.1016/j.ijpharm.2022.122285]
5. Ling Yang, Jing Yang, Hua Liu, Jingbin Lan, Ying Xu, Xiaobo Wu, Yushan Mao, Dongming Wu, Kejian Pan, Tao Zhang.  (2022)  Minocycline binds and inhibits LYN activity to prevent STAT3-meditated metastasis of colorectal cancer.  International Journal of Biological Sciences,  18  (6): ( 2540–2552).  [PMID:35414768] [10.7150/ijbs.70708]
6. Yule Wang, Huimin Wu, Zhu Han, Hongda Sheng, Yuhan Wu, Yingchao Wang, Xinran Guo, Yan Zhu, Xuecai Li, Yi Wang.  (2022)  Guhong injection promotes post-stroke functional recovery via attenuating cortical inflammation and apoptosis in subacute stage of ischemic stroke.  PHYTOMEDICINE,  99  (154034).  [PMID:35276592] [10.1016/j.phymed.2022.154034]
7. Chengzhi Zhou, Yanlong Sun, Fan Zhang, Yuandong Wu.  (2021)  Degradation of Minocycline by the Adsorption–Catalysis Multifunctional PVDF–PVP–TiO2 Membrane: Degradation Kinetics, Photocatalytic Efficiency, and Toxicity of Products.  International Journal of Environmental Research and Public Health,  18  (23): (12339).  [PMID:34886061] [10.3390/ijerph182312339]
8. Lijuan Yang, Jing Zeng, Tian Quan, Shaochi Liu, Linlin Deng, Xun Kang, Zhining Xia, Die Gao.  (2021)  Liquid-liquid extraction and purification of oil red O derived nitrogen-doped highly photoluminescent carbon dots and their application as multi-functional sensing platform for Cu2+ and tetracycline antibiotics.  MICROCHEMICAL JOURNAL,  168  (106391).  [PMID:] [10.1016/j.microc.2021.106391]
9. Xiao-Juan Wang, Gao-Feng Shu, Xiao-Ling Xu, Chen-Han Peng, Chen-Ying Lu, Xing-Yao Cheng, Xiang-Chao Luo, Jie Li, Jing Qi, Xu-Qi Kang, Fei-Yang Jin, Min-Jiang Chen, Xiao-Ying Ying, Jian You, Yong-Zhong Du, Jian-Song Ji.  (2019)  Combinational protective therapy for spinal cord injury medicated by sialic acid-driven and polyethylene glycol based micelles.  BIOMATERIALS,  217  (119326).  [PMID:31288173] [10.1016/j.biomaterials.2019.119326]
10. Yi Quan, Tan Fang-hui, Tan Jia-an, Chen Xiu-hui, Xiao Qing, Liu Ying-hua, Zhang Gui-ping, Luo Jian-dong.  (2019)  Minocycline protects against myocardial ischemia/reperfusion injury in rats by upregulating MCPIP1 to inhibit NF-κB activation.  ACTA PHARMACOLOGICA SINICA,  40  (8): (1019-1028).  [PMID:30792486] [10.1038/s41401-019-0214-z]

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