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Minoxidil - >98.0%(HPLC)(T), high purity , CAS No.38304-91-5, Activator of K ir6.1;Activator of K ir6.2

Moligand™
≥98%(HPLC)(T)

CAS#: 38304-91-5
Formula: C₉H₁₅N₅O
Molecular Weight: 209.25
Beilstein Registry Number: 25(5)12,317
MDL number: MFCD00063409
PubChem CID: 4201
PubChem SID: 488179821

Item Number

M158689

Grouped product items
SKU	Size	Availability	Price
M158689-1g	1g	In stock	$29.90
M158689-5g	5g	In stock	$87.90
M158689-25g	25g	In stock	$299.90
M158689-100g	100g	In stock	$799.90

Kir6 channel (KATP) opener

View related series

Antihypertensive Ingredients Kir6.1 Activator Kir6.2 Activator Pharmaceutical ingredients

Basic Description

Synonyms	minoxidil\|38304-91-5\|Rogaine\|Loniten\|Minoximen\|Regaine\|Theroxidil\|Alopexil\|Alostil\|Tricoxidil\|Lonolox\|Normoxidil\|Prexidil\|Minodyl\|Pierminox\|RiUP\|Mintop\|2,4-Pyrimidinediamine, 6-(1-piperidinyl)-, 3-oxide\|U-10858\|6-(1-Piperidinyl)-2,4-pyrimidinediamine 3-ox
Specifications & Purity	>98.0%(HPLC)(T)
Shipped In	Normal
Grade	Moligand™
Action Type	ACTIVATOR
Mechanism of action	Activator of K ir6.1;Activator of K ir6.2
Product Description	Minoxidil is used as antihypertensive, antialopecia agent. . It is administered orally for the treatment of severe hypertension and used topically to promote the regrowth of hair in male and female pattern baldness.

Associated Targets

KCNJ8 Tbio ATP-sensitive inward rectifier potassium channel 8 0 Activities

Discover Target: KCNJ8

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

KCNJ11 Tclin ATP-sensitive inward rectifier potassium channel 11 0 Activities

Discover Target: KCNJ11

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

Pubchem Sid	488179821
Pubchem Sid Url	https://pubchem.ncbi.nlm.nih.gov/substance/488179821
IUPAC Name	3-hydroxy-2-imino-6-piperidin-1-ylpyrimidin-4-amine
INCHI	InChI=1S/C9H15N5O/c10-7-6-8(12-9(11)14(7)15)13-4-2-1-3-5-13/h6,11,15H,1-5,10H2
InChi Key	ZIMGGGWCDYVHOY-UHFFFAOYSA-N
Canonical SMILES	C1CCN(CC1)C2=NC(=N)N(C(=C2)N)O
Isomeric SMILES	C1CCN(CC1)C2=NC(=N)N(C(=C2)N)O
WGK Germany	3
RTECS	UV8200000
PubChem CID	4201
Molecular Weight	209.25
Beilstein	25(5)12,317
Reaxy-Rn	886240

Database links

DrugBank Ligand	DB00350
Wikipedia	Minoxidil
CAS Registry No.	38304-91-5
ChEMBL Ligand	CHEMBL802
PubChem CID	4201
RCSB PDB Ligand	MXD
PEP	minoxidil
DrugCentral Ligand	1814
PubChem SID	488179821

Certificates

Certificate of Analysis(COA)

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16 results found

Lot Number	Certificate Type	Date	Item
D2412273	Certificate of Analysis	Mar 15, 2024	M158689
D2412270	Certificate of Analysis	Mar 15, 2024	M158689
D2412275	Certificate of Analysis	Mar 15, 2024	M158689
A2429160	Certificate of Analysis	Jan 18, 2024	M158689
A2429161	Certificate of Analysis	Jan 18, 2024	M158689
A2429163	Certificate of Analysis	Jan 18, 2024	M158689
A2429164	Certificate of Analysis	Jan 18, 2024	M158689
G2310375	Certificate of Analysis	Feb 01, 2023	M158689
G2310377	Certificate of Analysis	Feb 01, 2023	M158689
G2310408	Certificate of Analysis	Feb 01, 2023	M158689
G2310409	Certificate of Analysis	Feb 01, 2023	M158689
G2310411	Certificate of Analysis	Feb 01, 2023	M158689
G2310432	Certificate of Analysis	Feb 01, 2023	M158689
G2310440	Certificate of Analysis	Feb 01, 2023	M158689
C1805044	Certificate of Analysis	Jan 22, 2022	M158689
B2315640	Certificate of Analysis	Nov 22, 2021	M158689

Chemical and Physical Properties

Solubility	Solvent:ethanol, Max Conc. mg/mL: 5.23, Max Conc. mM: 25; Solvent:DMSO, Max Conc. mg/mL: 5.23, Max Conc. mM: 25 with gentle warming
Melt Point(°C)	272-274 °C

Safety and Hazards(GHS)

Pictogram(s)	GHS08, GHS07
Signal	Warning
Hazard Statements	H315:Causes skin irritation H319:Causes serious eye irritation H335:May cause respiratory irritation H351:Suspected of causing cancer H302:Harmful if swallowed H361:Suspected of damaging fertility or the unborn child
Precautionary Statements	P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P271:Use only outdoors or in a well-ventilated area. P270:Do not eat, drink or smoke when using this product. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P362+P364:Take off contaminated clothing and wash it before reuse. P330:Rinse mouth. P203:Obtain, read and follow all safety instructions before use. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P301+P317:IF SWALLOWED: Get medical help. P318:if exposed or concerned, get medical advice. P337+P317:If eye irritation persists: Get medical help. P332+P317:If skin irritation occurs: Get medical help. P319:Get medical help if you feel unwell.
WGK Germany	3
RTECS	UV8200000
Reaxy-Rn	886240
Merck Index	6203

References

1. Yushu Chen a , Shouwen Jin a,* , Yutao Chen a , Xingjun Gao a,* , Xusen Gong a , Linfang Shi b , Hui Liu a , Xiaodan Ma a,b , Daqi Wang c. (2024) 2D-3D supramolecular systems assemblied from minoxidil and organic acids: Preparation, spectral, crystallographic characterization and Hirshfeld surface analysis . Journal of Molecular Structure, 1302 (1302): (137353). [PMID:]

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