miricorilant , CAS No.M611890, Antagonist of Glucocorticoid receptor

Item Number

M611890

Grouped product items
SKU	Size	Availability	Price	Qty
M611890-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,300.90
M611890-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$2,000.90

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Basic Description

Synonyms	Miricorilant\|CORT118335\|Miricorilant [INN]\|Miricorilant [USAN]\|CORT-118335\|311Y5GV21M\|Miricorilant [USAN:INN]\|UNII-311Y5GV21M\|1400902-13-7\|CHEMBL2204043\|WHO 10853\|6-(trans-4-Phenylcyclohexyl)-5-((3-(trifluoromethyl)phenyl)methyl)-2,4(1H,3H)-pyrimidinedion
Grade	Moligand™
Action Type	ANTAGONIST
Mechanism of action	Antagonist of Glucocorticoid receptor

Names and Identifiers

IUPAC Name	6-(trans-4-phenylcyclohexyl)-5-{[3-(trifluoromethyl)phenyl]methyl}pyrimidine-2,4(1H,3H)-dione
INCHI	InChI=1S/C24H23F3N2O2/c25-24(26,27)19-8-4-5-15(13-19)14-20-21(28-23(31)29-22(20)30)18-11-9-17(10-12-18)16-6-2-1-3-7-16/h1-8,13,17-18H,9-12,14H2,(H2,28,29,30,31)/t17-,18-
InChi Key	GVVUZBSCYAVFTI-IYARVYRRSA-N
Canonical SMILES	O=c1[nH]c(=O)c(c([nH]1)[C@@H]1CC[C@H](CC1)c1ccccc1)Cc1cccc(c1)C(F)(F)F
Isomeric SMILES	C1CC(CCC1C2=CC=CC=C2)C3=C(C(=O)NC(=O)N3)CC4=CC(=CC=C4)C(F)(F)F
PubChem CID	66550324

References

1. Gross C, Blasey CM, Roe RL, Belanoff JK. (2010) Mifepristone reduces weight gain and improves metabolic abnormalities associated with risperidone treatment in normal men.. Obesity (Silver Spring), 18 (12): (2295-300). [PMID:20339369]
2. Hunt HJ, Ray NC, Hynd G, Sutton J, Sajad M, O'Connor E, Ahmed S, Lockey P, Daly S, Buckley G et al.. (2012) Discovery of a novel non-steroidal GR antagonist with in vivo efficacy in the olanzapine-induced weight gain model in the rat.. Bioorg Med Chem Lett, 22 (24): (7376-80). [PMID:23131342]

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Basic Description