Mirogabalin besylate - 99%, high purity , Voltage-gated calcium channel alpha2/delta subunit 2 modulator, CAS No.1138245-21-2, Voltage-gated calcium channel alpha2/delta subunit 2 modulator

Item Number

M650071

Grouped product items
SKU	Size	Availability	Price
M650071-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$66.90
M650071-10mg	10mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$104.90
M650071-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$172.90
M650071-50mg	50mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$294.90
M650071-100mg	100mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$475.90

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Basic Description

Synonyms	Mirogabalin besylate \| A901402 \| Mirogabalin besilate [WHO-DD] \| Mirogabalin Besylate (USAN) \| AC-30336 \| 01F4FRP8YL \| 2-[(1R,5S,6S)-6-(aminomethyl)-3-ethylbicyclo[3.2.0]hept-3-en-6-yl]acetic acid; benzenesulfonic acid \| EX-A2817 \| DS 5565 besylate
Specifications & Purity	≥99%
Biochemical and Physiological Mechanisms	Mirogabalin besylate is a selective and orally available ligand for the α2δ subunit of voltage-gated calcium channels , with K d s of 13.5 nM, 22.7 nM, 27 nM, and 47.6 nM for human α2δ-1, human α2δ-2, rat α2δ-1, and rat α2δ-2, respectively.
Storage Temp	Store at -20°C,Desiccated
Shipped In	Ice chest + Ice pads
Action Type	MODULATOR
Mechanism of action	Voltage-gated calcium channel alpha2/delta subunit 2 modulator
Product Description	Mirogabalin besylate is a selective ligand for the α2δ subunit of voltage-gated calcium channels, with Kds of 13.5 nM, 22.7 nM, 27 nM, and 47.6 nM for human α2δ-1, human α2δ-2, rat α2δ-1, and rat α2δ-2, respectively.

Names and Identifiers

IUPAC Name	2-[(1R,5S,6S)-6-(aminomethyl)-3-ethyl-6-bicyclo[3.2.0]hept-3-enyl]acetic acid;benzenesulfonic acid
INCHI	InChI=1S/C12H19NO2.C6H6O3S/c1-2-8-3-9-5-12(7-13,6-11(14)15)10(9)4-8;7-10(8,9)6-4-2-1-3-5-6/h4,9-10H,2-3,5-7,13H2,1H3,(H,14,15);1-5H,(H,7,8,9)/t9-,10-,12-;/m1./s1
InChi Key	OKJXJRVWXYRSAN-TXULWXBWSA-N
Canonical SMILES	CCC1=C[C@@H]2[C@H](C1)C[C@@]2(CC(=O)O)CN.C1=CC=C(C=C1)S(=O)(=O)O
Isomeric SMILES	CCC1=C[C@@H]2[C@H](C1)C[C@@]2(CC(=O)O)CN.C1=CC=C(C=C1)S(=O)(=O)O
PubChem CID	81689826
Molecular Weight	367.46

Certificates

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5 results found

Lot Number	Certificate Type	Date	Item
H2419201	Certificate of Analysis	May 08, 2024	M650071
H2419202	Certificate of Analysis	May 08, 2024	M650071
H2419203	Certificate of Analysis	May 08, 2024	M650071
H2419204	Certificate of Analysis	May 08, 2024	M650071
H2419235	Certificate of Analysis	May 08, 2024	M650071

Solubility

DMSO : 125 mg/mL (340.17 mM; Need ultrasonic)

Sensitivity

Moisture sensitive

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Basic Description