Purity>95% (SDS-PAGE&SEC); Endotoxin Level < 0.01EU/μg; Human IgG1; CHO; ELISA, FACS, Functional assay, Animal Model; Unconjugated
| SKU | Size | Availability | Price | Qty |
|---|---|---|---|---|
| Ab182809-100μg | 100μg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $69.90 | |
| Ab182809-1mg | 1mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $349.90 | |
| Ab182809-5mg | 5mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $899.90 | |
| Ab182809-10mg | 10mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $1,439.90 |
Purity>95% (SDS-PAGE&SEC); Endotoxin Level < 0.01EU/μg; Human IgG1; CHO; ELISA, FACS, Functional assay, Animal Model; Unconjugated
| Product Name | Mitazalimab (anti-CD40) - Primary antibody, specific to CD40, Human IgG1 |
|---|---|
| Specifications & Purity | Carrier Free, Recombinant, ExactAb™, Low Endotoxin, Azide Free, Validated, ≥95%(SDS-PAGE&SEC), Lot by Lot |
| Specificity | CD40 |
| Conjugation | Unconjugated |
| Grade | Azide Free, Carrier Free, ExactAb™, Low Endotoxin, Recombinant, Validated |
| Product Description | Mitazalimab (anti-CD40) is FcγR-dependent CD40 agonist with tumor-directed activity. Mitazalimab (anti-CD40) activates antigen-presenting cells, e.g. dendritic cells (DC), to initiate tumor-reactive T cells. Therefore, Mitazalimab (anti-CD40) induces tumor-specific T cells to infiltrate and kill tumors. Mitazalimab (anti-CD40) remodels the tumor-infiltrating myeloid microenvironment. |
| Isotype | Human IgG1 |
|---|---|
| Light Chain Type | lambda |
| SDS-PAGE | 143.44 kDa |
| Purification Method | Protein A purified |
| Form | Liquid |
| Concentration | Lot by Lot |
| Storage Temp | Store at -80°C,Avoid repeated freezing and thawing |
| Shipped In | Ice chest + Ice pads |
| Stability And Storage | Store at -80℃ for 24 months. Upon delivery aliquot. Avoid freeze/thaw cycle. |
| CAS | 2055640-86-1 |
Mitazalimab (anti-CD40) (Ab182809) - Flow Cytometry
Flow Cytometry analysis of Raji cells labelling CD40 (red) with Mitazalimab (anti-CD40) (Ab182809). Goat Anti-Human IgG (PE) (Ab175838) at a dilution of 1/1000 was used as the secondary antibody. Blue - Isotype control, human IgG (Ab170213). Black - Unlabelled control, cells without incubation with primary antibody.
Mitazalimab (anti-CD40) (Ab182809) - Flow Cytometry
Flow Cytometry analysis of U2OS cells labelling CD40 (red) with Mitazalimab (anti-CD40) (Ab182809). Goat Anti-Human IgG (PE) (Ab175838) at a dilution of 1/1000 was used as the secondary antibody. Blue - Isotype control, human IgG (Ab170213). Black - Unlabelled control, cells without incubation with primary antibody.
Mitazalimab (anti-CD40) (Ab182809) - ELISA
Immobilized Recombinant Human CD40 protein (rp183577) at 1.0 μg/mL can bind Mitazalimab (anti-CD40) (Ab182809) with the EC50 of 4.37 ng/mL.
Mitazalimab (anti-CD40) (Ab182809) - SEC
The purity of Mitazalimab (anti-CD40) (Ab182809) is more than 95% verified by HPLC.
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
|---|
Enter Lot Number to search for COA:
To view the certificate results,please click on a Lot number.For Lot numbers from past orders,please use our order status section
| Lot Number | Certificate Type | Date | Item |
|---|---|---|---|
 ZJ24F0708322 | Certificate of Analysis | Jul 16, 2024 | Ab182809 |
| ZJ24F0708321 | Certificate of Analysis | Jul 16, 2024 | Ab182809 |
| ZJ24F0708320 | Certificate of Analysis | Jul 16, 2024 | Ab182809 |
