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mitoglitazone , CAS No.M611896, Inhibitor of mitochondrial pyruvate carrier 1;Inhibitor of mitochondrial pyruvate carrier 2

Moligand™

PubChem CID: 10429242

Item Number

M611896

Grouped product items
SKU	Size	Availability	Price	Qty
M611896-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,300.90
M611896-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$2,000.90

View related series

mitochondrial pyruvate carrier 1 Inhibitor mitochondrial pyruvate carrier 2 Inhibitor

Basic Description

Synonyms	Mitoglitazone\|146062-49-9\|MSDC-0160\|CAY10415\|5-(4-(2-(5-ethylpyridin-2-yl)-2-oxoethoxy)benzyl)thiazolidine-2,4-dione\|MSDC 0160\|CAY 10415\|CAY-10415\|MSD-9\|29I7RP18RG\|MSDC0160\|U-91325\|5-(4-(2-(5-Ethylpyridin-2-yl)-2-oxoethoxy)-benzyl)thiazolidine-2,4-dione\|P
Specifications & Purity	Moligand™
Grade	Moligand™
Action Type	INHIBITOR
Mechanism of action	Inhibitor of mitochondrial pyruvate carrier 1;Inhibitor of mitochondrial pyruvate carrier 2

Associated Targets

CYP2C8 Tchem Cytochrome P450 2C8 0 Activities

Discover Target: CYP2C8

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CYP2C9 Tchem Cytochrome P450 2C9 0 Activities

Discover Target: CYP2C9

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

MPC2 Tbio Mitochondrial pyruvate carrier 2 0 Activities

Discover Target: MPC2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

KCNH2 Tclin Potassium voltage-gated channel subfamily H member 2 0 Activities

Discover Target: KCNH2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

PPARG Tclin Peroxisome proliferator-activated receptor gamma 0 Activities

Discover Target: PPARG

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

MPC1 Tbio Mitochondrial pyruvate carrier 1 0 Activities

Discover Target: MPC1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

IUPAC Name	5-[[4-[2-(5-ethylpyridin-2-yl)-2-oxoethoxy]phenyl]methyl]-1,3-thiazolidine-2,4-dione
INCHI	InChI=1S/C19H18N2O4S/c1-2-12-5-8-15(20-10-12)16(22)11-25-14-6-3-13(4-7-14)9-17-18(23)21-19(24)26-17/h3-8,10,17H,2,9,11H2,1H3,(H,21,23,24)
InChi Key	IRNJSRAGRIZIHD-UHFFFAOYSA-N
Canonical SMILES	CCc1ccc(nc1)C(=O)COc1ccc(cc1)CC1SC(=O)NC1=O
Isomeric SMILES	CCC1=CN=C(C=C1)C(=O)COC2=CC=C(C=C2)CC3C(=O)NC(=O)S3
PubChem CID	10429242

PubChem CID

ChEMBL Ligand

BindingDB Ligand

DrugBank Ligand

References

1. Divakaruni AS, Wiley SE, Rogers GW, Andreyev AY, Petrosyan S, Loviscach M, Wall EA, Yadava N, Heuck AP, Ferrick DA et al.. (2013) Thiazolidinediones are acute, specific inhibitors of the mitochondrial pyruvate carrier.. Proc Natl Acad Sci U S A, 110 (14): (5422-7). [PMID:23513224]
2. Shah RC, Matthews DC, Andrews RD, Capuano AW, Fleischman DA, VanderLugt JT, Colca JR. (2014) An evaluation of MSDC-0160, a prototype mTOT modulating insulin sensitizer, in patients with mild Alzheimer's disease.. Curr Alzheimer Res, 11 (6): (564-73). [PMID:24931567]
3. Tanis SP, Parker TT, Colca JR, Fisher RM, Kletzein RF. (1996) Synthesis and biological activity of metabolites of the antidiabetic, antihyperglycemic agent pioglitazone.. J Med Chem, 39 (26): (5053-63). [PMID:8978836]

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