| SKU | Size | Availability | Price | Qty |
|---|---|---|---|---|
| M407788-1ml | 1ml | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $293.90 |
ADC Cytotoxin
| Synonyms | mitomycin C | Mitomycin | 50-07-7 | Ametycine | Mutamycin | Mitomycin-C | Mitocin-C | Ametycin | Mytozytrex | Mitomycinum | Mytomycin | Mitomycinum C | Mitamycin | Mitozytrex | Mitosol | Muamycin | Mitomycyna C | 7-Amino-9alpha-methoxymitosane | MMC | Mito-C | NSC-26980 | Mit-C | RCRA waste number |
|---|---|
| Specifications & Purity | 10mM in DMSO |
| Storage Temp | Store at -80°C |
| Shipped In | Ice chest + Ice pads |
| Product Description | Information Mitomycin C is an antineoplastic antibiotic by inhibiting DNA synthesis, used to treat different cancers. Mitomycin C induces apoptosis in a caspases-dependent and Fas/CD95-independent manner. Mitomycin C, by inducing DNA interstrand crosslinks, physically blocks DNA replication, recombination, and RNA transcription. [1] Mitomycin C potentiates TRAIL-induced apoptosis in HCT116 (p53-/-) colon cancer cells and sensitizes TRAIL-resistant colon cancer cells HT-29 to the cytokine by through JNK-independent upregulation of death receptors. [2] In different human cancer cell lines, such OVCAR-5 (ovary), HT-29 (colon), SK-N-MC (neuroblastoma), HEP-2 (liver), COLO-205 (colon), NIH-OVCAR-3 (ovary) and A-549 (lung) cells, Mitomycin C shows cytotoxic activity. In vivo As the clinical first choice in superficial bladder tumors, in a rat bladder tumor model, Mitomycin C (400 μM) significantly prevents intravesical tumor growth. cell lines： Concentrations： Incubation Time： Powder Purity:≥97% |
| Canonical SMILES | COC12C(COC(N)=O)C3=C(N1CC4NC24)C(=O)C(=C(N)C3=O)C |
|---|---|
| Molecular Weight | 334.37 |
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| Solubility | Solubility (25°C) In vitro Water: 97 mg/mL (200.25 mM); DMSO: Insoluble; Ethanol: Insoluble; |
|---|---|
| Sensitivity | Light & Heat & Moisture sensitive |
