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MitoPQ - ≥98%, high purity , CAS No.1821370-28-8

  • ≥98%
Item Number
M275666
Grouped product items
SKUSizeAvailabilityPrice Qty
M275666-5mg
5mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$99.90
M275666-10mg
10mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$119.90
M275666-25mg
25mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$229.90
M275666-50mg
50mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$395.90
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Selective, mitochondria-targeted redox cycler

View related series
ROS Kinase

Basic Description

Synonyms1-Methyl-1'-[10''-(triphenylphosphonio)dec-1''-yl]-4,4'-bipyridine-1-1'-diiumtriiodide
Specifications & Purity≥98%
Biochemical and Physiological MechanismsSelective, mitochondria-targeted redox cycler. Selectively increases superoxide production within the mitochondrial matrix in vitro and in vivo . Comprises a triphenylphosphonium lipophilic cation conjugated to the redox cycler paraquat.
Storage TempStore at 2-8°C,Argon charged,Desiccated
Shipped InWet ice
NoteWherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description

MitoPQ is a mitochondria-targeted redox cycler. MitoPQ produces superoxide by redox cycling at the flavin site of complex I, selectively increasing superoxide production within mitochondria. MitoPQ can be used in antioxidant study.

Names and Identifiers

IUPAC Name 10-[4-(1-methylpyridin-1-ium-4-yl)pyridin-1-ium-1-yl]decyl-triphenylphosphanium;triiodide
INCHI InChI=1S/C39H46N2P.3HI/c1-40-30-25-35(26-31-40)36-27-32-41(33-28-36)29-17-6-4-2-3-5-7-18-34-42(37-19-11-8-12-20-37,38-21-13-9-14-22-38)39-23-15-10-16-24-39;;;/h8-16,19-28,30-33H,2-7,17-18,29,34H2,1H3;3*1H/q+3;;;/p-3
InChi Key AOZZGHKENAZYTD-UHFFFAOYSA-K
Canonical SMILES C[N+]1=CC=C(C=C1)C2=CC=[N+](C=C2)CCCCCCCCCC[P+](C3=CC=CC=C3)(C4=CC=CC=C4)C5=CC=CC=C5.[I-].[I-].[I-]
Isomeric SMILES C[N+]1=CC=C(C=C1)C2=CC=[N+](C=C2)CCCCCCCCCC[P+](C3=CC=CC=C3)(C4=CC=CC=C4)C5=CC=CC=C5.[I-].[I-].[I-]
PubChem CID 129909777
Molecular Weight 954.48

Certificates

Certificate of Analysis(COA)

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Chemical and Physical Properties

SolubilitySoluble in ethanol to 10 mM and in DMSO to 100 mM
SensitivityMoisture sensitive.

Related Documents

 SDS

 Specification Sheet

References

1. Arias-Mayenco I et al..  (2018)  Acute O2 Sensing: Role of Coenzyme QH2/Q Ratio and Mitochondrial ROS Compartmentalization..  Cell Metab,  28  (145-158.e4).  [PMID:29887397]
2. Gonzalez-Menendez P et al..  (2021)  An IDH1-vitamin C crosstalk drives human erythroid development by inhibiting pro-oxidant mitochondrial metabolism..  Cell Rep,  34  (5): (108723).  [PMID:33535038]
3. Jimenez-Duran G et al..  (2022)  Complement membrane attack complex is an immunometabolic regulator of NLRP3 activation and IL-18 secretion in human macrophages..  Front Immunol,  13  (918551).  [PMID:36248901]
4. Estfanous S et al..  (2021)  Gasdermin D restricts Burkholderia cenocepacia infection in vitro and in vivo..  Sci Rep,  11  (855).  [PMID:33441602]
5. Shchepinova MM et al..  (2017)  MitoNeoD: A Mitochondria-Targeted Superoxide Probe..  Cell Chem Biol,  24  (10): (1285-1298.e12).  [PMID:28890317]
6. Mogilenko DA et al..  (2019)  Metabolic and Innate Immune Cues Merge into a Specific Inflammatory Response via the UPR..  Cell,  177  (5): (1201-1216.e19).  [PMID:31031005]
7. Booty LM et al..  (2019)  Selective Disruption of Mitochondrial Thiol Redox State in Cells and In\xa0Vivo..  Cell Chem Biol,  26  (3): (449-461.e8).  [PMID:30713096]
8. Bogacz M et al..  (2020)  The mitochondrial peroxiredoxin displays distinct roles in different developmental stages of African trypanosomes..  Redox Biol,  34  (101547).  [PMID:32388269]
9. Baker N et al..  (2022)  The mitochondrial protein OPA1 regulates the quiescent state of adult muscle stem cells..  Cell Stem Cell,  29  (9): (1315-1332.e9).  [PMID:35998642]

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