Grouped product items

SKU

Size

Availability

Price

Qty

D114215-100mg

100mg

Available within 4-8 weeks(?)

$113.90

Basic Description

Synonyms	mitotane\|53-19-0\|Mitotan\|Lysodren\|o,p'-DDD\|Chlodithane\|Chloditan\|Khlodithan\|Chlodithan\|1-(2-Chlorophenyl)-1-(4-chlorophenyl)-2,2-dichloroethane\|o,p'-TDE\|2,4'-Ddd\|Mitotano\|Opeprim\|Mitotanum\|2,4'-Dichlorodiphenyldichloroethane\|1-Chloro-2-(2,2-dichloro-1-(4-
Specifications & Purity	Moligand™, analytical standard
Biochemical and Physiological Mechanisms	Mitotane, or o,p'-DDD, is a derivative of DDT with antiproliferative properties. A study of the antiproliferative effects of Mitotane demonstrated particular efficacy against adrenocortical carcinoma.
Shipped In	Normal
Grade	analytical standard, Moligand™
Action Type	INHIBITOR
Mechanism of action	Cytochrome P450 11A1 inhibitor
Note	卖完停产，不再备货

Product Properties

ALogP	6.2

Associated Targets

CTNNBIP1 Tbio Beta-catenin-interacting protein 1 0 Activities

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CYP1A2 Tchem Cytochrome P450 1A2 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

DRD2 Tclin D(2) dopamine receptor 0 Activities

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DRD4 Tchem D(4) dopamine receptor 0 Activities

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CYP3A4 Tclin Cytochrome P450 3A4 0 Activities

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ERBB2 Tclin Receptor tyrosine-protein kinase erbB-2 0 Activities

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GABRA1 Tclin Gamma-aminobutyric acid receptor subunit alpha-1 0 Activities

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ELANE Tclin Neutrophil elastase 0 Activities

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EGFR Tclin Epidermal growth factor receptor 0 Activities

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AVPR1A Tclin Vasopressin V1a receptor 0 Activities

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HMGCR Tclin 3-hydroxy-3-methylglutaryl-coenzyme A reductase 0 Activities

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HIF1A Tchem Hypoxia-inducible factor 1-alpha 0 Activities

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HDAC6 Tclin Histone deacetylase 6 0 Activities

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HRH1 Tclin Histamine H1 receptor 0 Activities

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SLCO1B3 Tchem Solute carrier organic anion transporter family member 1B3 0 Activities

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SLC6A3 Tclin Sodium-dependent dopamine transporter 2 Activities

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SLC6A4 Tclin Sodium-dependent serotonin transporter 0 Activities

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SIGMAR1 Tclin Sigma non-opioid intracellular receptor 1 0 Activities

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PDE4D Tclin cAMP-specific 3',5'-cyclic phosphodiesterase 4D 0 Activities

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PTGS1 Tclin Prostaglandin G/H synthase 1 0 Activities

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CA2 Tclin Carbonic anhydrase 2 0 Activities

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DRD3 Tclin D(3) dopamine receptor 0 Activities

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CHRM3 Tclin Muscarinic acetylcholine receptor M3 0 Activities

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CHRM4 Tclin Muscarinic acetylcholine receptor M4 0 Activities

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ADRA2B Tclin Alpha-2B adrenergic receptor 0 Activities

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ADRA2C Tclin Alpha-2C adrenergic receptor 0 Activities

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HTR2A Tclin 5-hydroxytryptamine receptor 2A 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

ADORA2A Tclin Adenosine receptor A2a 0 Activities

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ACHE Tclin Acetylcholinesterase 0 Activities

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ADRA1A Tclin Alpha-1A adrenergic receptor 0 Activities

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AR Tclin Androgen receptor 0 Activities

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MAOA Tclin Amine oxidase [flavin-containing] A 0 Activities

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AKR1B1 Tclin Aldose reductase 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

ADORA1 Tclin Adenosine receptor A1 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

HTR1A Tclin 5-hydroxytryptamine receptor 1A 0 Activities

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ADORA3 Tchem Adenosine receptor A3 0 Activities

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HTR3A Tclin 5-hydroxytryptamine receptor 3A 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

HTR6 Tchem 5-hydroxytryptamine receptor 6 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

HTR2B Tclin 5-hydroxytryptamine receptor 2B 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

EDNRA Tclin Endothelin-1 receptor 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

KCNH2 Tclin Potassium voltage-gated channel subfamily H member 2 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

OPRD1 Tclin Delta-type opioid receptor 0 Activities

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OPRK1 Tclin Kappa-type opioid receptor 0 Activities

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OPRM1 Tclin Mu-type opioid receptor 0 Activities

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NOS2 Tchem Nitric oxide synthase, inducible 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

TACR1 Tclin Substance-P receptor 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

NOS1 Tchem Nitric oxide synthase, brain 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

IUPAC Name	1-chloro-2-[2,2-dichloro-1-(4-chlorophenyl)ethyl]benzene
INCHI	InChI=1S/C14H10Cl4/c15-10-7-5-9(6-8-10)13(14(17)18)11-3-1-2-4-12(11)16/h1-8,13-14H
InChi Key	JWBOIMRXGHLCPP-UHFFFAOYSA-N
Canonical SMILES	C1=CC=C(C(=C1)C(C2=CC=C(C=C2)Cl)C(Cl)Cl)Cl
Isomeric SMILES	C1=CC=C(C(=C1)C(C2=CC=C(C=C2)Cl)C(Cl)Cl)Cl
WGK Germany	3
RTECS	KH7880000
PubChem CID	4211
Molecular Weight	320.04
Beilstein	2056007

Database links

ChEMBL Ligand	CHEMBL1670
DrugBank Ligand	DB00648
PubChem CID	4211
CAS Registry No.	53-19-0
Wikipedia	Mitotane
DrugCentral Ligand	1820

Certificates

Certificate of Analysis(COA)

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To view the certificate results,please click on a Lot number.For Lot numbers from past orders,please use our order status section

1 results found

Lot Number	Certificate Type	Date	Item
H1915020	Certificate of Analysis	Mar 10, 2023	D114215

Chemical and Physical Properties

Solubility	Soluble in DMSO (≥ 64 mg/ml), ethanol (≥ 64 mg/ml), and water (< 1 mg/ml).,
Melt Point(°C)	77-78°C

Safety and Hazards(GHS)

Pictogram(s)	GHS08
Signal	Warning
Hazard Statements	H351:Suspected of causing cancer
Precautionary Statements	P280:Wear protective gloves/protective clothing/eye protection/face protection. P405:Store locked up. P501:Dispose of contents/container to ... P203:Obtain, read and follow all safety instructions before use. P318:if exposed or concerned, get medical advice.
WGK Germany	3
RTECS	KH7880000
Merck Index	6216

References

1. Libè R, Fratticci A, Bertherat J. (2007) Adrenocortical cancer: pathophysiology and clinical management.. Endocr Relat Cancer, 14 (1): (13-28). [PMID:17395972]
2. Lehmann TP, Wrzesiński T, Jagodziński PP. (2013) The effect of mitotane on viability, steroidogenesis and gene expression in NCI‑H295R adrenocortical cells.. Mol Med Rep, 7 (3): (893-900). [PMID:23254310]

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Mitotane - analytical standard, high purity , Cytochrome P450 11A1 inhibitor, CAS No.53-19-0, Cytochrome P450 11A1 inhibitor