Grouped product items

SKU

Size

Availability

Price

Qty

A174254-5mg

5mg

In stock

$129.90

A174254-10mg

10mg

In stock

$195.90

A174254-25mg

25mg

In stock

$325.90

A174254-50mg

50mg

In stock

$587.90

A174254-100mg

100mg

Available within 4-8 weeks(?)

$979.90

Basic Description

Synonyms	Mivebresib\|1445993-26-9\|ABBV-075\|ABBV075\|Mivebresib [INN]\|Mivebresib [USAN]\|N-(4-(2,4-difluorophenoxy)-3-(6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridin-4-yl)phenyl)ethanesulfonamide\|Mivebresib(ABBV-075\|VR86R11J7J\|MFCD30377200\|N-[4-(2,4-difluoropheno
Specifications & Purity	Moligand™, ≥98%
Storage Temp	Room temperature
Shipped In	Normal
Grade	Moligand™
Action Type	INHIBITOR
Mechanism of action	Inhibitor of bromodomain containing 4

Associated Targets

CYP3A4 Tclin Cytochrome P450 3A4 0 Activities

Discover Target: CYP3A4

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

EP300 Tchem Histone acetyltransferase p300 2 Activities

Discover Target: EP300

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

BRD4 Tchem Bromodomain-containing protein 4 16 Activities

Discover Target: BRD4

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CECR2 Tchem Cat eye syndrome critical region protein 2 0 Activities

Discover Target: CECR2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CDK2 Tchem Cyclin-dependent kinase 2 0 Activities

Discover Target: CDK2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CYP3A5 Tclin Cytochrome P450 3A5 0 Activities

Discover Target: CYP3A5

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

FGFR3 Tclin Fibroblast growth factor receptor 3 0 Activities

Discover Target: FGFR3

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

KAT2A Tchem Histone acetyltransferase KAT2A 0 Activities

Discover Target: KAT2A

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CSNK1D Tchem Casein kinase I isoform delta 0 Activities

Discover Target: CSNK1D

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

KAT2B Tchem Histone acetyltransferase KAT2B 0 Activities

Discover Target: KAT2B

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

TSPO Tchem Putative peripheral benzodiazepine receptor-related protein 0 Activities

Discover Target: TSPO

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

TSPO Tchem Translocator protein 1 Activities

Discover Target: TSPO

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

SMARCA4 Tchem Transcription activator BRG1 0 Activities

Discover Target: SMARCA4

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

TAF1L Tchem Transcription initiation factor TFIID subunit 1-like 0 Activities

Discover Target: TAF1L

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

TRIM24 Tchem Transcription intermediary factor 1-alpha 0 Activities

Discover Target: TRIM24

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

SMARCA2 Tchem Probable global transcription activator SNF2L2 0 Activities

Discover Target: SMARCA2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

PBRM1 Tchem Protein polybromo-1 0 Activities

Discover Target: PBRM1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

BRD9 Tchem Bromodomain-containing protein 9 0 Activities

Discover Target: BRD9

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

BRD7 Tchem Bromodomain-containing protein 7 0 Activities

Discover Target: BRD7

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

BRDT Tchem Bromodomain testis-specific protein 1 Activities

Discover Target: BRDT

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

BRPF3 Tchem Bromodomain and PHD finger-containing protein 3 0 Activities

Discover Target: BRPF3

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

BRD3 Tchem Bromodomain-containing protein 3 1 Activities

Discover Target: BRD3

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

BRPF1 Tchem Peregrin 0 Activities

Discover Target: BRPF1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

BRD2 Tchem Bromodomain-containing protein 2 1 Activities

Discover Target: BRD2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

BRD8 Tbio Bromodomain-containing protein 8 0 Activities

Discover Target: BRD8

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

BRWD1 Tbio Bromodomain and WD repeat-containing protein 1 0 Activities

Discover Target: BRWD1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

BAZ2A Tchem Bromodomain adjacent to zinc finger domain protein 2A 0 Activities

Discover Target: BAZ2A

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

BAZ2B Tchem Bromodomain adjacent to zinc finger domain protein 2B 0 Activities

Discover Target: BAZ2B

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

AURKA Tchem Aurora kinase A 0 Activities

Discover Target: AURKA

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

ADORA2B Tclin Adenosine receptor A2b 0 Activities

Discover Target: ADORA2B

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

ABL1 Tclin Tyrosine-protein kinase ABL1 0 Activities

Discover Target: ABL1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

ADORA1 Tclin Adenosine receptor A1 0 Activities

Discover Target: ADORA1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

TRIM33 Tchem E3 ubiquitin-protein ligase TRIM33 0 Activities

Discover Target: TRIM33

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

GSK3B Tclin Glycogen synthase kinase-3 beta 0 Activities

Discover Target: GSK3B

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

MAPK1 Tchem Mitogen-activated protein kinase 1 0 Activities

Discover Target: MAPK1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

IUPAC Name	N-[4-(2,4-difluorophenoxy)-3-(6-methyl-7-oxo-1H-pyrrolo[2,3-c]pyridin-4-yl)phenyl]ethanesulfonamide
INCHI	InChI=1S/C22H19F2N3O4S/c1-3-32(29,30)26-14-5-7-19(31-20-6-4-13(23)10-18(20)24)16(11-14)17-12-27(2)22(28)21-15(17)8-9-25-21/h4-12,25-26H,3H2,1-2H3
InChi Key	RDONXGFGWSSFMY-UHFFFAOYSA-N
Canonical SMILES	CCS(=O)(=O)NC1=CC(=C(C=C1)OC2=C(C=C(C=C2)F)F)C3=CN(C(=O)C4=C3C=CN4)C
Isomeric SMILES	CCS(=O)(=O)NC1=CC(=C(C=C1)OC2=C(C=C(C=C2)F)F)C3=CN(C(=O)C4=C3C=CN4)C
PubChem CID	71600087
Molecular Weight	459.47

Database links

PubChem CID	71600087
CAS Registry No.	1445993-26-9
RCSB PDB Ligand	8NG

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

References

1. McDaniel KF, Wang L, Soltwedel T, Fidanze SD, Hasvold LA, Liu D, Mantei RA, Pratt JK, Sheppard GS, Bui MH et al.. (2017) Discovery of N-(4-(2,4-Difluorophenoxy)-3-(6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridin-4-yl)phenyl)ethanesulfonamide (ABBV-075/Mivebresib), a Potent and Orally Available Bromodomain and Extraterminal Domain (BET) Family Bromodomain Inhibitor.. J Med Chem, 60 (20): (8369-8384). [PMID:28949521]

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Mivebresib - 98%, high purity , CAS No.1445993-26-9, Inhibitor of bromodomain containing 4

Basic Description

Associated Targets

CYP3A4 Tclin Cytochrome P450 3A4 0 Activities

EP300 Tchem Histone acetyltransferase p300 2 Activities

BRD4 Tchem Bromodomain-containing protein 4 16 Activities

CECR2 Tchem Cat eye syndrome critical region protein 2 0 Activities

CDK2 Tchem Cyclin-dependent kinase 2 0 Activities

CYP3A5 Tclin Cytochrome P450 3A5 0 Activities

FGFR3 Tclin Fibroblast growth factor receptor 3 0 Activities

KAT2A Tchem Histone acetyltransferase KAT2A 0 Activities

CSNK1D Tchem Casein kinase I isoform delta 0 Activities

KAT2B Tchem Histone acetyltransferase KAT2B 0 Activities

TSPO Tchem Putative peripheral benzodiazepine receptor-related protein 0 Activities

TSPO Tchem Translocator protein 1 Activities

SMARCA4 Tchem Transcription activator BRG1 0 Activities

TAF1L Tchem Transcription initiation factor TFIID subunit 1-like 0 Activities

TRIM24 Tchem Transcription intermediary factor 1-alpha 0 Activities

SMARCA2 Tchem Probable global transcription activator SNF2L2 0 Activities

PBRM1 Tchem Protein polybromo-1 0 Activities

BRD9 Tchem Bromodomain-containing protein 9 0 Activities

BRD7 Tchem Bromodomain-containing protein 7 0 Activities

BRDT Tchem Bromodomain testis-specific protein 1 Activities

BRPF3 Tchem Bromodomain and PHD finger-containing protein 3 0 Activities

BRD3 Tchem Bromodomain-containing protein 3 1 Activities

BRPF1 Tchem Peregrin 0 Activities

BRD2 Tchem Bromodomain-containing protein 2 1 Activities

BRD8 Tbio Bromodomain-containing protein 8 0 Activities

BRWD1 Tbio Bromodomain and WD repeat-containing protein 1 0 Activities

BAZ2A Tchem Bromodomain adjacent to zinc finger domain protein 2A 0 Activities

BAZ2B Tchem Bromodomain adjacent to zinc finger domain protein 2B 0 Activities

AURKA Tchem Aurora kinase A 0 Activities

ADORA2B Tclin Adenosine receptor A2b 0 Activities

ABL1 Tclin Tyrosine-protein kinase ABL1 0 Activities

ADORA1 Tclin Adenosine receptor A1 0 Activities

TRIM33 Tchem E3 ubiquitin-protein ligase TRIM33 0 Activities

GSK3B Tclin Glycogen synthase kinase-3 beta 0 Activities

MAPK1 Tchem Mitogen-activated protein kinase 1 0 Activities

Names and Identifiers

Database links

Certificates

Certificate of Analysis(COA)

Related Documents

References

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