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MK-5108 (VX-689) - ≥98%, high purity , Serine/threonine-protein kinase Aurora-A inhibitor, CAS No.1010085-13-8, Serine/threonine-protein kinase Aurora-A inhibitor

Moligand™
≥98%

CAS#: 1010085-13-8
Formula: C₂₂H₂₁ClFN₃O₃S
Molecular Weight: 461.94
PubChem CID: 24748204
PubChem SID: 488200675

Item Number

M127979

Grouped product items
SKU	Size	Availability	Price
M127979-5mg	5mg	In stock	$98.90
M127979-10mg	10mg	In stock	$167.90
M127979-25mg	25mg	In stock	$378.90
M127979-50mg	50mg	In stock	$444.90
M127979-100mg	100mg	In stock	$741.90
M127979-200mg	200mg	In stock	$1,335.90

View related series

aurora kinase A Inhibitor aurora kinase B Inhibitor aurora kinase C Inhibitor

Basic Description

Synonyms	MK-5108\|1010085-13-8\|VX-689\|MK 5108\|MK5108\|MK-5108 (VX-689)\|VX689\|VX 689\|4-(3-chloro-2-fluorophenoxy)-1-[[6-(1,3-thiazol-2-ylamino)pyridin-2-yl]methyl]cyclohexane-1-carboxylic acid\|(1r,4r)-4-(3-chloro-2-fluorophenoxy)-1-((6-(thiazol-2-ylamino)pyridin-2-yl
Specifications & Purity	≥98%
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Grade	Moligand™
Action Type	INHIBITOR
Mechanism of action	Serine/threonine-protein kinase Aurora-A inhibitor

Associated Targets

IRAK3 Tchem Interleukin-1 receptor-associated kinase 3 1 Activities

Discover Target: IRAK3

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

TNK1 Tchem Non-receptor tyrosine-protein kinase TNK1 1 Activities

Discover Target: TNK1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

BCR Tclin Breakpoint cluster region protein 1 Activities

Discover Target: BCR

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

AURKA Tchem Aurora kinase A 2 Activities

Discover Target: AURKA

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

AURKB Tchem Aurora kinase B 1 Activities

Discover Target: AURKB

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

AURKC Tchem Aurora kinase C 1 Activities

Discover Target: AURKC

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

JAK2 Tclin Tyrosine-protein kinase JAK2 1 Activities

Discover Target: JAK2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

Pubchem Sid	488200675
Pubchem Sid Url	https://pubchem.ncbi.nlm.nih.gov/substance/488200675
IUPAC Name	4-(3-chloro-2-fluorophenoxy)-1-[[6-(1,3-thiazol-2-ylamino)pyridin-2-yl]methyl]cyclohexane-1-carboxylic acid
INCHI	InChI=1S/C22H21ClFN3O3S/c23-16-4-2-5-17(19(16)24)30-15-7-9-22(10-8-15,20(28)29)13-14-3-1-6-18(26-14)27-21-25-11-12-31-21/h1-6,11-12,15H,7-10,13H2,(H,28,29)(H,25,26,27)
InChi Key	LCVIRAZGMYMNNT-UHFFFAOYSA-N
Canonical SMILES	C1CC(CCC1OC2=C(C(=CC=C2)Cl)F)(CC3=NC(=CC=C3)NC4=NC=CS4)C(=O)O
Isomeric SMILES	C1CC(CCC1OC2=C(C(=CC=C2)Cl)F)(CC3=NC(=CC=C3)NC4=NC=CS4)C(=O)O
PubChem CID	24748204
Molecular Weight	461.94

PubChem CID

CAS Registry No.

ChEMBL Ligand

PubChem SID

Certificates

Certificate of Analysis(COA)

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24 results found

Lot Number	Certificate Type	Date	Item
F2325084	Certificate of Analysis	May 29, 2023	M127979
F2325098	Certificate of Analysis	May 29, 2023	M127979
F2325096	Certificate of Analysis	May 29, 2023	M127979
F2325094	Certificate of Analysis	May 29, 2023	M127979
F2325093	Certificate of Analysis	May 29, 2023	M127979
F2325092	Certificate of Analysis	May 29, 2023	M127979
F2325090	Certificate of Analysis	May 29, 2023	M127979
F2325089	Certificate of Analysis	May 29, 2023	M127979
F2325088	Certificate of Analysis	May 29, 2023	M127979
F2325087	Certificate of Analysis	May 29, 2023	M127979
F2325086	Certificate of Analysis	May 29, 2023	M127979
F2325085	Certificate of Analysis	May 29, 2023	M127979
D2321866	Certificate of Analysis	Mar 20, 2023	M127979
D2321986	Certificate of Analysis	Mar 20, 2023	M127979
D2321979	Certificate of Analysis	Mar 20, 2023	M127979
D2321973	Certificate of Analysis	Mar 20, 2023	M127979
D2321969	Certificate of Analysis	Mar 20, 2023	M127979
D2321964	Certificate of Analysis	Mar 20, 2023	M127979
D2321963	Certificate of Analysis	Mar 20, 2023	M127979
D2321944	Certificate of Analysis	Mar 20, 2023	M127979
D2321890	Certificate of Analysis	Mar 20, 2023	M127979
D2321889	Certificate of Analysis	Mar 20, 2023	M127979
D2321888	Certificate of Analysis	Mar 20, 2023	M127979
D2321878	Certificate of Analysis	Mar 20, 2023	M127979

References

1. Shimomura T, Hasako S, Nakatsuru Y, Mita T, Ichikawa K, Kodera T, Sakai T, Nambu T, Miyamoto M, Takahashi I et al.. (2010) MK-5108, a highly selective Aurora-A kinase inhibitor, shows antitumor activity alone and in combination with docetaxel.. Mol Cancer Ther, 9 (1): (157-66). [PMID:20053775]
2. Willemsen-Seegers N, Uitdehaag JCM, Prinsen MBW, de Vetter JRF, de Man J, Sawa M, Kawase Y, Buijsman RC, Zaman GJR. (2017) Compound Selectivity and Target Residence Time of Kinase Inhibitors Studied with Surface Plasmon Resonance.. J Mol Biol, 429 (4): (574-586). [PMID:28043854]

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