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Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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M126295-1mg | 1mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $139.90 | |
M126295-5mg | 5mg | In stock | $296.90 | |
M126295-10mg | 10mg | In stock | $450.90 | |
M126295-25mg | 25mg | In stock | $1,014.90 | |
M126295-50mg | 50mg | In stock | $1,068.90 | |
M126295-100mg | 100mg | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $1,662.90 |
Synonyms | MK-6892|917910-45-3|PH9ZB6IRW0|MK 6892|CHEMBL1086657|1-Cyclohexene-1-carboxylic acid, 2-((3-(3-(5-hydroxy-2-pyridinyl)-1,2,4-oxadiazol-5-yl)-2,2-dimethyl-1-oxopropyl)amino)-|2-[[3-[3-(5-Hydroxypyridin-2-yl)-1,2,4-oxadiazol-5-yl]-2,2-dimethylpropanoyl]amin |
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Specifications & Purity | Moligand™, ≥98% |
Biochemical and Physiological Mechanisms | Description: |
Storage Temp | Store at -20°C |
Shipped In | Ice chest + Ice pads |
Grade | Moligand™ |
Action Type | AGONIST |
Mechanism of action | Agonist of HCA 2 receptor |
Product Description | application: Description: IC50 Value: 4.0 nM (Ki for Human GPR109A) MK-6892 is a highly potential GPR109A agonists. in vitro: . Despite the increased serum shift of these compounds, the representative 1e was highly potent. Furthermore, these compounds had no activity on GPR109B and GPR81, the two most closely related GPCRs with ?96% and 50% sequence identity to GPR109A,respectively . in vivo: NA or MK-6892 was orally administered to WT or NA receptor null mice on the same C57Bl/6 genetic background. After 15 min of 100 mpk dosing of NA or MK-6892 to fed WT or NA receptor null mice, the blood levels of MK-6892 at 15 min were 229 μM (?950-fold greater than the in vitro EC50 determined in mouse NA receptor GTPγS assay, which is 240 nM) in WT mice and 148 μM (?620-fold greater than the in vitro EC50) in NA receptor null mice . Clinical trial: N/A |
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IUPAC Name | 2-[[3-[3-(5-hydroxypyridin-2-yl)-1,2,4-oxadiazol-5-yl]-2,2-dimethylpropanoyl]amino]cyclohexene-1-carboxylic acid |
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INCHI | InChI=1S/C19H22N4O5/c1-19(2,18(27)21-13-6-4-3-5-12(13)17(25)26)9-15-22-16(23-28-15)14-8-7-11(24)10-20-14/h7-8,10,24H,3-6,9H2,1-2H3,(H,21,27)(H,25,26) |
InChi Key | CJHXBFSJXDUJHP-UHFFFAOYSA-N |
Canonical SMILES | CC(C)(CC1=NC(=NO1)C2=NC=C(C=C2)O)C(=O)NC3=C(CCCC3)C(=O)O |
Isomeric SMILES | CC(C)(CC1=NC(=NO1)C2=NC=C(C=C2)O)C(=O)NC3=C(CCCC3)C(=O)O |
PubChem CID | 135416394 |
Molecular Weight | 386.4 |
CAS Registry No. | 917910-45-3 |
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ChEMBL Ligand | CHEMBL1086657 |
PubChem CID | 73755154 |
GPCRdb Ligand | MK 6892 |
RCSB PDB Ligand | FI7 |
Enter Lot Number to search for COA:
To view the certificate results,please click on a Lot number.For Lot numbers from past orders,please use our order status section
Lot Number | Certificate Type | Date | Item |
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L2125120 | Certificate of Analysis | Oct 09, 2023 | M126295 |
L2125121 | Certificate of Analysis | Oct 09, 2023 | M126295 |
L2125122 | Certificate of Analysis | Oct 09, 2023 | M126295 |
L2125123 | Certificate of Analysis | Oct 09, 2023 | M126295 |
L2125124 | Certificate of Analysis | Oct 09, 2023 | M126295 |
Solubility | 25°C: DMSO |
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