ML-211 is a carbamate-based dual inhibitor of acyl-protein thioesterase 1 (APT1)/lysophospholipase 1 (LYPLA1) ( IC 50 =17 nM) and LYPLA2 ( IC 50 =30 nM). ML-211 also inhibits theserine hydrolase ABHD11 with an IC 50 value of 10 nM but is ≥ 50-fold selective for LYPLA in a panel of 20 additional serine hydrolases.
