The store will not work correctly when cookies are disabled.
JavaScript seems to be disabled in your browser. For the best experience on our site, be sure to turn on Javascript in your browser.
ML 337 - ≥98%(HPLC), high purity , CAS No.1443118-44-2, Allosteric modulator of mGlu 3 receptor
Selective negative allosteric modulator of mGlu3receptors
Basic Description Synonyms [2-Fluoro-4-[2-(4-methoxyphenyl)ethynyl]phenyl][(3R)-3-hydroxy-1-piperidinyl]methanone;ML337;(R)-(2-fluoro-4-((4-methoxyphenyl)ethynyl)phenyl)(3-hydroxypiperidin-1-yl)methanone; Specifications & Purity Moligand™, ≥98%(HPLC) Biochemical and Physiological Mechanisms Selective negative allosteric modulator of mGlu3(IC50= 593 nM). Displays no activity at mGlu1, mGlu2or mGlu4-8at concentrations up to 30μM. Brain penetrant. Storage Temp Store at -20°C Shipped In Ice chest + Ice pads Grade Moligand™ Action Type ALLOSTERIC MODULATOR Mechanism of action Allosteric modulator of mGlu 3 receptor
Names and Identifiers IUPAC Name [2-fluoro-4-[2-(4-methoxyphenyl)ethynyl]phenyl]-[(3R)-3-hydroxypiperidin-1-yl]methanone INCHI InChI=1S/C21H20FNO3/c1-26-18-9-6-15(7-10-18)4-5-16-8-11-19(20(22)13-16)21(25)23-12-2-3-17(24)14-23/h6-11,13,17,24H,2-3,12,14H2,1H3/t17-/m1/s1 InChi Key QBCRLDPMQHPGIM-QGZVFWFLSA-N Canonical SMILES COC1=CC=C(C=C1)C#CC2=CC(=C(C=C2)C(=O)N3CCCC(C3)O)F Isomeric SMILES COC1=CC=C(C=C1)C#CC2=CC(=C(C=C2)C(=O)N3CCC[C@H](C3)O)F PubChem CID 60204017 Molecular Weight 353.39
Chemical and Physical Properties Solubility Solvent:DMSO, Max Conc. mg/mL: 35.34, Max Conc. mM: 100; Solvent:ethanol, Max Conc. mg/mL: 7.07, Max Conc. mM: 20
References 1. Wenthur CJ, Morrison R, Felts AS, Smith KA, Engers JL, Byers FW, Daniels JS, Emmitte KA, Conn PJ, Lindsley CW. (2013) Discovery of (R)-(2-fluoro-4-((-4-methoxyphenyl)ethynyl)phenyl) (3-hydroxypiperidin-1-yl)methanone (ML337), an mGlu3 selective and CNS penetrant negative allosteric modulator (NAM).. J Med Chem, 56 (12): (5208-12). [PMID:23718281 ]
Solution Calculators Molarity Calculator Determine the necessary mass, volume, or concentration for preparing a solution.
Dilution Calculator Determine the dilution needed to prepare a stock solution.
Reconstitution Calculator