Skip to the beginning of the images gallery

ML 347 - ≥98%(HPLC), high purity , CAS No.1062368-49-3, Inhibitor of activin A receptor type 1;Inhibitor of activin A receptor type IL;Inhibitor of bone morphogenetic protein receptor type IA

Moligand™
≥98%(HPLC)

CAS#: 1062368-49-3
Formula: C₂₂H₁₆N₄O
Molecular Weight: 352.39
PubChem CID: 44577753

Item Number

M287398

Grouped product items
SKU	Size	Availability	Price
M287398-5mg	5mg	In stock	$64.90
M287398-10mg	10mg	In stock	$97.90
M287398-50mg	50mg	In stock	$380.90
M287398-100mg	100mg	In stock	$652.90

Potent and selective ALK1 and ALK2 inhibitor

View related series

activin A receptor type 1 Inhibitor activin A receptor type IL Inhibitor bone morphogenetic protein receptor type IA Inhibitor

Basic Description

Synonyms	LDN 193719, 1lWY, VU0469381;5-[6-(4-Methoxyphenyl)pyrazolo[1,5-a]pyrimidin-3-yl]quinoline
Specifications & Purity	Moligand™, ≥98%(HPLC)
Biochemical and Physiological Mechanisms	Potent and selective ALK2 and ALK1 inhibitor (IC50values are 32 and 46 nM, respectively); displays >200 fold selectivity over ALK3 and ALK6 and >400 fold selectivity over VEGF2. Exhibits no activity at ALK4, ALK5 or in a panel of related kinases. Inhibits
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Grade	Moligand™
Action Type	INHIBITOR
Mechanism of action	Inhibitor of activin A receptor type 1;Inhibitor of activin A receptor type IL;Inhibitor of bone morphogenetic protein receptor type IA

Associated Targets

HDAC6 Tclin Histone deacetylase 6 0 Activities

Discover Target: HDAC6

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

TGFBR1 Tchem TGF-beta receptor type-1 0 Activities

Discover Target: TGFBR1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

TGFBR2 Tchem TGF-beta receptor type-2 0 Activities

Discover Target: TGFBR2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

BMPR2 Tchem Bone morphogenetic protein receptor type-2 0 Activities

Discover Target: BMPR2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

BMPR1B Tchem Bone morphogenetic protein receptor type-1B 0 Activities

Discover Target: BMPR1B

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

BMPR1A Tchem Bone morphogenetic protein receptor type-1A 1 Activities

Discover Target: BMPR1A

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

BMP4 Tchem Bone morphogenetic protein 4 0 Activities

Discover Target: BMP4

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

KDR Tclin Vascular endothelial growth factor receptor 2 0 Activities

Discover Target: KDR

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

ACVR1 Tchem Activin receptor type-1 1 Activities

Discover Target: ACVR1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

PRKAB1 Tchem 5'-AMP-activated protein kinase subunit beta-1 0 Activities

Discover Target: PRKAB1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

ACVRL1 Tchem Serine/threonine-protein kinase receptor R3 1 Activities

Discover Target: ACVRL1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

ACVR1B Tchem Activin receptor type-1B 0 Activities

Discover Target: ACVR1B

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

IUPAC Name	5-[6-(4-methoxyphenyl)pyrazolo[1,5-a]pyrimidin-3-yl]quinoline
INCHI	InChI=1S/C22H16N4O/c1-27-17-9-7-15(8-10-17)16-12-24-22-20(13-25-26(22)14-16)18-4-2-6-21-19(18)5-3-11-23-21/h2-14H,1H3
InChi Key	FVRYPYDPKSZGNS-UHFFFAOYSA-N
Canonical SMILES	COC1=CC=C(C=C1)C2=CN3C(=C(C=N3)C4=C5C=CC=NC5=CC=C4)N=C2
Isomeric SMILES	COC1=CC=C(C=C1)C2=CN3C(=C(C=N3)C4=C5C=CC=NC5=CC=C4)N=C2
PubChem CID	44577753
Molecular Weight	352.39

ChEMBL Ligand

CAS Registry No.

BindingDB Ligand

PubChem CID

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

To view the certificate results,please click on a Lot number.For Lot numbers from past orders,please use our order status section

4 results found

Lot Number	Certificate Type	Date	Item
F2225455	Certificate of Analysis	May 31, 2022	M287398
F2225456	Certificate of Analysis	May 31, 2022	M287398
F2225459	Certificate of Analysis	May 31, 2022	M287398
F2225460	Certificate of Analysis	May 31, 2022	M287398

References

1. Engers DW, Frist AY, Lindsley CW, Hong CC, Hopkins CR. (2013) Synthesis and structure-activity relationships of a novel and selective bone morphogenetic protein receptor (BMP) inhibitor derived from the pyrazolo[1.5-a]pyrimidine scaffold of dorsomorphin: the discovery of ML347 as an ALK2 versus ALK3 selective MLPCN probe.. Bioorg Med Chem Lett, 23 (11): (3248-52). [PMID:23639540]

Solution Calculators

Molarity Calculator

Determine the necessary mass, volume, or concentration for preparing a solution.

Dilution Calculator

Determine the dilution needed to prepare a stock solution.