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ML213 - 98% (HPLC), high purity , CAS No.489402-47-3, Activator of K v7.4

Moligand™
≥98%(HPLC)

CAS#: 489402-47-3
Formula: C₁₇H₂₃NO
Molecular Weight: 257.37
PubChem CID: 3111211

Item Number

M170566

Grouped product items
SKU	Size	Availability	Price
M170566-5mg	5mg	In stock	$64.90
M170566-25mg	25mg	In stock	$220.90
M170566-100mg	100mg	In stock	$639.90

KV7.2 and KV7.4 channel opener

View related series

Kv7.4 Activator

Basic Description

Synonyms	ML213\|489402-47-3\|N-mesitylbicyclo[2.2.1]heptane-2-carboxamide\|ML 213\|ML-213\|N-(2,4,6-trimethylphenyl)bicyclo[2.2.1]heptane-2-carboxamide\|CHEMBL1703636\|CID-3111211\|N-(2,4,6-trimethylphenyl)bicyclo[2.2.1]heptane-6-carboxamide\|Bicyclo[2.2.1]heptane-2-carbox
Specifications & Purity	Moligand™, ≥98%(HPLC)
Biochemical and Physiological Mechanisms	Selective KV7.2 (KCNQ2) and KV7.4 (KCNQ4) channel opener (EC50values are 230 and 510 nM for KV7.2 and KV7.4 respectively). Displays > 80-fold selectivity against KV7.1, KV7.3 and KV7.5 in a thallium-based fluorescence assay. Hyperpolarizes resting membran
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Grade	Moligand™
Action Type	ACTIVATOR
Mechanism of action	Activator of K v7.4

Associated Targets

HDAC6 Tclin Histone deacetylase 6 0 Activities

Discover Target: HDAC6

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

KCNQ4 Tclin Potassium voltage-gated channel subfamily KQT member 4 2 Activities

Discover Target: KCNQ4

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

KCNQ5 Tclin Potassium voltage-gated channel subfamily KQT member 5 0 Activities

Discover Target: KCNQ5

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

TDP1 Tchem Tyrosyl-DNA phosphodiesterase 1 0 Activities

Discover Target: TDP1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

ATAD5 Tbio ATPase family AAA domain-containing protein 5 0 Activities

Discover Target: ATAD5

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

KCNQ2 Tclin Potassium voltage-gated channel subfamily KQT member 2 0 Activities

Discover Target: KCNQ2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

IUPAC Name	N-(2,4,6-trimethylphenyl)bicyclo[2.2.1]heptane-2-carboxamide
INCHI	InChI=1S/C17H23NO/c1-10-6-11(2)16(12(3)7-10)18-17(19)15-9-13-4-5-14(15)8-13/h6-7,13-15H,4-5,8-9H2,1-3H3,(H,18,19)
InChi Key	SIQGKPGBLYKQBB-UHFFFAOYSA-N
Canonical SMILES	CC1=CC(=C(C(=C1)C)NC(=O)C2CC3CCC2C3)C
Isomeric SMILES	CC1=CC(=C(C(=C1)C)NC(=O)C2CC3CCC2C3)C
WGK Germany	3
PubChem CID	3111211
Molecular Weight	257.37

PubChem CID

3111211

CAS Registry No.

489402-47-3

ChEMBL Ligand

CHEMBL1703636

Certificates

Certificate of Analysis(COA)

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3 results found

Lot Number	Certificate Type	Date	Item
G2206395	Certificate of Analysis	May 26, 2022	M170566
G2206432	Certificate of Analysis	May 26, 2022	M170566
G2206461	Certificate of Analysis	May 26, 2022	M170566

Safety and Hazards(GHS)

Pictogram(s)	GHS07
Signal	Warning
Hazard Statements	H315:Causes skin irritation H319:Causes serious eye irritation H335:May cause respiratory irritation H413:May cause long lasting harmful effects to aquatic life
Precautionary Statements	P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P273:Avoid release to the environment. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P271:Use only outdoors or in a well-ventilated area. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P362+P364:Take off contaminated clothing and wash it before reuse. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P337+P317:If eye irritation persists: Get medical help. P332+P317:If skin irritation occurs: Get medical help. P319:Get medical help if you feel unwell.
WGK Germany	3

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