Discover ML297 (VU0456810) by Aladdin Scientific in ≥99% for only $85.90. Available - in Ligands at Aladdin Scientific. Potent, selective GIRK activator Tags: .
Basic Description
Specifications & Purity
≥99%
Storage Temp
Store at 2-8°C
Shipped In
Wet ice
Product Description
Store at +4°C. The product can be stored for up to 12 months.
Certificates
Certificate of Analysis(COA)
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Chemical and Physical Properties
Solubility
Soluble in DMSO to 100 mM and in ethanol to 50 mM (with warming)
1.Nimitvilai S et al.. (2018) Effects of monoamines on the intrinsic excitability of lateral orbitofrontal cortex neurons in alcohol-dependent and non-dependent female mice.. Neuropharmacology, 137 (1-12). [PMID:29689260]
2.Huang Y et al.. (2018) GIRK1-mediated inwardly rectifying potassium current suppresses the epileptiform burst activities and the potential antiepileptic effect of ML297.. Biomed Pharmacother, 101 (362-370). [PMID:29499411]
3.Djebari S et al.. (2021) G-Protein-Gated Inwardly Rectifying Potassium (Kir3/GIRK) Channels Govern Synaptic Plasticity That Supports Hippocampal-Dependent Cognitive Functions in Male Mice.. J Neurosci, 41 (33):(7086-7102). [PMID:34261700]
4.Sánchez-Rodríguez I et al.. (2020) Hippocampal long-term synaptic depression and memory deficits induced in early amyloidopathy are prevented by enhancing G-protein-gated inwardly rectifying potassium channel activity.. J Neurochem, 153 (3):(362-376). [PMID:31875959]
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